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FOXP2 encodes a member of the forkhead/winged-helix (FOX) family of transcription factors.
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SNPs in WNT2 (show WNT2 Proteins) and FOXP2 are associated with clinical symptom severity of autism spectrum disorders.
we have identified a novel de novo missense variant in FOXP1 (show FOXP1 Proteins) that is identical to the most well-studied etiological variant in FOXP2. Functional characterization revealed clear similarities between these equivalent mutations in terms of their impact on protein function.
FOXP2 anomaly is either directly or indirectly associated with atypical development of widespread subcortical networks early in life.
Our findings suggest that the FOXP2 rs10447760 polymorphism may not contribute to the development of schizophrenia, but may contribute to the clinical symptoms of schizophrenia among Han Chinese
FOXP2 frontal cortex expression abnormalities were identified in Frontotemporal Degeneration patients.
Increased frequency of FOXP2 expression significantly correlated with FOXP1 (show FOXP1 Proteins)-positivity, and FOXP1 (show FOXP1 Proteins) co-immunoprecipitated FOXP2 from activated B-cell-diffuse large B-cell lymphoma (ABC (show ABCB6 Proteins)-DLBCL) cells.
These findings suggest that miR (show MLXIP Proteins)-139 plays a suppressive role in the regulation of osteosarcoma cell proliferation and migration via directly targeting FOXP2.
results provide evidence that FOXP2 SNPs influence aspects of human inner speech and fluency that are related to lateralized phenotypes, and suggest that the evolution of human language, as mediated by the adaptive evolution of FOXP2, involved features of inner speech
An intragenic deletion in FOXP2.
The proposes a binding model for the FOXP2 FHD that involves three types of binding sequence: low affinity sites which allow for rapid scanning of the genome by the protein in a partially unstructured state; moderate affinity sites which serve to locate the protein near target sites and high-affinity sites which secure the protein to the DNA .
Foxp2 has a putative HuR (show ELAVL1 Proteins) binding sites in the 3' UTR. Phosphorylation sites on HuR (show ELAVL1 Proteins) act in post-transcriptional regulation of Foxp2.
The expression levels of Foxp2 were high in the posterior region and low in the anterior region of the thalamic primordium.
Here, the authors show that the telencephalic preoptic area is comprised of distinct progenitor pools complementarily marked by the transcription factors Dbx1 (show DBX1 Proteins) and Foxp2. As determined by molecular and electrophysiological criteria this embryonic parcellation predicts postnatal medial subnucleus of the amygdala inhibitory neuronal subtype identity.
Eesults indicate a role of FoxP2 differential expression in cell morphology control of the vertebrate telencephalon.
that Foxp2-Mef2C (show MEF2C Proteins) signaling is critical to corticostriatal circuit formation
Sumoylation of forkhead box P2 in neonatal mouse cerebellum regulates Purkinje cell development and motor functions and vocal communication, demonstrating evidence for sumoylation in regulating mammalian behaviors.
we demonstrated for the first time that Foxp1 (show FOXP1 Proteins) and Foxp2 are expressed during craniofacial development. Our data suggest that the Foxp genes may regulate development of the aboral and posterior regions of the jaw.
Combined loss of all three Foxp1 (show FOXP1 Proteins)/2/4 family members in the developing anterior foregut endoderm leads to a loss of lung endoderm lineage commitment and subsequent development. Foxp1 (show FOXP1 Proteins)/2/4 deficient lungs express high levels of transcriptional regulators not normally expressed in developing lung. Ectopic expression of these transcriptional regulators is accompanied by decreased expression of lung restricted transcription.
We show that Foxp1 (show FOXP1 Proteins) and the androgen receptor (show AR Proteins) are co-expressed in striatal medium spiny neurons and that brain-specific (show CALY Proteins) androgen receptor (show AR Proteins) KO (ArNesCre) mice exhibit reduced Foxp1 (show FOXP1 Proteins) expression in the striatum at E17.5 and P7.5 and an increased Foxp2 level in the cortex at P7.5. Thus, androgens may contribute to sex-specific differences in Foxp1 (show FOXP1 Proteins) and Foxp2 expression and ultrasonic vocalizations
The Foxp2 gene is critical for normal vocal behavior in juvenile and adult mice.
Our findings suggest that foxP2 is not necessary for axon pathfinding during development.
foxP2 likely has a more general conserved role in nervous system development; molecular cloning
The developing optic tectum becomes the major area of FoxP2 expression. In the adult brain, the highest concentrations of the FoxP2 transcript can be observed in the optic tectum.
Domain-specific regulation of foxP2 CNS expression by lef1 (show LEF1 Proteins).
This gene encodes a member of the forkhead/winged-helix (FOX) family of transcription factors. It is expressed in fetal and adult brain as well as in several other organs such as the lung and gut. The protein product contains a FOX DNA-binding domain and a large polyglutamine tract and is an evolutionarily conserved transcription factor, which may bind directly to approximately 300 to 400 gene promoters in the human genome to regulate the expression of a variety of genes. This gene is required for proper development of speech and language regions of the brain during embryogenesis, and may be involved in a variety of biological pathways and cascades that may ultimately influence language development. Mutations in this gene cause speech-language disorder 1 (SPCH1), also known as autosomal dominant speech and language disorder with orofacial dyspraxia. Multiple alternative transcripts encoding different isoforms have been identified in this gene.
CAG repeat protein 44
, forkhead box protein P2
, forkhead/winged-helix transcription factor
, trinucleotide repeat containing 10
, trinucleotide repeat-containing gene 10 protein
, forkhead box P2
, transcription factor FoxP2
, forkhead box P protein
, forkhead box transcription factor