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The protein encoded by FRAT1 belongs to the GSK-3-binding protein family. Additionally we are shipping FRAT1 Proteins (4) and FRAT1 Kits (2) and many more products for this protein.
Showing 10 out of 33 products:
Human Polyclonal FRAT1 Primary Antibody for IHC (p), WB - ABIN388208
Hagen, Cross, Culbert, West, Frame, Morrice, Reith: FRAT1, a substrate-specific regulator of glycogen synthase kinase-3 activity, is a cellular substrate of protein kinase A. in The Journal of biological chemistry 2006
Show all 4 Pubmed References
Gsk3b (show GSK3b Antibodies) is exported from the nucleus in a complex with Frat. Loss of PI3K/Akt (show AKT1 Antibodies) activity results in dissociation of this complex and retention of Gsk3b (show GSK3b Antibodies) in the nucleus.
Data show that that Frat synergizes with Diversin (show ANKRD6 Antibodies) in the activation of JNK (show MAPK8 Antibodies)/AP-1 (show JUN Antibodies) signaling.
FRAT has a role in mediating GSK-3 (show GSK3b Antibodies) nuclear export in mouse cells
Data suggest that recruitment of Axin (show AXIN1 Antibodies) and Frat1 to the membrane by LRP5 (show LRP5 Antibodies)-triggered Wnt3 (show WNT3 Antibodies) signaling leads to both Axin (show AXIN1 Antibodies) degradation and Frat1-mediated inhibition of glycogen synthase kinase-3 (show GSK3a Antibodies).
The results of the present study suggest that nuclear FRAT1 activates the Wnt (show WNT2 Antibodies)/beta-catenin (show CTNNB1 Antibodies) signaling pathway and confers an increase in prostate cancer cell growth.
These data suggest a potential role for targeting FRAT1 in the prevention of hypoxia-induced HCC (show FAM126A Antibodies) cancer progression and metastasis mediated by epithelial-to-mesenchymal transition
FRAT1 and ABCG2 (show ABCG2 Antibodies) overexpression is associated with carcinogenesis, progression, and poor prognosis in patients with Pancreatic ductal adenocarcinoma.
Positive ROR2 (show ROR2 Antibodies) and FRAT1 expression is associated with the progression and poor prognosis of chondrosarcoma.
FRAT1 overexpression correlates with pathologic grade, proliferation, invasion and angiogenesis in brain gliomas.
The mechanism of inhibiting beta-catenin (show CTNNB1 Antibodies) phosphorylation involves the NDRG1 (show NDRG1 Antibodies)-mediated upregulation of the GSK3beta (show GSK3b Antibodies)-binding protein FRAT1.
These results highlight the potential role of FRAT1 in tumorigenesis and progression of glioblastoma.
The overexpression of Frat1 and beta-catenin (show CTNNB1 Antibodies) was correlated with tumor differentiation, TNM (show ODZ1 Antibodies) stage, lymph node metastasis, and poor prognosis of NSCLC.
Down-regulation of Frat1 expression reduced invasive ability in A549 cell line, further supporting idea that Frat1 may play crucial role in carcinogenesis, tumor invasiveness and dissemination in human lung cancer.
Elevated expression of FRAT1 was associated with astrocytomas.
The protein encoded by this gene belongs to the GSK-3-binding protein family. The protein inhibits GSK-3-mediated phosphorylation of beta-catenin and positively regulates the Wnt signaling pathway. It may function in tumor progression and in lymphomagenesis.
GSK-3 binding protein FRAT1
, frequently rearranged in advanced T-cell lymphomas
, gsk3-binding protein
, frequently rearranged in advanced T-cell lymphomas 1
, proto-oncogene FRAT1
, GSK-3 binding protein GBP
, GSK-3-binding protein
, gsk binding protein