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FOXP2 encodes a member of the forkhead/winged-helix (FOX) family of transcription factors. Additionally we are shipping FOXP2 Proteins (6) and and many more products for this protein.
Showing 10 out of 144 products:
Human Polyclonal FOXP2 Primary Antibody for ICC, IHC (fro) - ABIN188687
Lai, Fisher, Hurst, Vargha-Khadem, Monaco: A forkhead-domain gene is mutated in a severe speech and language disorder. in Nature 2001
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Human Polyclonal FOXP2 Primary Antibody for ICC, IF - ABIN4312409
Enard, Gehre, Hammerschmidt, Hölter, Blass, Somel, Brückner, Schreiweis, Winter, Sohr, Becker, Wiebe, Nickel, Giger, Müller, Groszer, Adler, Aguilar, Bolle, Calzada-Wack, Dalke, Ehrhardt, Favor et al.: A humanized version of Foxp2 affects cortico-basal ganglia circuits in mice. ... in Cell 2009
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Human Monoclonal FOXP2 Primary Antibody for ELISA, WB - ABIN969154
Konopka, Bomar, Winden, Coppola, Jonsson, Gao, Peng, Preuss, Wohlschlegel, Geschwind: Human-specific transcriptional regulation of CNS development genes by FOXP2. in Nature 2009
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Human Monoclonal FOXP2 Primary Antibody for ELISA, WB - ABIN969155
Ptak, Enard, Wiebe, Hellmann, Krause, Lachmann, Pääbo: Linkage disequilibrium extends across putative selected sites in FOXP2. in Molecular biology and evolution 2009
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Human Polyclonal FOXP2 Primary Antibody for IHC, ELISA - ABIN263146
Fujita, Sugihara: FoxP2 expression in the cerebellum and inferior olive: development of the transverse stripe-shaped expression pattern in the mouse cerebellar cortex. in The Journal of comparative neurology 2011
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Human Polyclonal FOXP2 Primary Antibody for IHC, ELISA - ABIN334400
Fujita, Morita, Furuichi, Sugihara: Clustered fine compartmentalization of the mouse embryonic cerebellar cortex and its rearrangement into the postnatal striped configuration. in The Journal of neuroscience : the official journal of the Society for Neuroscience 2012
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Human Polyclonal FOXP2 Primary Antibody for IF, WB - ABIN651939
Margolis, Abraham, Gatchell, Li, Kidwai, Breschel, Stine, Callahan, McInnis, Ross: cDNAs with long CAG trinucleotide repeats from human brain. in Human genetics 1997
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These findings suggest a novel miR (show MLXIP Antibodies)-23a/FOXP2 link contributing to pancreatic ductal adenocarcinoma development and invasion.
Data confirmed that miR196b could directly bind to 3'UTR (show UTS2R Antibodies) of FOXP2 mRNA and repress its expression. miR196b and FOXP2 showed a negative correlation in HCC (show FAM126A Antibodies) tissues. More importantly, upregulation of FOXP2 antagonized miR196bmediated migration and invasion in Hep3B cells. Furthermore, FOXP2 knockdown partially reversed the antimetastatic function of the miR196b inhibitor on HCCLM3 cells.
SNPs in WNT2 (show WNT2 Antibodies) and FOXP2 are associated with clinical symptom severity of autism spectrum disorders.
we have identified a novel de novo missense variant in FOXP1 (show FOXP1 Antibodies) that is identical to the most well-studied etiological variant in FOXP2. Functional characterization revealed clear similarities between these equivalent mutations in terms of their impact on protein function.
FOXP2 anomaly is either directly or indirectly associated with atypical development of widespread subcortical networks early in life.
Our findings suggest that the FOXP2 rs10447760 polymorphism may not contribute to the development of schizophrenia, but may contribute to the clinical symptoms of schizophrenia among Han Chinese
FOXP2 frontal cortex expression abnormalities were identified in Frontotemporal Degeneration patients.
Increased frequency of FOXP2 expression significantly correlated with FOXP1 (show FOXP1 Antibodies)-positivity, and FOXP1 (show FOXP1 Antibodies) co-immunoprecipitated FOXP2 from activated B-cell-diffuse large B-cell lymphoma (ABC (show ABCB6 Antibodies)-DLBCL) cells.
