anti-Forkhead Box P2 (FOXP2) Antibodies

Human Forkhead Box P2 (FOXP2) interaction partners

1. In the presence of DNA, magnesium or calcium ions bind a single conserved binding pocket in the forkhead domain to promote a change in protein conformation that fosters the interaction between FOXP2 and DNA. In the absence of DNA, the metal ions bind this pocket weakly.

2. FOXP2 knockdown attenuated the growth and invasiveness of triple-negative breast cancer cells as well as tumor progression and metastasis.

3. FOXP2 rs10447760 polymorphism is associated with increased risk of schizophrenia in Caucasian but not Chinese populations.

4. This is the most comprehensive analysis to date and indicates that common variants in FOXP2 do not play a major role in speech and language development in a clinical family sample.

5. The change in dynamics of the hinge-loop region of FOXP2 alters the energetics and mechanism of DNA binding highlighting the critical role of hinge loop mutations in regulating DNA binding characteristics of the FOX proteins.

6. FOXP2 is involved in the development of Orofacial Dyspraxia in Specific Language Impairment, highlighting the relevant role that the FOXP2-CNTNAP2 pathway plays in the emergence of language disorders.

7. etiological mutations of FOXP1 and FOXP2, known to cause neurodevelopmental disorders, severely disrupted the interactions with FOXP-interacting transcription factors.

8. Study investigated the effect of the FOXP2 mutation on Working Memory using members of the KE family; found mutation caused impairment in articulation that extends to working memory, presumably including the internal rehearsal of speech-based material, and that this extension of speech-related difficulty appears to be due to the same structural abnormalities that cause the articulatory disorder.

9. To examine whether the variant in the FOXP2 gene contributes toward SCZ susceptibility, we carried out an association analysis of the SNP rs10447760 of the FOXP2 gene in a case-control study (1405 cases, 1137 controls) from China. We identified no association of rs10447760 in the FOXP2 gene with SCZ (P>0.05). A meta-analysis indicated that the SNP rs10447760 was not associated with susceptibility to SCZ in Han Chinese.

10. These findings suggest a novel miR-23a/FOXP2 link contributing to pancreatic ductal adenocarcinoma development and invasion.

11. Data confirmed that miR196b could directly bind to 3'UTR of FOXP2 mRNA and repress its expression. miR196b and FOXP2 showed a negative correlation in HCC tissues. More importantly, upregulation of FOXP2 antagonized miR196bmediated migration and invasion in Hep3B cells. Furthermore, FOXP2 knockdown partially reversed the antimetastatic function of the miR196b inhibitor on HCCLM3 cells.

12. SNPs in WNT2 and FOXP2 are associated with clinical symptom severity of autism spectrum disorders.

13. we have identified a novel de novo missense variant in FOXP1 that is identical to the most well-studied etiological variant in FOXP2. Functional characterization revealed clear similarities between these equivalent mutations in terms of their impact on protein function.

14. FOXP2 anomaly is either directly or indirectly associated with atypical development of widespread subcortical networks early in life.

15. Our findings suggest that the FOXP2 rs10447760 polymorphism may not contribute to the development of schizophrenia, but may contribute to the clinical symptoms of schizophrenia among Han Chinese

16. FOXP2 frontal cortex expression abnormalities were identified in Frontotemporal Degeneration patients.

17. Increased frequency of FOXP2 expression significantly correlated with FOXP1-positivity, and FOXP1 co-immunoprecipitated FOXP2 from activated B-cell-diffuse large B-cell lymphoma (ABC-DLBCL) cells.

18. These findings suggest that miR-139 plays a suppressive role in the regulation of osteosarcoma cell proliferation and migration via directly targeting FOXP2.

19. results provide evidence that FOXP2 SNPs influence aspects of human inner speech and fluency that are related to lateralized phenotypes, and suggest that the evolution of human language, as mediated by the adaptive evolution of FOXP2, involved features of inner speech

20. An intragenic deletion in FOXP2.

Mouse (Murine) Forkhead Box P2 (FOXP2) interaction partners

1. Study quantitatively analyzes the expression pattern of Foxp1 and Foxp2 with respect to specific cell types of projection neurons and interneurons in the striatum of adult mouse brains. Double immunostaining and in situ hybridization showed that Foxp1 and Foxp2 were specifically expressed in striatal projection neurons, but not in interneurons.

