anti-Forkhead Box P2 (FOXP2) Antibodies

Human Forkhead Box P2 (FOXP2) interaction partners

1. To examine whether the variant in the FOXP2 gene contributes toward SCZ susceptibility, we carried out an association analysis of the SNP rs10447760 of the FOXP2 gene in a case-control study (1405 cases, 1137 controls) from China. We identified no association of rs10447760 in the FOXP2 gene with SCZ (P>0.05). A meta-analysis indicated that the SNP rs10447760 was not associated with susceptibility to SCZ in Han Chinese.

2. These findings suggest a novel miR-23a/FOXP2 link contributing to pancreatic ductal adenocarcinoma development and invasion.

3. Data confirmed that miR196b could directly bind to 3'UTR of FOXP2 mRNA and repress its expression. miR196b and FOXP2 showed a negative correlation in HCC tissues. More importantly, upregulation of FOXP2 antagonized miR196bmediated migration and invasion in Hep3B cells. Furthermore, FOXP2 knockdown partially reversed the antimetastatic function of the miR196b inhibitor on HCCLM3 cells.

4. SNPs in WNT2 and FOXP2 are associated with clinical symptom severity of autism spectrum disorders.

5. we have identified a novel de novo missense variant in FOXP1 that is identical to the most well-studied etiological variant in FOXP2. Functional characterization revealed clear similarities between these equivalent mutations in terms of their impact on protein function.

6. FOXP2 anomaly is either directly or indirectly associated with atypical development of widespread subcortical networks early in life.

7. Our findings suggest that the FOXP2 rs10447760 polymorphism may not contribute to the development of schizophrenia, but may contribute to the clinical symptoms of schizophrenia among Han Chinese

8. FOXP2 frontal cortex expression abnormalities were identified in Frontotemporal Degeneration patients.

9. Increased frequency of FOXP2 expression significantly correlated with FOXP1-positivity, and FOXP1 co-immunoprecipitated FOXP2 from activated B-cell-diffuse large B-cell lymphoma (ABC-DLBCL) cells.

10. These findings suggest that miR-139 plays a suppressive role in the regulation of osteosarcoma cell proliferation and migration via directly targeting FOXP2.

11. results provide evidence that FOXP2 SNPs influence aspects of human inner speech and fluency that are related to lateralized phenotypes, and suggest that the evolution of human language, as mediated by the adaptive evolution of FOXP2, involved features of inner speech

12. An intragenic deletion in FOXP2.

13. The proposes a binding model for the FOXP2 FHD that involves three types of binding sequence: low affinity sites which allow for rapid scanning of the genome by the protein in a partially unstructured state; moderate affinity sites which serve to locate the protein near target sites and high-affinity sites which secure the protein to the DNA .

14. FOXP2 can be modified with all three human SUMO proteins and that PIAS1 promotes this process.

15. FOXP2 is a substrate for SUMOylation and SUMOylation of FOXP2 plays a functional role in regulating its transcriptional activity.

16. CNTNAP2 is transcriptionally regulated by FOXP2.

17. Data suggest FOXP2 binds DNA as monomer; FOXP2 hinge loop domain mutants exhibit either decreased formation of homodimer (A539P) or decreased dissociation of homodimer (F541C); naturally occurring reverse mutation (P539A) increases DNA binding affinity.

18. Genetic variants in FOXP2 may be significant for rare forms of language impairment, they do not contribute appreciably to individual variation in the normal range as found in the general population.

19. Our results suggested that FOXP2 expression was downregulated in Hepatocellular carcinoma tumor tissues, and reduced FOXP2 expression was associated with poor overall survival

20. TBR1 homodimerizes; it interacts with FOXP2, a transcription factor implicated in speech/language disorders, and this interaction is disrupted by pathogenic mutations affecting either protein

Mouse (Murine) Forkhead Box P2 (FOXP2) interaction partners

1. findings also indicate that Foxp2 helps to regulate strength and length of hind limbs and maintenance of joint cartilage and intervertebral discs, which are all anatomical features that are susceptible to adaptations for bipedal locomotion.

