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The protein encoded by FGB is the beta component of fibrinogen, a blood-borne glycoprotein comprised of three pairs of nonidentical polypeptide chains.
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Binding of human fibrinogen to MRP enhances Streptococcus suis survival in host blood in a alphaXbeta2 integrin-dependent manner.
FGB mutations leading to congenital hypofibrinogenaemia
Fibrinogen Bbeta448Lys variant is associated with thrombotic fibrin clots in type 2 diabetic patients independently of traditional risk factors.
There was underexpression of the majority of genes after sunitinib treatment. The lower expression levels of IGFBP1 (show IGFBPI ELISA Kits), CCL20 (show CCL20 ELISA Kits), CXCL6 and FGB were confirmed by qRT-PCR in all cases. The downregulation of gene expression leads us to search for methylation as a mechanism of action of the tyrosine kinase (show TXK ELISA Kits) inhibitors
elevated levels of plasma homocysteine /homocysteine thiolactone contribute to AD pathology via the Abeta (show APP ELISA Kits)-fibrin(ogen) interaction
Heterozygous FV Leiden, homozygous PAI-1 4G/4G, heterozygous MTHFR C677T, homozygous MTHFR A1298C, as much as the combined thrombophilic genotypes MTHFR 677T + ACE Iota/D, MTHFR 677T/1298C + ACE D/D, ACE I/D + b-fibrinogen -455 G/A, FV HR2 + b-fibrinogen -455 G/A showed a correlation as risk factors for Recurrent pregnancy loss.
procoagulant changes in fibrin metastructure appear to result from excessive carbonylation of fibrinogen, which may compensate for a decrease in fibrinogen level in patients with cirrhosis
Prognostic impact of plasma fibrinogen levels in patients with esophageal squamous cell carcinoma
Data indicate that repeated measurement after five hours showed a statistical significant difference for the fractional synthesis rate of fibrinogen but not for albumin (show ALB ELISA Kits).
a tight cluster of alternating multiple splicing regulatory elements and U1 snRNA binding sites controls cryptic splice donor usage throughout the human fibrinogen Bbeta-chain gene (FGB) exon 7
Data suggest that the interaction between Abeta and fibrinogen may be an important contributor to the vascular abnormalities found in Alzheimer's disease.
beta(3) integrin, thrombin (show F2 ELISA Kits), and Ca(2 (show CA2 ELISA Kits)+) play critical roles in platelet aggregation without fibrinogen or VWF (show VWF ELISA Kits)
Data suggest the potential compensatory role of fibrinogen in restoring coagulation function in vivo after hemorrhagic shock.
The protein encoded by this gene is the beta component of fibrinogen, a blood-borne glycoprotein comprised of three pairs of nonidentical polypeptide chains. Following vascular injury, fibrinogen is cleaved by thrombin to form fibrin which is the most abundant component of blood clots. In addition, various cleavage products of fibrinogen and fibrin regulate cell adhesion and spreading, display vasoconstrictor and chemotactic activities, and are mitogens for several cell types. Mutations in this gene lead to several disorders, including afibrinogenemia, dysfibrinogenemia, hypodysfibrinogenemia and thrombotic tendency.
fibrinogen, B beta polypeptide
, fibrinogen beta chain
, B fibrinopeptide
, fibrinogen, beta chain
, B beta polypeptide
, fibrinogen, beta polypeptide
, liver regeneration-related protein LRRG036/LRRG043/LRRG189
, fibrinogen beta chain-like
, fibrinogen B-beta subunit