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The protein encoded by FXR2 is a RNA binding protein containing two KH domains and one RCG box, which is similar to FMRP and FXR1.
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Human Monoclonal FXR2 Primary Antibody for ICC, IF - ABIN152598
Darnell, Fraser, Mostovetsky, Darnell: Discrimination of common and unique RNA-binding activities among Fragile X mental retardation protein paralogs. in Human molecular genetics 2009
Cow (Bovine) Polyclonal FXR2 Primary Antibody for WB - ABIN2778916
Ewing, Chu, Elisma, Li, Taylor, Climie, McBroom-Cerajewski, Robinson, OConnor, Li, Taylor, Dharsee, Ho, Heilbut, Moore, Zhang, Ornatsky, Bukhman, Ethier, Sheng, Vasilescu, Abu-Farha, Lambert, Duewel et al.: Large-scale mapping of human protein-protein interactions by mass spectrometry. ... in Molecular systems biology 2007
Human Monoclonal FXR2 Primary Antibody for ICC, IF - ABIN108611
Zhang, OConnor, Siomi, Srinivasan, Dutra, Nussbaum, Dreyfuss: The fragile X mental retardation syndrome protein interacts with novel homologs FXR1 and FXR2. in The EMBO journal 1996
Inhibition of the remaining family member FXR1 (show FXR1 Antibodies) selectively blocks cell proliferation in human cancer cells containing homozygous deletion of both TP53 (show TP53 Antibodies) and FXR2 in a collateral lethality manner.
An accumulation of 8 SNPs in the fragile gene family (FMR1 (show FMR1 Antibodies), FXR1 (show FXR1 Antibodies) and FXR2)were found associated with autistic traits in a sample of male patients.
Data show that the nuclear localization signals of the FXR1 (show FXR1 Antibodies) and FXR2 comprise tandem Tudor domain architectures.
These results indicate that FMR1 (show FMR1 Antibodies) gene function is evolutionarily conserved in neural mechanisms and cannot be compensated by either FXR1 (show FXR1 Antibodies) or FXR2, but that all three proteins can substitute for each other in non-neuronal requirements.
FXR1P (show FXR1 Antibodies) and FXR2P KH2 (show KCNG1 Antibodies) domains bind G-quadruplex and kissing complex RNA with the same affinity as the FMRP (show FMR1 Antibodies) KH2 (show KCNG1 Antibodies) domain.
We discovered that FXR1P (show FXR1 Antibodies)-deficient aNSCs have altered expression of a select number of cell-cycle genes, and we identified the mRNA of cyclin-dependent kinase inhibitor 1A (Cdkn1a (show CDKN1A Antibodies), p21 (show D4S234E Antibodies)) as a direct target of FXR1P (show FXR1 Antibodies).
Both Fmr1 (show FMR1 Antibodies) and Fxr2 knockout mice have reduced fat deposits and glucose metabolism.
these findings show a coordinated regulation of PSD95/Dlg4 (show DLG4 Antibodies) mRNA by FMRP (show FMR1 Antibodies) and FXR2P that ultimately affects its fine-tuning during synaptic activity.
Differential regulation of SVZ and DG stem cells by FXR2 may be a key component of the mechanism that governs the different neurogenic processes in these two adult germinal.
Findings suggest that Fmr1 (show FMR1 Antibodies) and Fxr2 genes contribute in a cooperative manner to pathways controlling locomotor activity, sensorimotor gating and cognitive processes.
Fxr2 regulates mammalian circadian behavioral rhythms.
to unravel the function of Fxr2 protein, the expression pattern of 12,588 genes was studied in the brains of wild-type and Fxr2 knockout mice; genes and gene groups de-regulated in the brains of Fxr2 knockout mice were identified
The protein encoded by this gene is a RNA binding protein containing two KH domains and one RCG box, which is similar to FMRP and FXR1. It associates with polyribosomes, predominantly with 60S large ribosomal subunits. This encoded protein may self-associate or interact with FMRP and FXR1. It may have a role in the development of fragile X mental retardation syndrome.
fragile X mental retardation syndrome-related protein 2
, fragile X mental retardation syndrome related protein 2
, fragile X mental retardation, autosomal homolog 2
, fragile X mental retardation syndrome-related protein 2-like
, fragile X-mental retardation 1-like 2
, fragile X mental retardation gene 2, autosomal homolog
, fragile X mental retardation-related protein 2