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The protein encoded by FHL3 is a member of a family of proteins containing a four-and-a-half LIM domain, which is a highly conserved double zinc finger motif. Additionally we are shipping Four and A Half LIM Domains 3 Proteins (8) and and many more products for this protein.
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the present study established a link between Ang and FHL3 proteins and identifies a new pathway for regulating astrocytoma progression.
These findings suggest that functional interactions between FHL3 and MT-1X may provide some clues to the mechanisms of FHL3-regulated cell proliferation.
PCBP2 could bind to FHL3 mRNA 3'UTR-A and inhibited the expression of FHL3 in T98G glioms cells
FHL3 enhances Tax1-mediated activation of the Human T-cell leukemia virus type 1 long terminal repeat (LTR) without affecting basal activity and regulates NF-kappaB activation by Tax1 in a cell-specific manner.
findings suggest that the interaction between Ang and FHL3 may provide some clues to the mechanisms of Ang-regulated cell growth and apoptosis
FHL3 suppressed anchorage-dependent and -independent growth of human breast cancer cells.
FHL3 does not bind to HIF-1alpha or p300, indicating that it regulates transactivation by a novel molecular mechanism.
the second zinc finger motif in LIM4 was responsible for the auto-activation of FHL3.
Data show that FHL3 (human four-and-a-half LIM-only protein 3) interacts with human phosphatase CDC25B in the cell nucleus.
FHL2 and FHL3, respectively, are colocalized with alpha(7)beta(1) integrin receptor at the periphery of Z-discs, suggesting a role in mechanical stabilization of muscle cells
MZF-1 and FHL3 formed a complex of high molecular mass with some additional proteins in the nucleus. Transcriptional repression of FcepsilonRI by MZF-1 required FHL3.
FHL3 association with MyoD may contribute to the regulation of MyoD-dependent transcription of muscle genes and thereby myogenesis
Human four-and-a-half LIM family members suppress tumor cell growth through a TGF-beta-like signaling pathway.
Four and a half LIM domain protein 3 could interact with MyoD, cyclic AMP-responsive elements and phosphorylated cAMP response element binding protein in vivo
Actin was identified as a FHL3 binding partner; FHL3 is a significant regulator of actin cytoskeletal dynamics in skeletal myoblasts.
These studies demonstrate that Sox15, Fhl3 and Foxk1 function to coordinately regulate the myogenic progenitor cell population and skeletal muscle regeneration.
The protein encoded by this gene is a member of a family of proteins containing a four-and-a-half LIM domain, which is a highly conserved double zinc finger motif. The encoded protein has been shown to interact with the cancer developmental regulators SMAD2, SMAD3, and SMAD4, the skeletal muscle myogenesis protein MyoD, and the high-affinity IgE beta chain regulator MZF-1. This protein may be involved in tumor suppression, repression of MyoD expression, and repression of IgE receptor expression. Two transcript variants encoding different isoforms have been found for this gene.
four and a half LIM domains 3
, four and a half LIM domains protein 3
, LIM-only protein FHL3
, skeletal muscle LIM-protein 2