Fibrinogen beta Chain (FGB) ELISA Kits

Human Fibrinogen beta Chain (FGB) interaction partners

1. Fibrinogen FGA, FGB and FGG genes were sequenced in 17 patients by next-generation sequencing. Variants leading to fibrinogen deficiency were found in all patients. Eight novel variants were described.

2. FGB polymorphisms -455G/A and -148C/T are associated with coronary artery disease risk and fibrinogen plasma level.

3. Chromatin interactions are important for the coordinated regulation of the human fibrinogen genes. Deletion of a CTCF site at one edge of the cluster altered chromatin interactions, reduced steady-state expression of FGB mRNA, and led to a halving of secreted fibrinogen.

4. FGB -455G>A polymorphism may be a protective factor for Venous Thromboembolism among the Caucasian population.

5. Multivariate analysis adjusted for potential confounders and demonstrated that FGB 455 G/A was independently associated with increased risk of cardioembolic stroke in atrial fibrillation patients. Plasma fibrinogen levels were significantly higher in patients with the A allele compared with patients with genotype of GG.

6. The data of this study support the notion that fibrinogen is a key player in the early pathogenesis, as well as sustained inflammation, of inflammatory demyelinating lesions

7. Meta-analysis/Review: beta-fibrinogen polymosphisms are associated with the risk of ischemic stroke.

8. All the exons and exon-intron boundaries of fibrinogen genes (FGA, FGB and FGG) were analysed by direct DNA sequencing

9. High fibrinogen expression is associated with esophageal carcinoma.

10. Compared with the patients with TT genotypes of fibrinogen beta, expressions of fibrinogen, IL-6 and CRP were significantly higher in the patients with the CC and CT genotypes.

11. Two novel fibrinogen Bbeta chain mutations in two Slovak families with hypofibrinogenemia/afibrinogenemia have been described.

12. Data defined the mutational burden of the fibrinogen FGA, FGB, and FGG genes, and estimated the prevalence of inherited fibrinogen disorders through a systematic analysis of exome/genome data.

13. FGB c.490G>A indicated the activation of a cryptic splice site causing the insertion of 99 bp in intron 3. This splicing abnormality led to the production of a Bbeta-chain possessing 33 aberrant amino acids, including two Cys residues in the coiled-coil domain. Therefore, a splicing abnormality may cause impaired fibrinogen assembly and secretion.

14. Binding of human fibrinogen to MRP enhances Streptococcus suis survival in host blood in a alphaXbeta2 integrin-dependent manner.

15. FGB mutations leading to congenital hypofibrinogenaemia

16. Fibrinogen Bbeta448Lys variant is associated with thrombotic fibrin clots in type 2 diabetic patients independently of traditional risk factors.

17. There was underexpression of the majority of genes after sunitinib treatment. The lower expression levels of IGFBP1, CCL20, CXCL6 and FGB were confirmed by qRT-PCR in all cases. The downregulation of gene expression leads us to search for methylation as a mechanism of action of the tyrosine kinase inhibitors

18. elevated levels of plasma homocysteine /homocysteine thiolactone contribute to AD pathology via the Abeta-fibrin(ogen) interaction

19. Heterozygous FV Leiden, homozygous PAI-1 4G/4G, heterozygous MTHFR C677T, homozygous MTHFR A1298C, as much as the combined thrombophilic genotypes MTHFR 677T + ACE Iota/D, MTHFR 677T/1298C + ACE D/D, ACE I/D + b-fibrinogen -455 G/A, FV HR2 + b-fibrinogen -455 G/A showed a correlation as risk factors for Recurrent pregnancy loss.

20. procoagulant changes in fibrin metastructure appear to result from excessive carbonylation of fibrinogen, which may compensate for a decrease in fibrinogen level in patients with cirrhosis

Mouse (Murine) Fibrinogen beta Chain (FGB) interaction partners

1. Data suggest that the interaction between Abeta and fibrinogen may be an important contributor to the vascular abnormalities found in Alzheimer's disease.

2. beta(3) integrin, thrombin, and Ca(2+) play critical roles in platelet aggregation without fibrinogen or VWF

3. fibrin-derived peptide Bbeta(15-42) has a role in models of myocardial ischemia-reperfusion

Cow (Bovine) Fibrinogen beta Chain (FGB) interaction partners

1. two different approaches to tune the fibrillar structure and mechanical properties of fibrin hydrogels, are reported.

Pig (Porcine) Fibrinogen beta Chain (FGB) interaction partners

1. Data suggest the potential compensatory role of fibrinogen in restoring coagulation function in vivo after hemorrhagic shock.