2. Study shows that heterozygous loss of Foxp2 decreases excitatory (AMPA receptor-mediated) and increases inhibitory (GABA receptor-mediated) currents in D1 dopamine receptor positive MSNs of juvenile and adult mice.

3. miR-34a and its target genes of FOXP2 and VAT1 are involved in dorsal root ganglia neuron damage under hyperglycemia.

4. findings also indicate that Foxp2 helps to regulate strength and length of hind limbs and maintenance of joint cartilage and intervertebral discs, which are all anatomical features that are susceptible to adaptations for bipedal locomotion.

5. Foxp2 has a putative HuR binding sites in the 3' UTR. Phosphorylation sites on HuR act in post-transcriptional regulation of Foxp2.

6. The expression levels of Foxp2 were high in the posterior region and low in the anterior region of the thalamic primordium.

7. Here, the authors show that the telencephalic preoptic area is comprised of distinct progenitor pools complementarily marked by the transcription factors Dbx1 and Foxp2. As determined by molecular and electrophysiological criteria this embryonic parcellation predicts postnatal medial subnucleus of the amygdala inhibitory neuronal subtype identity.

8. Eesults indicate a role of FoxP2 differential expression in cell morphology control of the vertebrate telencephalon.

9. that Foxp2-Mef2C signaling is critical to corticostriatal circuit formation

10. Sumoylation of forkhead box P2 in neonatal mouse cerebellum regulates Purkinje cell development and motor functions and vocal communication, demonstrating evidence for sumoylation in regulating mammalian behaviors.

11. we demonstrated for the first time that Foxp1 and Foxp2 are expressed during craniofacial development. Our data suggest that the Foxp genes may regulate development of the aboral and posterior regions of the jaw.

12. Combined loss of all three Foxp1/2/4 family members in the developing anterior foregut endoderm leads to a loss of lung endoderm lineage commitment and subsequent development. Foxp1/2/4 deficient lungs express high levels of transcriptional regulators not normally expressed in developing lung. Ectopic expression of these transcriptional regulators is accompanied by decreased expression of lung restricted transcription.

13. We show that Foxp1 and the androgen receptor are co-expressed in striatal medium spiny neurons and that brain-specific androgen receptor KO (ArNesCre) mice exhibit reduced Foxp1 expression in the striatum at E17.5 and P7.5 and an increased Foxp2 level in the cortex at P7.5. Thus, androgens may contribute to sex-specific differences in Foxp1 and Foxp2 expression and ultrasonic vocalizations

14. The Foxp2 gene is critical for normal vocal behavior in juvenile and adult mice.

15. This study demonstrated that after middle cerebral artery occlusion mice demonstrate profoundly impaired socially evoked USVs and suppression of the language-associated transcription factor, Forkhead box protein 2 (Foxp2).

16. mice with Foxp2 mutations displayed quantitative differences in ultrasonic vocalizations as compared to wild-types

17. Collectively, these findings reveal an important role for the FOXP1, 2, and 4 proteins in governing postnatal alpha cell expansion and function.

18. Foxp2 was elevated early after stroke (at 6h), but significantly decreased 24h after injury in both the nucleus and the cytoplasm; neuronal Foxp2 expression increased in stroke mice compared to sham animals 4 weeks after injury

19. arkypallidal GPe neurons originate from lateral/caudal ganglionic eminences, express the transcription factor FoxP2, fire at low rates during rest, and encode movements with robust increases in firing.

20. Foxp1/2/4 may regulate Runx2 during endochondral ossification.

Zebrafish Forkhead Box P2 (FOXP2) interaction partners

1. Our findings suggest that foxP2 is not necessary for axon pathfinding during development.

2. foxP2 likely has a more general conserved role in nervous system development; molecular cloning

3. The developing optic tectum becomes the major area of FoxP2 expression. In the adult brain, the highest concentrations of the FoxP2 transcript can be observed in the optic tectum.

4. Domain-specific regulation of foxP2 CNS expression by lef1.