Fibrillin 3 (FBN3) ELISA Kits

Xenopus laevis Fibrillin 3 (FBN3) interaction partners

1. suggested that one role for XF is to serve as a mechanical element in the embryo prior to bone deposition

2. native Xenopus fibrillin is essential for the process of directed convergent extension in presumptive notochord at gastrulation

Human Fibrillin 3 (FBN3) interaction partners

1. an association study showed a potential association of the D19S884 marker with PCOS in Chinese Han women and the meta-analysis identified that the A8 allele may increase susceptibility to PCOS

2. The FBN3 risk allele may be associated with changes in basal glucose homeostasis in PCOS.

3. Data show that TGF-beta pathways operate during ovarian fetal development, and fibrillin 3 is highly expressed at a critical stage early in developing human and bovine fetal ovaries.

4. fibrillin-3, compared to the other fibrillins, fulfills both overlapping and distinct functions in human development

5. A variant in the fibrillin-3 gene is associated with TGF-beta and inhibin B levels in women with polycystic ovary syndrome.

6. Loss of fibrillin-3 during folliculogenesis may be an important factor in polycystic ovary syndrome pathogenesis.

7. Single nucleotide polymorphisms in FBN3 occur and may be a candidate gene for polycystic ovary syndrome.

8. Data show that fibrillin 3 appears to have little involvement in PCOS but cannot rule out that other markers in the region of chromosome 19p13.2 are associated with PCOS or that FBN3 expression occurs in other organs that may influence the PCOS phenotype.

9. fibrillin-3 gene showed the strongest evidence for association with Polycystic ovary syndrome

Cow (Bovine) Fibrillin 3 (FBN3) interaction partners

1. Data show that TGF-beta pathways operate during ovarian fetal development, and fibrillin 3 is highly expressed at a critical stage early in developing human and bovine fetal ovaries.

2. This is the first study to investigate the expression and localization of fibrillin proteins and latent TGF-beta binding proteins affecting TGFbeta bioavailability in the ovary.