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anti-Fragile X Mental Retardation, Autosomal Homolog 2 (FXR2) Antibodies

The protein encoded by FXR2 is a RNA binding protein containing two KH domains and one RCG box, which is similar to FMRP and FXR1. Additionally we are shipping Fragile X Mental Retardation, Autosomal Homolog 2 Proteins (3) and and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
FXR2 9513 P51116
FXR2 23879  
FXR2 287433  
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Top anti-Fragile X Mental Retardation, Autosomal Homolog 2 Antibodies at antibodies-online.com

Showing 10 out of 73 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Delivery Price Details
Cow Rabbit Un-conjugated WB WB Suggested Anti-FXR2 Antibody Titration: 0.2-1 ug/ml Positive Control: MCF7 cell lysate FXR2 is supported by BioGPS gene expression data to be expressed in MCF7 100 μL 2 to 3 Days
$289.00
Details
Human Rabbit Un-conjugated IC, IF, IHC, WB Immunofluorescent analysis of FXR2 staining in HepG2 cells. Formalin-fixed cells were permeabilized with 0.1% Triton X-100 in TBS for 5-10 minutes and blocked with 3% BSA-PBS for 30 minutes at room temperature. Cells were probed with the primary antibody in 3% BSA-PBS and incubated overnight at 4 °C in a humidified chamber. Cells were washed with PBST and incubated with a DyLight 594-conjugated secondary antibody (red) in PBS at room temperature in the dark. DAPI was used to stain the cell nuclei (blue). Immunohistochemical analysis of FXR2 staining in human brain formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with the antibody at room temperature and detected using an HRP conjugated compact polymer system. DAB was used as the chromogen. The section was then counterstained with haematoxylin and mounted with DPX. 200 μL 13 to 14 Days
$487.50
Details
Human Rabbit Un-conjugated IF, IHC, ELISA, WB Western blot analysis of extracts from COLO205 cells, using FXR2 Antibody. The lane on the right is treated with the synthesized peptide. Immunohistochemistry analysis of paraffin-embedded human lung carcinoma tissue, using FXR2 Antibody. The picture on the right is treated with the synthesized peptide. 100 μg 2 to 3 Days
$302.50
Details
Human Mouse Un-conjugated IHC, IHC (p), WB Human Brain, Cerebellum (formalin-fixed, paraffin-embedded) stained with FXR2 antibody ABIN214244 at 10 ug/ml followed by biotinylated anti-mouse IgG secondary antibody ABIN481714, alkaline phosphatase-streptavidin and chromogen. Anti-FXR2 antibody IHC of human brain, cerebellum. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 10 ug/ml. 50 μL 11 to 14 Days
$484.00
Details
Cow Rabbit Un-conjugated WB 100 μL 11 to 14 Days
$551.83
Details
Human Rabbit Un-conjugated ELISA, ICC, IF, IHC, WB ABIN6274272 at 1/100 staining Mouse heart tissue by IHC-P. The sample was formaldehyde fixed and a heat mediated antigen retrieval step in citrate buffer was performed. The sample was then blocked and incubated with the antibody for 1.5 hours at 22°C. An HRP conjugated goat anti-rabbit antibody was used as the secondary. Western blot analysis of extracts from COLO205 cells, using FXR2 antibody.The lane on the left is treated with the antigen-specific peptide. 100 μL 11 to 12 Days
$390.77
Details
Human Rabbit Un-conjugated IF, IP, WB Western blot analysis of extracts of various cell lines, using FXR2 antibody (ABIN1872752) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 90s. 100 μL 11 to 13 Days
$366.77
Details
Human Rabbit Un-conjugated ELISA, IF, IHC, IHC (p), WB 100 μL 11 to 14 Days
$493.17
Details
Human Mouse Un-conjugated IHC (p), WB 50 μL 11 to 13 Days
$768.40
Details
Human Rabbit Un-conjugated ELISA, IF, IHC, WB   100 μL Available
$363.46
Details

Top referenced anti-Fragile X Mental Retardation, Autosomal Homolog 2 Antibodies

  1. Cow (Bovine) Polyclonal FXR2 Primary Antibody for WB - ABIN2778916 : Ewing, Chu, Elisma, Li, Taylor, Climie, McBroom-Cerajewski, Robinson, OConnor, Li, Taylor, Dharsee, Ho, Heilbut, Moore, Zhang, Ornatsky, Bukhman, Ethier, Sheng, Vasilescu, Abu-Farha, Lambert, Duewel et al.: Large-scale mapping of human protein-protein interactions by mass spectrometry. ... in Molecular systems biology 2007 (PubMed)

