anti-Four and A Half LIM Domains 1 (FHL1) Antibodies

FHL1 encodes a member of the four-and-a-half-LIM-only protein family. Additionally we are shipping Four and A Half LIM Domains 1 Proteins (11) and Four and A Half LIM Domains 1 Kits (8) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
FHL1 2273 Q13642
FHL1 14199 P97447
FHL1 25177 Q9WUH4
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Top anti-Four and A Half LIM Domains 1 Antibodies at

Showing 10 out of 115 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Delivery Price Details
Human Rabbit Un-conjugated IC, IF, WB 200 μL 13 to 14 Days
Cow Rabbit Un-conjugated IHC, WB Human kidney WB Suggested Anti-FHL1 Antibody Titration:  0.1ug/ml  ELISA Titer:  1:312500  Positive Control:  Human Muscle 100 μL 2 to 3 Days
Cow Rabbit Un-conjugated WB Host: Mouse Target Name: FHL1 Sample Tissue: Mouse Testis Antibody Dilution: 1ug/ml Host: Rabbit Target Name: FHL1 Sample Type: Human Fetal Brain Antibody Dilution: 1.0ug/ml 100 μL 2 to 3 Days
Human Goat Un-conjugated IHC, ELISA, WB ABIN185289 staining (0.05µg/ml) of Human Muscle lysate (RIPA buffer, 35µg total protein per lane). Primary incubated for 1 hour. Detected by western blot using chemiluminescence. ABIN185289 (2.5µg/ml) staining of paraffin embedded Human Testis. Steamed antigen retrieval with citrate buffer pH 6, AP-staining. 100 μg 6 to 7 Days
Human Goat Un-conjugated ELISA, WB ABIN185290 (0.01µg/ml) staining of Human Heart lysate (35µg protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence. 100 μg 6 to 7 Days
Human Mouse Un-conjugated FACS, WB 100 μL 11 to 14 Days
Dog Mouse Un-conjugated FACS, IF, WB 100 μL 11 to 14 Days
Human Rabbit Un-conjugated WB WB Image Sample (30 ug of whole cell lysate) A: Hela 10% SDS PAGE antibody diluted at 1:1000 100 μL 3 to 4 Days
Human Rabbit Un-conjugated EIA, WB 0.4 mL 6 to 8 Days
Hamster Goat Un-conjugated ELISA, IHC, IHC (p), WB Human Testis (formalin-fixed, paraffin-embedded) stained with FHL1 antibody ABIN337221 at 2.5 ug/ml followed by biotinylated anti-goat IgG secondary antibody ABIN481715, alkaline phosphatase-streptavidin and chromogen. Anti-FHL1 antibody IHC of human testis. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml. 50 μg 11 to 14 Days

Top referenced anti-Four and A Half LIM Domains 1 Antibodies

  1. Cow (Bovine) Polyclonal FHL1 Primary Antibody for IHC, WB - ABIN2775759 : McGrath, Mitchell, Coghill, Robinson, Brown: Skeletal muscle LIM protein 1 (SLIM1/FHL1) induces alpha 5 beta 1-integrin-dependent myocyte elongation. in American journal of physiology. Cell physiology 2003 (PubMed)
    Show all 12 Pubmed References

  2. Human Polyclonal FHL1 Primary Antibody for IHC, ELISA - ABIN185289 : Brown, McGrath, Ooms, Gurung, Maimone, Mitchell et al.: Characterization of two isoforms of the skeletal muscle LIM protein 1, SLIM1. Localization of SLIM1 at focal adhesions and the isoform slimmer in the nucleus of myoblasts and cytoplasm of myotubes ... in The Journal of biological chemistry 1999 (PubMed)
    Show all 4 Pubmed References

  3. Human Polyclonal FHL1 Primary Antibody for ELISA, WB - ABIN250290 : Zhang, Chen, Sharma, Moon, Sheftel, Dawood, Nghiem, Wu, Li, Gramolini, Sorensen, Penninger, Brumell, Liu: HACE1-dependent protein degradation provides cardiac protection in response to haemodynamic stress. in Nature communications 2014 (PubMed)
    Show all 2 Pubmed References

  4. Human Polyclonal FHL1 Primary Antibody for IHC (p), IHC - ABIN250288 : Gramolini, Kislinger, Alikhani-Koopaei, Fong, Thompson, Isserlin, Sharma, Oudit, Trivieri, Fagan, Kannan, Higgins, Huedig, Hess, Arab, Seidman, Seidman, Frey, Perry, Backx, Liu, MacLennan, Emili: Comparative proteomics profiling of a phospholamban mutant mouse model of dilated cardiomyopathy reveals progressive intracellular stress responses. in Molecular & cellular proteomics : MCP 2008 (PubMed)
    Show all 2 Pubmed References

  5. Human Monoclonal FHL1 Primary Antibody for ELISA, WB - ABIN515655 : Sakashita, Mimori, Tanaka, Kamohara, Inoue, Sawada, Hirakawa, Mori: Clinical significance of loss of Fhl1 expression in human gastric cancer. in Annals of surgical oncology 2008 (PubMed)

