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FOXC2 belongs to the forkhead family of transcription factors which is characterized by a distinct DNA-binding forkhead domain.
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Foxc2 influences alveolar epithelial cell differentiation during lung development
Study shows that alpha melanocyte stimulating hormone (show POMC ELISA Kits) and forkhead box C2 protein promote fatty acid oxidation through C/EBPbeta (show CEBPB ELISA Kits) negative transcription in mice adipose tissue.
FOXC1 (show FOXC1 ELISA Kits) and FOXC2 are essential regulators of lymphangiogenesis and may have roles in lymphatic-associated diseases
Compound, NC-specific Foxc1 (show FOXC1 ELISA Kits); Foxc2 homozygous mutant mice have more severe defects in structures of the ocular surface, such as the cornea and eyelids, accompanied by significant declines in the expression of another key developmental factor, Pitx2 (show PITX2 ELISA Kits), and its downstream effector Dkk2 (show DKK2 ELISA Kits), which antagonizes canonical Wnt (show WNT2 ELISA Kits) signaling.
Foxc1 (show FOXC1 ELISA Kits) and Foxc2 maintain glomerular podocyte integrity by regulating the gene expression. Foxc2 plays a more critical role than Foxc1 (show FOXC1 ELISA Kits).
Foxc1 (show FOXC1 ELISA Kits) and Foxc2 have a role in kidney and axial skeleton development.
Our results are consistent with previous reports of Foxc2 expression during early embryogenesis and the Foxc2(CreERT2) mouse provides a tool to investigate spatiotemporal roles of Foxc2 and contributions of Foxc2(+) expressing cells during mouse embryogenesis.
Conditional knockout of Foxc2 gene in kidney has been generated using conditional alleles of single-exon gene by double-selection system.
Data show that segregation of Foxc2 and NFATc1 transcription factor is closely associated with the highly polarized expression of connexins Cx37, Cx43, and Cx47.
deletion of Foxc1 (show FOXC1 ELISA Kits) and Foxc2 specifically in Pax3 (show PAX3 ELISA Kits)-positive cells affects cell fate choices in the dermomyotome of somites at forelimb level, promoting the myogenic cell fate at the expense of endothelial cells that migrate to the limb
The finding of rare LAMA5 (show LAMA5 ELISA Kits) variants together with FOXC2 mutations in lymphedema-distichiasis syndrome suggests that these mutations may be co-responsible for these disorders and most likely interfere with the function of lymphatics.
In FOXC2 knockdown cell lines, CXCR4 (show CXCR4 ELISA Kits), a downstream target of FOXC2, can restore osteosarcoma cell invasiveness and metastasis to the lung
Knockdown of FOXC2 inhibited HCC cell growth, migration, and invasion in vitro, as well as tumor growth.
Studied interactions between protein kinase C alpha (PKCalpha (show PKCa ELISA Kits)), FOXC2, and p120-catenin (CTNND1 (show CTNND1 ELISA Kits)) in breast cancer, cell migration/ invasion; found PKCalpha (show PKCa ELISA Kits) acts as an upstream regulator of FOXC2, which in turn represses the expression of p120-catenin (show CTNND1 ELISA Kits), in both in endocrine resistant ER+breast cancer and basal A triple negative breast cancer.
FOXC2 and CLIP4 activity correlates to the presence of =7-cm clear cell renal cell carcinomas (ccRCCs) with synchronous metastasis and may be potential molecular predictors of synchronous metastasis of =7-cm ccRCCs.
either a complete loss or a significant gain of FOXC2 function can cause a perturbation of lymphatic vessel formation leading to lymphedema.
Association of polymorphisms near the FOXC2 gene with the risk of varicose veins in ethnic Russians.
respectively. Foxc2 is expressed in the developing kidney and therefore congenital renal anomalies may well be associated, potentially as a low penetrance feature. We propose that all individuals diagnosed with Lymphedema distichiasis syndrome should have a baseline renal ultrasound scan at diagnosis
Genomic analysis of blood and excised valve tissue showed down-regulation of FOXC1 (show FOXC1 ELISA Kits) but also FOXC2 expression in the diseased aortic valve. This allows us to speculate on the potential role of FOXC1 (show FOXC1 ELISA Kits) in aortic valve anomalies.
This is the first report of a FOXC2 mutation in hereditary distichiasis in the Chinese population. The findings expand the FOXC2 mutation spectrum and contribute to the understanding of the genotype-phenotype correlation of this disease.
This gene belongs to the forkhead family of transcription factors which is characterized by a distinct DNA-binding forkhead domain. The specific function of this gene has not yet been determined\; however, it may play a role in the development of mesenchymal tissues.
forkhead box C2 (MFH-1, mesenchyme forkhead 1)
, forkhead box C2
, forkhead box protein C2
, forkhead box protein C2-like
, brain factor 3
, forkhead homolog 14
, forkhead-related protein FKHL14
, mesenchyme fork head protein 1
, transcription factor FKH-14
, forkhead box C2 (MFH-1 mesenchyme forkhead 1)
, winged helix transcriptional factor MFH-1
, MFH-1,mesenchyme forkhead 1
, forkhead, Drosophila, homolog-like 14