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FDXR encodes a mitochondrial flavoprotein that initiates electron transport for cytochromes P450 receiving electrons from NADPH.
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S. pombe is either very robust to mitochondrial reactive oxygen species (ROS (show ROS1 Antibodies)) production or does not undergo apoptotic cell death in response to mitochondrial ROS (show ROS1 Antibodies) at all.
Using surface plasmon resonance, physiologically relevant concentrations of isatin (25-100 muM) were found to increase affinity of interactions between human recombinant ferrochelatase (FECH (show FECH Antibodies)) and NADPH (show NQO1 Antibodies)-dependent adrenodoxin reductase (ADR).
Mutation in FDXR gene is associated with Sensorial Neuropathies.
NOS-3 (show NANOS3 Antibodies) overexpression resulted in an increased sensitivity to anti-Fas (show FAS Antibodies) induced cell death, independently of AR expression and CatD (show CTSD Antibodies) activity.
These results indicated that abundant FDXR expression in these steroidogenic cells was maintained through SF-1 (show NR5A1 Antibodies) binding to the intronic enhancer of the FDXR gene
results suggest that both FDX1 (show FDX1 Antibodies) and FDX2 and their likely reductase partner, FDXR, contribute to iron-sulfur cluster biogenesis
comparison of catalytic properties between conditions of limiting and saturating adrenodoxin reductase [cytochrome P450scc (show CYP11A1 Antibodies)]
The ferredoxin reductase gene is regulated by the p53 (show TP53 Antibodies) family and sensitizes cells to oxidative stress-induced (show SQSTM1 Antibodies) apoptosis
ADXR rate of hydroxylation was linear with incubation time.
This gene encodes a mitochondrial flavoprotein that initiates electron transport for cytochromes P450 receiving electrons from NADPH. Multiple alternatively spliced transcript variants have been found for this gene.
NADPH:adrenodoxin oxidoreductase, mitochondrial
, adrenodoxin reductase
, ferredoxin--NADP(+) reductase
, ferredoxin reductase
, ferredoxin--NADP reductase
, adrenodoxin-NADP(+) reductase
, ferredoxin reductase L homeolog