2. Foxp2 has a putative HuR binding sites in the 3' UTR. Phosphorylation sites on HuR act in post-transcriptional regulation of Foxp2.

3. The expression levels of Foxp2 were high in the posterior region and low in the anterior region of the thalamic primordium.

4. Here, the authors show that the telencephalic preoptic area is comprised of distinct progenitor pools complementarily marked by the transcription factors Dbx1 and Foxp2. As determined by molecular and electrophysiological criteria this embryonic parcellation predicts postnatal medial subnucleus of the amygdala inhibitory neuronal subtype identity.

5. Eesults indicate a role of FoxP2 differential expression in cell morphology control of the vertebrate telencephalon.

6. that Foxp2-Mef2C signaling is critical to corticostriatal circuit formation

7. Sumoylation of forkhead box P2 in neonatal mouse cerebellum regulates Purkinje cell development and motor functions and vocal communication, demonstrating evidence for sumoylation in regulating mammalian behaviors.

8. we demonstrated for the first time that Foxp1 and Foxp2 are expressed during craniofacial development. Our data suggest that the Foxp genes may regulate development of the aboral and posterior regions of the jaw.

9. Combined loss of all three Foxp1/2/4 family members in the developing anterior foregut endoderm leads to a loss of lung endoderm lineage commitment and subsequent development. Foxp1/2/4 deficient lungs express high levels of transcriptional regulators not normally expressed in developing lung. Ectopic expression of these transcriptional regulators is accompanied by decreased expression of lung restricted transcription.

10. We show that Foxp1 and the androgen receptor are co-expressed in striatal medium spiny neurons and that brain-specific androgen receptor KO (ArNesCre) mice exhibit reduced Foxp1 expression in the striatum at E17.5 and P7.5 and an increased Foxp2 level in the cortex at P7.5. Thus, androgens may contribute to sex-specific differences in Foxp1 and Foxp2 expression and ultrasonic vocalizations

11. The Foxp2 gene is critical for normal vocal behavior in juvenile and adult mice.

12. This study demonstrated that after middle cerebral artery occlusion mice demonstrate profoundly impaired socially evoked USVs and suppression of the language-associated transcription factor, Forkhead box protein 2 (Foxp2).

13. mice with Foxp2 mutations displayed quantitative differences in ultrasonic vocalizations as compared to wild-types

14. Collectively, these findings reveal an important role for the FOXP1, 2, and 4 proteins in governing postnatal alpha cell expansion and function.

15. Foxp2 was elevated early after stroke (at 6h), but significantly decreased 24h after injury in both the nucleus and the cytoplasm; neuronal Foxp2 expression increased in stroke mice compared to sham animals 4 weeks after injury

16. arkypallidal GPe neurons originate from lateral/caudal ganglionic eminences, express the transcription factor FoxP2, fire at low rates during rest, and encode movements with robust increases in firing.

17. Foxp1/2/4 may regulate Runx2 during endochondral ossification.

18. Results suggest that Foxp2 regulates multiple aspects of neuronal development in the embryonic forebrain

19. Foxp2 in Purkinje cells may pertain to the brain network engaged in ultrasonic vocalization (USV) modification, including USV duration, but not USV production

20. results indicate that FOXP2 is critical for the function of striatal circuits.

Zebrafish Forkhead Box P2 (FOXP2) interaction partners

1. Our findings suggest that foxP2 is not necessary for axon pathfinding during development.

2. foxP2 likely has a more general conserved role in nervous system development; molecular cloning

3. The developing optic tectum becomes the major area of FoxP2 expression. In the adult brain, the highest concentrations of the FoxP2 transcript can be observed in the optic tectum.

4. Domain-specific regulation of foxP2 CNS expression by lef1.