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The protein encoded by FHL3 is a member of a family of proteins containing a four-and-a-half LIM domain, which is a highly conserved double zinc finger motif. Additionally we are shipping Four and A Half LIM Domains 3 Proteins (7) and many more products for this protein.
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the present study established a link between Ang (show ANG Antibodies) and FHL3 proteins and identifies a new pathway for regulating astrocytoma progression.
These findings suggest that functional interactions between FHL3 and MT-1X (show MT1X Antibodies) may provide some clues to the mechanisms of FHL3-regulated cell proliferation.
PCBP2 (show PCBP2 Antibodies) could bind to FHL3 mRNA 3'UTR (show UTS2R Antibodies)-A and inhibited the expression of FHL3 in T98G glioms cells
FHL3 enhances Tax1 (show CNTN2 Antibodies)-mediated activation of the Human T-cell leukemia virus type 1 long terminal repeat (LTR) without affecting basal activity and regulates NF-kappaB (show NFKB1 Antibodies) activation by Tax1 (show CNTN2 Antibodies) in a cell-specific manner.
findings suggest that the interaction between Ang (show ANG Antibodies) and FHL3 may provide some clues to the mechanisms of Ang (show ANG Antibodies)-regulated cell growth and apoptosis
FHL3 suppressed anchorage-dependent and -independent growth of human breast cancer cells.
FHL3 does not bind to HIF-1alpha (show HIF1A Antibodies) or p300 (show EP300 Antibodies), indicating that it regulates transactivation by a novel molecular mechanism.
the second zinc finger motif in LIM4 was responsible for the auto-activation of FHL3.
Data show that FHL3 (human four-and-a-half LIM-only protein 3 (show LMO3 Antibodies)) interacts with human phosphatase CDC25B (show CDC25B Antibodies) in the cell nucleus.
FHL2 (show FHL2 Antibodies) and FHL3, respectively, are colocalized with alpha(7)beta(1) integrin receptor at the periphery of Z-discs, suggesting a role in mechanical stabilization of muscle cells
Four and a half LIM domain protein (show PDLIM7 Antibodies) 3 (show HSPB3 Antibodies) could interact with MyoD (show MYOD1 Antibodies), cyclic AMP (show TMPRSS5 Antibodies)-responsive elements and phosphorylated cAMP response element binding protein in vivo
Actin was identified as a FHL3 binding partner; FHL3 is a significant regulator of actin cytoskeletal dynamics in skeletal myoblasts.
These studies demonstrate that Sox15 (show SOX15 Antibodies), Fhl3 and Foxk1 (show Foxk1 Antibodies) function to coordinately regulate the myogenic progenitor cell population and skeletal muscle regeneration.
The protein encoded by this gene is a member of a family of proteins containing a four-and-a-half LIM domain, which is a highly conserved double zinc finger motif. The encoded protein has been shown to interact with the cancer developmental regulators SMAD2, SMAD3, and SMAD4, the skeletal muscle myogenesis protein MyoD, and the high-affinity IgE beta chain regulator MZF-1. This protein may be involved in tumor suppression, repression of MyoD expression, and repression of IgE receptor expression. Two transcript variants encoding different isoforms have been found for this gene.
four and a half LIM domains 3
, four and a half LIM domains protein 3
, LIM-only protein FHL3
, skeletal muscle LIM-protein 2