anti-Frequently Rearranged in Advanced T-Cell Lymphomas (FRAT1) Antibodies

The protein encoded by FRAT1 belongs to the GSK-3-binding protein family. Additionally we are shipping FRAT1 Kits (4) and FRAT1 Proteins (4) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
FRAT1 14296 P70339
FRAT1 10023 Q92837
FRAT1    
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Top anti-FRAT1 Antibodies at antibodies-online.com

Showing 10 out of 39 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Delivery Price Details
Human Rabbit Un-conjugated EIA, IHC (p), WB 0.4 mL 6 to 8 Days
$484.00
Details
Human Rabbit Un-conjugated EIA, IHC (p), WB 0.4 mL 6 to 8 Days
$484.00
Details
Human Rabbit Un-conjugated ELISA, WB Western blot analysis FRAT1 using Jurkat whole cell lysates 100 μL 11 to 12 Days
$390.77
Details
Human Rabbit Un-conjugated IHC (p), WB Western blot analysis of FRAT1 using rabbit polyclonal FRAT1 Antibody.293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected with the FRAT1 gene (Lane 2). Formalin-fixed and paraffin-embedded human lung carcinoma tissue reacted with FRAT1 antibody , which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. 400 μL 2 to 3 Days
$515.63
Details
Human Rabbit Un-conjugated IHC (p), WB Western blot analysis of lysates from SK-BR-3, K562 cell line (from left to right), using FRAT1 Antibody at 1:1000 at each lane. Formalin-fixed and paraffin-embedded human lung carcinoma tissue reacted with FRAT1 antibody , which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. 400 μL 2 to 3 Days
$515.63
Details
Human Rabbit Un-conjugated ELISA, WB   100 μL 11 to 13 Days
$335.04
Details
Human Mouse Un-conjugated ELISA, WB Detection limit for recombinant GST tagged FRAT1 is 0.1 ng/ml as a capture antibody. Western Blot detection against Immunogen (36.63 KDa) . 100 μg 11 to 12 Days
$440.00
Details
Human Rabbit Un-conjugated IHC, ELISA, WB   200 μL 11 to 16 Days
$658.43
Details
Human Rabbit Un-conjugated IHC, ELISA, WB   200 μL 11 to 16 Days
$658.43
Details
Human Rabbit FITC IF (p)   100 μL 14 to 21 Days
$416.90
Details

Top referenced anti-FRAT1 Antibodies

  1. Human Polyclonal FRAT1 Primary Antibody for IHC (p), ELISA - ABIN544043 : Wang, Hewitt, Liu, Zhou, Zhu, Zhou, Zhang, Quan, Bai, Xu: Tissue microarray analysis of human FRAT1 expression and its correlation with the subcellular localisation of beta-catenin in ovarian tumours. in British journal of cancer 2006 (PubMed)
    Show all 3 Pubmed References

  2. Human Polyclonal FRAT1 Primary Antibody for IHC (fro), ELISA - ABIN544044 : Hino, Michiue, Asashima, Kikuchi: Casein kinase I epsilon enhances the binding of Dvl-1 to Frat-1 and is essential for Wnt-3a-induced accumulation of beta-catenin. in The Journal of biological chemistry 2003 (PubMed)
    Show all 3 Pubmed References

More Antibodies against FRAT1 Interaction Partners

Mouse (Murine) Frequently Rearranged in Advanced T-Cell Lymphomas (FRAT1) interaction partners

  1. Gsk3b is exported from the nucleus in a complex with Frat. Loss of PI3K/Akt activity results in dissociation of this complex and retention of Gsk3b in the nucleus.

  2. Data show that that Frat synergizes with Diversin in the activation of JNK/AP-1 signaling.

  3. FRAT has a role in mediating GSK-3 nuclear export in mouse cells

  4. Data suggest that recruitment of Axin and Frat1 to the membrane by LRP5-triggered Wnt3 signaling leads to both Axin degradation and Frat1-mediated inhibition of glycogen synthase kinase-3.