  2. Human Monoclonal FXR2 Primary Antibody for ICC, IF - ABIN152598 : Darnell, Fraser, Mostovetsky, Darnell: Discrimination of common and unique RNA-binding activities among Fragile X mental retardation protein paralogs. in Human molecular genetics 2009 (PubMed)

  3. Human Monoclonal FXR2 Primary Antibody for ICC, IF - ABIN108611 : Zhang, OConnor, Siomi, Srinivasan, Dutra, Nussbaum, Dreyfuss: The fragile X mental retardation syndrome protein interacts with novel homologs FXR1 and FXR2. in The EMBO journal 1996 (PubMed)

More Antibodies against Fragile X Mental Retardation, Autosomal Homolog 2 Interaction Partners

Human Fragile X Mental Retardation, Autosomal Homolog 2 (FXR2) interaction partners

  1. Inhibition of the remaining family member FXR1 selectively blocks cell proliferation in human cancer cells containing homozygous deletion of both TP53 and FXR2 in a collateral lethality manner.

  2. An accumulation of 8 SNPs in the fragile gene family (FMR1, FXR1 and FXR2)were found associated with autistic traits in a sample of male patients.

  3. Data show that the nuclear localization signals of the FXR1 and FXR2 comprise tandem Tudor domain architectures.

  4. These results indicate that FMR1 gene function is evolutionarily conserved in neural mechanisms and cannot be compensated by either FXR1 or FXR2, but that all three proteins can substitute for each other in non-neuronal requirements.

  5. FXR1P and FXR2P KH2 domains bind G-quadruplex and kissing complex RNA with the same affinity as the FMRP KH2 domain.

Mouse (Murine) Fragile X Mental Retardation, Autosomal Homolog 2 (FXR2) interaction partners

  1. We discovered that FXR1P-deficient aNSCs have altered expression of a select number of cell-cycle genes, and we identified the mRNA of cyclin-dependent kinase inhibitor 1A (Cdkn1a, p21) as a direct target of FXR1P.

  2. Both Fmr1 and Fxr2 knockout mice have reduced fat deposits and glucose metabolism.

  3. these findings show a coordinated regulation of PSD95/Dlg4 mRNA by FMRP and FXR2P that ultimately affects its fine-tuning during synaptic activity.

  4. Differential regulation of SVZ and DG stem cells by FXR2 may be a key component of the mechanism that governs the different neurogenic processes in these two adult germinal.

  5. This protein shows high expression in brain and testis. The protein was tested in a behavioral test battery in knockout mice. The mice showed behavioral abnormalities.

  6. Findings suggest that Fmr1 and Fxr2 genes contribute in a cooperative manner to pathways controlling locomotor activity, sensorimotor gating and cognitive processes.

  7. Fxr2 regulates mammalian circadian behavioral rhythms.

  8. to unravel the function of Fxr2 protein, the expression pattern of 12,588 genes was studied in the brains of wild-type and Fxr2 knockout mice; genes and gene groups de-regulated in the brains of Fxr2 knockout mice were identified

  9. FXR1P and FXR2P KH2 domains bind G-quadruplex and kissing complex RNA with the same affinity as the FMRP KH2 domain.

Fragile X Mental Retardation, Autosomal Homolog 2 (FXR2) Antigen Profile

Protein Summary

The protein encoded by this gene is a RNA binding protein containing two KH domains and one RCG box, which is similar to FMRP and FXR1. It associates with polyribosomes, predominantly with 60S large ribosomal subunits. This encoded protein may self-associate or interact with FMRP and FXR1. It may have a role in the development of fragile X mental retardation syndrome.

Gene names and symbols associated with FXR2

  • FMR1 autosomal homolog 2 (FXR2) antibody
  • fragile X mental retardation, autosomal homolog 2 (fxr2) antibody
  • fragile X mental retardation, autosomal homolog 2 (Fxr2) antibody
  • FMR1 autosomal homolog 2 (Fxr2) antibody
  • FMR1L2 antibody
  • Fxr2h antibody
  • FXR2P antibody
  • id:ibd5046 antibody
  • zgc:56215 antibody
  • zgc:77472 antibody

Protein level used designations for FXR2

fragile X mental retardation syndrome-related protein 2 , fragile X mental retardation syndrome related protein 2 , fragile X mental retardation, autosomal homolog 2 , fragile X mental retardation syndrome-related protein 2-like , fragile X-mental retardation 1-like 2 , fragile X mental retardation gene 2, autosomal homolog , fragile X mental retardation-related protein 2

GENE ID SPECIES
100512131 Sus scrofa
393180 Danio rerio
721889 Macaca mulatta
749002 Pan troglodytes
100343838 Oryctolagus cuniculus
100387469 Callithrix jacchus
9513 Homo sapiens
23879 Mus musculus
489478 Canis lupus familiaris
618127 Bos taurus
287433 Rattus norvegicus
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