  6. Human Monoclonal FHL1 Primary Antibody for ELISA, WB - ABIN560899 : Chen, Ferrington, Thompson: Carbonic anhydrase III and four-and-a-half LIM protein 1 are preferentially oxidized with muscle unloading. in Journal of applied physiology (Bethesda, Md. : 1985) 2008 (PubMed)

  7. Human Polyclonal FHL1 Primary Antibody for ICC, IF - ABIN4311629 : Ek, Andréasson, Hober, Kampf, Pontén, Uhlén, Merz, Borrebaeck: From gene expression analysis to tissue microarrays: a rational approach to identify therapeutic and diagnostic targets in lymphoid malignancies. in Molecular & cellular proteomics : MCP 2006 (PubMed)

  8. Cow (Bovine) Polyclonal FHL1 Primary Antibody for IHC (p), ELISA - ABIN2473617 : Emmanuele, Kubota, Garcia-Diaz, Garone, Akman, Sánchez-Gutiérrez, Escudero, Kariya, Homma, Tanji, Quinzii, Hirano: Fhl1 W122S causes loss of protein function and late-onset mild myopathy. in Human molecular genetics 2015 (PubMed)

More Antibodies against Four and A Half LIM Domains 1 Interaction Partners

Human Four and A Half LIM Domains 1 (FHL1) interaction partners

  1. Based on bioinformatic analysis, MMP1 and FHL1 are potentially functional proteins associated with differences of highly-metastatic prostate cancer PC-3M-1E8 cell line and poorly-metastatic PC-3M-2B4 cell line.

  2. FHL1 can either suppress or promote tumor cell growth depending on the status of the sites for phosphorylation by Src.

  3. FHL1 increase inhibitory CDC25 phosphorylation by forming a complex with CHK2 and CDC25, and sequester CDC25 in the cytoplasm by forming another complex with 14-3-3 and CDC25, resulting in increased radioresistance in cancer cells.

  4. FHL1 promote paclitaxel resistance in hepatocellular carcinomas cells through regulating apoptosis induced by paclitaxel, suggesting that FHL1 may be a promising molecular target for Hepatocellular carcinoma therapy.

  5. Altogether, the specific localization of FHL1B and its modulation in disease-patient's myoblasts confirmed FHL1-related Emery-Dreifuss muscular dystrophy as a nuclear envelope disease.

  6. Low FHL1 expression is associated with head and neck squamous cell carcinoma.

  7. We have uncovered FHL1 as a novel potential regulator of calcium homeostasis in both fish and humans and have implicated it in isolated hypoparathyroidism.

  8. Mutations in FHL1 cause unclassifiable cardiomyopathy with coexisting Emery-Dreifuss muscular dystrophy.

  9. results provide evidence that FHL1A interacts with PLEKHG2 and regulates cell morphological change through the activity of PLEKHG2.

  10. a novel FHL1 splice site variant results in the absence of FHL1A and the abundance of FHL1C, which may contribute to the complex and severe phenotype of Uruguay syndrome.

  11. Knockdown of FHL1 with FHL1 small interfering RNA (siRNA) promoted tumor growth and Cyclin D and cyclin E were markedly elevated at both the protein and mRNA level.

  12. results indicate that anti-FHL1 autoantibodies in peripheral blood have promising potential as a biomarker to identify a subset of severe IIM.

  13. In healthy individuals, FHL1A is the predominant splice variant and is mainly found in skeletal and cardiac muscle. In two individuals with an Emery-Dreifuss plus phenotype with pulmonary artery hypoplasia and facial dysmorphology, there was demonstrated loss of isoform A and B, and an almost 200-fold overexpression of isoform C.

  14. FRG1 mice overexpressing FHL1 showed an improvement in the dystrophic phenotype

  15. FHL1 shRNA could significantly accelerate tumor cell growth via inhibiting the expression of FHL1

  16. Our results suggest that miR-410 may function as an oncomiR and are consistent with its key function in regulating FHL1 in certain digestive system cancers.

  17. These data suggested that up-regulated FHL1 in smooth muscle in HSCR might be associated with intestinal wall remodeling in HSCR and might be one of the risk factors for gastrointestinal motor dysfunction

  18. This is the first study to show that FHL1 mutations identified in several clinically distinct myopathies lead to similar protein aggregation and impair myotube formation.

  19. The study has revealed that FHL1C overexpression induces Jurkat cell apoptosis.

  20. FHL-1 is the predominant complement regulator in Bruch's membrane having direct implications for age-related macular degeneration.

Mouse (Murine) Four and A Half LIM Domains 1 (FHL1) interaction partners

  1. mutant mice harboring the missense mutation p.W122S in Fhl1 gene developed late-onset cardiac dysfunction without skeletal myopathy

  2. KyoT2 downregulates airway remodeling and resistance in asthmatic mice through a Hes1-dependent mechanism.

  3. Results found that osteogenesis increases with the overexpression of Fhl1 and decreases with reduced Fhl1 expression and suggest that Fhl1 mediates interacting estrogen and Wnt signaling during osteogenesis.