Human Frequently Rearranged in Advanced T-Cell Lymphomas (FRAT1) interaction partners

  1. The results of the present study suggest that nuclear FRAT1 activates the Wnt/beta-catenin signaling pathway and confers an increase in prostate cancer cell growth.

  2. These data suggest a potential role for targeting FRAT1 in the prevention of hypoxia-induced HCC cancer progression and metastasis mediated by epithelial-to-mesenchymal transition

  3. FRAT1 and ABCG2 overexpression is associated with carcinogenesis, progression, and poor prognosis in patients with Pancreatic ductal adenocarcinoma.

  4. Positive ROR2 and FRAT1 expression is associated with the progression and poor prognosis of chondrosarcoma.

  5. FRAT1 overexpression correlates with pathologic grade, proliferation, invasion and angiogenesis in brain gliomas.

  6. The mechanism of inhibiting beta-catenin phosphorylation involves the NDRG1-mediated upregulation of the GSK3beta-binding protein FRAT1.

  7. These results highlight the potential role of FRAT1 in tumorigenesis and progression of glioblastoma.

  8. The overexpression of Frat1 and beta-catenin was correlated with tumor differentiation, TNM stage, lymph node metastasis, and poor prognosis of NSCLC.

  9. Down-regulation of Frat1 expression reduced invasive ability in A549 cell line, further supporting idea that Frat1 may play crucial role in carcinogenesis, tumor invasiveness and dissemination in human lung cancer.

  10. Elevated expression of FRAT1 was associated with astrocytomas.

  11. Our results suggest that FRAT1 may be an important factor in the tumorigenesis and progression of gliomas, and could be used as a potential molecular marker for pathological diagnosis and a target for biological therapy.

  12. CKI epsilon-dependent phosphorylation of Dvl enhances the formation of a complex of Dvl-1 with Frat-1 and this complex leads to the activation of Wnt-3a-induced accumulation of beta-catenin

  13. findings support that Wnt/beta-catenin signalling may be aberrantly activated through FRAT1 overexpression in ovarian serous adenocarcinomas

  14. PKA phosphorylates FRAT1 in vitro as well as in intact cells and may play a role in regulating the inhibitory activity of FRAT1 toward GSK-3.

  15. Aberrant activation of beta-catenin/TCF pathway in esophageal cancer appears to be due to upstream events such as FRAT1 overexpression, and c-Myc may be an important element in oncogenesis of human ESCC induced by FRAT1.

FRAT1 Antigen Profile

Protein Summary

The protein encoded by this gene belongs to the GSK-3-binding protein family. The protein inhibits GSK-3-mediated phosphorylation of beta-catenin and positively regulates the Wnt signaling pathway. It may function in tumor progression and in lymphomagenesis.

Gene names and symbols associated with FRAT1

  • FRAT1, WNT signaling pathway regulator (FRAT1) antibody
  • GSK-3 binding protein FRAT1 (frat1) antibody
  • frequently rearranged in advanced T cell lymphomas (Frat1) antibody
  • frequently rearranged in advanced T-cell lymphomas (FRAT1) antibody
  • frequently rearranged in advanced T-cell lymphomas 1 S homeolog (frat1.S) antibody
  • AW060382 antibody
  • frat1 antibody
  • gbp antibody

Protein level used designations for FRAT1

GSK-3 binding protein FRAT1 , frequently rearranged in advanced T-cell lymphomas , gsk3-binding protein , FRAT-1 , frequently rearranged in advanced T-cell lymphomas 1 , proto-oncogene FRAT1 , GSK-3 binding protein GBP , GSK-3-binding protein , gsk binding protein

GENE ID SPECIES
466169 Pan troglodytes
705609 Macaca mulatta
100303596 Saccoglossus kowalevskii
14296 Mus musculus
10023 Homo sapiens
486819 Canis lupus familiaris
398043 Xenopus laevis
505664 Bos taurus
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