Follistatin-Like 1 (FSTL1) ELISA Kits

Human Follistatin-Like 1 (FSTL1) interaction partners

1. Variant rs2272515 was found to significantly correlate (p < 0.05) with kyphoscoliosis.

2. An important role of Fstl1 in the regulation of temozolomide resistance by modulation of DIP2A/MGMT signaling.

3. current study revealed that low FSTL1, BMP4, and Smad4 expression significantly predict poor prognosis in lung adenocarcinoma but not in squamous cell carcinoma.

4. The FSTL1 decrease observed in extremely obese subjects is a result of adipogenesis reduction accompanied by a senescence of preadipocytes which otherwise willingly express FSTL1, increased adipocyte apoptosis, and epigenetic FSTL1 silencing.

5. In cultured human pulmonary artery smooth muscle cells, hypoxia-promoted cellular viability, DNA synthesis and migration were suppressed by exogenous FSTL1 but enhanced by small interfering RNA targeting FSTL1

6. Study suggests that follistatin like 1 plays an important role in lung fibrosis, and may serve as a novel therapeutic target for treatment of silicosis.

7. Segmental allergen challenge increases levels of airway follistatin-like 1 in patients with asthma.

8. Study found that FSTL1 was downregulated in non-small cell lung cancer (NSCLC) cells. FSTL1 overexpression suppressed tumor cell proliferation, altered cell cycle and induced apoptosis in addition to inhibiting cell survival, migration and invasion. Altogether, results revealed the critical tumor-suppression function of FSTL1 in NSCLC progression, suggesting it as an important factor in NSCLC progression.

9. Smad3 knockdown could restore the inhibition of cell proliferation induced by FSTL1 overexpression in MDAMB231FSTL1 cells, indicating that the antiproliferative effect of FSTL1 overexpression may be associated with Smad3 involved TGFbeta signaling pathway regulation. This study identified FSTL1 as an inhibitor of cell proliferation in MDAMB231 and 231BR cell lines

10. Dendritic cell-mediated immunity was activated by FSTL1.

11. Fstl1serves an important role in liver fibrosis and target deletion of Fstl1 attenuated HSCs activation through suppressing TGFbeta1/Smad3 signaling pathway.

12. Results showed that: 1- FSTL-1 expression is localized to the stromal compartment of the pancreas; 2- FSTL-1 expression is reduced in pancreatic cancer, and 3- FSTL-1 inhibited pancreatic cancer cell proliferation.

13. Data show that follistatin-like 1 (FSTL1) contributed to unfavorable post-surgical outcome of hepatocellular carcinoma (HCC) patients via inhibiting cell apoptosis.

14. results indicate that rs1259293 is associated with an increased risk and unfavorable postoperative prognosis of renal cell carcinoma, possibly by down-regulating FSTL1 expression in renal tissues.

15. Data provide evidence that FSTL1 modestly affects the proliferation of breast cancer cells and vascular endothelial cells. These findings improve the understanding of the functions of FSTL1 in breast cancer development and angiogenesis.

16. knockdown of FSTL1 inhibited ASM cell proliferation and migration induced by PDGF-BB at least partially via inhibiting the activation of ERK and AKT. These results provide novel insight into the pathogenesis of airway remodeling in childhood asthma and FSTL1 may be a possible therapeutic strategy for the treatment of asthma.

17. Fstl1 inhibited Smad1/5/8 phosphorylation by blocking the association between bone morphogenetic protein 4 and Bone Morphogenetic Protein Receptors, Type II via competitive binding to bone morphogenetic protein 4.

18. Data show that follistatin like-1 (FSTL1) was frequently downregulated in nasopharyngeal carcinoma (NPC) cell lines and primary tumor biopsies by promoter hypermethylation.

19. Results indicate the significance of follistatin-like protein 1 (FSTL1) in driving oncogenesis and metastasis in esophageal squamous cell carcinoma (ESCC) by coordinating NF-kappa B (NFkappaB) and bone morphogenetic proteins (BMP) pathway control.

20. FSTL1 mRNA levels increased in castration-resistant prostate cancer in association with predominantly nuclear FSTL1.

Mouse (Murine) Follistatin-Like 1 (FSTL1) interaction partners

1. Fstl1 is ubiquitously expressed at saccular stage in the developing lung. At E18.5, Fstl1 expression is robust in most type of mesenchymal cells

2. Haploinsufficiency of Fstl1 in mice contributed to an exacerbated hypoxia-induced Pulmonary hypertension, as demonstrated by increased right ventricular systolic pressure, pulmonary arterial muscularization and right ventricular hypertrophy index

3. this study shows that FSTL-1 modulates IL-17 signaling via IL-17RC regulation in stromal cells

4. FSTL1 may exert its actions through the modulation of Akt signaling.

5. FSTL1 is a secreted osteoclastogenic factor that plays a critical role in osteoclast formation via the NF-kappaB and MAPKs signaling pathways.

6. study indicates a pivotal role for Fstl1 in early stage of lung airway smooth muscle development

7. This study reveals that Fstl1 is essential for the acute repair of the infarcted myocardium and that stimulation of early fibroblast activation is a novel function of Fstl1.

8. Deletion of Fstl1 from the endocardial/endothelial lineage results in deformed mitral valves, which cause regurgitation, heart failure, and early cardiac death.

9. A critical role for the Smad3-c-Jun pathway in the regulation of Fstl1.

10. FSTL1 may induce epithelial mesenchymal transition and airway remodeling by activating autophagy.

11. tightly spatial interaction of FSTL1 and BMP4 signaling plays an essential role in lung development

12. a new role for FSTL1 in the development of radial glial scaffolds and the neuronal migration of upper-layer projection neurons, is reported.

13. administration of Fstl1 induced airway remodeling and increased OSM, whereas administration of an anti-OSM Ab blocked the effect of Fstl1 on inducing airway remodeling, eosinophilic airway inflammation

14. epicardial cells contain a potent cardiogenic activity identified as follistatin-like 1 (Fstl1)

15. FSTL1 is a potent regulator of chondrocyte proliferation, differentiation and expression of extracellular matrix molecules.

16. muscle-derived Fstl1 attenuates neointimal formation in response to arterial injury by suppressing smooth muscle cell proliferation through an AMPK-dependent mechanism

17. functions in cardiorenal communication; lack of Fstl1 production by myocytes promotes glomerular and tubulointerstitial damage in the kidney

18. Fstl1 is induced in response to lung injury and promotes the accumulation of myofibroblasts and subsequent fibrosis. These data suggest that Fstl1 may serve as a novel therapeutic target for treatment of progressive lung fibrosis.

19. FSTL1 is elevated in various inflammatory conditions and decreased during the course of treatment. FSTL1 may therefore be a valuable biomarker for such diseases.

20. This study is the first to describe a role for FSTL-1 in the development of Lyme arthritis and anti-Borrelia response.