These findings suggest that miR (show MLXIP Antibodies)-139 plays a suppressive role in the regulation of osteosarcoma cell proliferation and migration via directly targeting FOXP2.
results provide evidence that FOXP2 SNPs influence aspects of human inner speech and fluency that are related to lateralized phenotypes, and suggest that the evolution of human language, as mediated by the adaptive evolution of FOXP2, involved features of inner speech
findings also indicate that Foxp2 helps to regulate strength and length of hind limbs and maintenance of joint cartilage and intervertebral discs, which are all anatomical features that are susceptible to adaptations for bipedal locomotion.
Foxp2 has a putative HuR (show ELAVL1 Antibodies) binding sites in the 3' UTR (show UTS2R Antibodies). Phosphorylation sites on HuR (show ELAVL1 Antibodies) act in post-transcriptional regulation of Foxp2.
The expression levels of Foxp2 were high in the posterior region and low in the anterior region of the thalamic primordium.
Here, the authors show that the telencephalic preoptic area is comprised of distinct progenitor pools complementarily marked by the transcription factors Dbx1 (show DBX1 Antibodies) and Foxp2. As determined by molecular and electrophysiological criteria this embryonic parcellation predicts postnatal medial subnucleus of the amygdala inhibitory neuronal subtype identity.
Eesults indicate a role of FoxP2 differential expression in cell morphology control of the vertebrate telencephalon.
that Foxp2-Mef2C (show MEF2C Antibodies) signaling is critical to corticostriatal circuit formation
Sumoylation of forkhead box P2 in neonatal mouse cerebellum regulates Purkinje cell development and motor functions and vocal communication, demonstrating evidence for sumoylation in regulating mammalian behaviors.
we demonstrated for the first time that Foxp1 (show FOXP1 Antibodies) and Foxp2 are expressed during craniofacial development. Our data suggest that the Foxp genes may regulate development of the aboral and posterior regions of the jaw.
Combined loss of all three Foxp1 (show FOXP1 Antibodies)/2/4 family members in the developing anterior foregut endoderm leads to a loss of lung endoderm lineage commitment and subsequent development. Foxp1 (show FOXP1 Antibodies)/2/4 deficient lungs express high levels of transcriptional regulators not normally expressed in developing lung. Ectopic expression of these transcriptional regulators is accompanied by decreased expression of lung restricted transcription.
We show that Foxp1 (show FOXP1 Antibodies) and the androgen receptor (show AR Antibodies) are co-expressed in striatal medium spiny neurons and that brain-specific (show CALY Antibodies) androgen receptor (show AR Antibodies) KO (ArNesCre) mice exhibit reduced Foxp1 (show FOXP1 Antibodies) expression in the striatum at E17.5 and P7.5 and an increased Foxp2 level in the cortex at P7.5. Thus, androgens may contribute to sex-specific differences in Foxp1 (show FOXP1 Antibodies) and Foxp2 expression and ultrasonic vocalizations
Our findings suggest that foxP2 is not necessary for axon pathfinding during development.
foxP2 likely has a more general conserved role in nervous system development; molecular cloning
The developing optic tectum becomes the major area of FoxP2 expression. In the adult brain, the highest concentrations of the FoxP2 transcript can be observed in the optic tectum.
Domain-specific regulation of foxP2 CNS expression by lef1 (show LEF1 Antibodies).
This gene encodes a member of the forkhead/winged-helix (FOX) family of transcription factors. It is expressed in fetal and adult brain as well as in several other organs such as the lung and gut. The protein product contains a FOX DNA-binding domain and a large polyglutamine tract and is an evolutionarily conserved transcription factor, which may bind directly to approximately 300 to 400 gene promoters in the human genome to regulate the expression of a variety of genes. This gene is required for proper development of speech and language regions of the brain during embryogenesis, and may be involved in a variety of biological pathways and cascades that may ultimately influence language development. Mutations in this gene cause speech-language disorder 1 (SPCH1), also known as autosomal dominant speech and language disorder with orofacial dyspraxia. Multiple alternative transcripts encoding different isoforms have been identified in this gene.
CAG repeat protein 44
, forkhead box protein P2
, forkhead/winged-helix transcription factor
, trinucleotide repeat containing 10
, trinucleotide repeat-containing gene 10 protein
, forkhead box P2
, transcription factor FoxP2
, forkhead box P protein
, forkhead box transcription factor