  4. Findings indicate that loss of function is responsible for the myopathy in the Fhl1 W122S knock-in mice.

  5. The CSL-KyoT2 corepressor complex is a negative regulator of Notch signaling.

  6. Data show that loss of FHL1 function leads to myopathy in vivo and suggest that loss of function of FHL1 may be one of the mechanisms underlying muscle dystrophy in patients with FHL1 mutations.

  7. Fhl1 transcriptional changes provide salutary effects on stressed myocytes in cardiomyopathy.

  8. Data suggest Fhl1 (four-and-a-half LIM domains protein 1) and FHL2 (four-and-a-half LIM domains protein 2) bind to and regulate activity of Prkd1 (protein kinase D 1) in cardiac/ventricular myocytes; knockdown of Fhl1 down-regulates Prkd1 activation.

  9. A novel mechanism involving four-and-a-half LIM domain protein-1 and extracellular signal-regulated kinase-2 regulates titin phosphorylation and mechanics.

  10. Wnt signaling induces muscle cell differentiation, at least partly, through Fhl1 activation.

  11. FHL1 is a novel regulator of myosin-binding protein C activity that may have a role in sarcomere assembly

  12. These results suggest that KyoT2 is a substrate of SUMO modification catalyzed by PIAS1, and that SUMOylation may modulate the transcriptional repression effect of KyoT2 on the Notch/RBP-J signaling pathway.

  13. significantly altered expression after short-term hypoxic exposure; identified as a novel protein regulated in various forms of pulmonary hypertension

  14. KyoT3 is an isoform of murine FHL1, which associates with the transcription factor RBP-J and represses the RBP-J-mediated transactivation

  15. four-and-a-half LIM domains 1 (FHL1) is part of a complex within the cardiomyocyte sarcomere that senses the biomechanical stress-induced responses important for cardiac hypertrophy.

  16. FHL1 appears to modulate muscle mass and strength enhancement.

  17. Data show that SLIMMER delayed Siva-1-dependent apoptosis in C2C12 myoblasts.

Pig (Porcine) Four and A Half LIM Domains 1 (FHL1) interaction partners

  1. The LIM domain protein FHL1C interacts with tight junction protein ZO-1 contributing to the epithelial-mesenchymal transition of a breast adenocarcinoma cell line.

Four and A Half LIM Domains 1 (FHL1) Antigen Profile

Protein Summary

This gene encodes a member of the four-and-a-half-LIM-only protein family. Family members contain two highly conserved, tandemly arranged, zinc finger domains with four highly conserved cysteines binding a zinc atom in each zinc finger. Expression of these family members occurs in a cell- and tissue-specific mode and these proteins are involved in many cellular processes. Mutations in this gene have been found in patients with Emery-Dreifuss muscular dystrophy. Multiple alternately spliced transcript variants which encode different protein isoforms have been described.

Gene names and symbols associated with FHL1

  • four and a half LIM domains 1 (fhl1) antibody
  • four and a half LIM domains 1 (FHL1) antibody
  • four and a half LIM domains 1a (fhl1a) antibody
  • Four and a half LIM domains protein 1 (fhl1) antibody
  • four and a half LIM domains 1 S homeolog (fhl1.S) antibody
  • four and a half LIM domains 1 (Fhl1) antibody
  • DKFZp468O1927 antibody
  • fhl antibody
  • FHL-1 antibody
  • Fhl1 antibody
  • FHL1A antibody
  • FHL1B antibody
  • fhla antibody
  • FLH1A antibody
  • KyoT antibody
  • MGC89165 antibody
  • SLIM antibody
  • SLIM-1 antibody
  • SLIM1 antibody
  • SLIMMER antibody
  • XMPMA antibody
  • zgc:92025 antibody

Protein level used designations for FHL1

four and a half LIM domains 1 , four and a half LIM domains protein 1-like , four and a half LIM domains a , four and a half LIM domains protein 1 , Four and a half LIM domains protein 1 , four and a half lim domains protein 1 , LIM protein SLIMMER , four-and-a-half Lin11, Isl-1 and Mec-3 domains 1 , skeletal muscle LIM-protein 1 , FHL-1 , RAM14-1 , RBP-associated molecule 14-1 , SLIM , SLIM-1 , four and a half LIM domains 1 protein

448334 Xenopus (Silurana) tropicalis
710692 Macaca mulatta
100172515 Pongo abelii
100307044 Ovis aries
100357263 Oryctolagus cuniculus
100387250 Callithrix jacchus
100590327 Nomascus leucogenys
399646 Danio rerio
100196873 Salmo salar
100529032 Ictalurus punctatus
447182 Xenopus laevis
2273 Homo sapiens
14199 Mus musculus
25177 Rattus norvegicus
509056 Bos taurus
397667 Sus scrofa
492162 Canis lupus familiaris
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