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FLI1 encodes a transcription factor containing an ETS DNA-binding domain. Additionally we are shipping Friend Leukemia Virus Integration 1 Antibodies (159) and Friend Leukemia Virus Integration 1 Kits (5) and many more products for this protein.
Showing 7 out of 7 products:
miR (show MLXIP Proteins)-145 acts as a tumor suppressor by directly reducing expression of FLI-1, and the miR (show MLXIP Proteins)-145/FLI-1 pathway is important for tumor progression in osteosarcoma
this paper provides a mechanistic insight into the regulation of angiogenesis by TLRs and confirm a central role of Fli1 in regulating vascular homeostasis.
Recent advances in biologic and genomic understanding of these two cancers has expanded the potential for therapeutic advancement and prevention. In Ewing sarcoma, directed focus on inhibition of EWSR1 (show EWSR1 Proteins)-FLI1 and its effectors has produced promising results.
Fusion of short fragments of EWSR1 (show EWSR1 Proteins) to FLI1 is sufficient to recapitulate BAF (show BANF1 Proteins) complex retargeting and EWS (show EWSR1 Proteins)-FLI1 activities; studies thus demonstrate that the physical properties of prion (show PRNP Proteins)-like domains can retarget critical chromatin regulatory complexes to establish and maintain oncogenic gene expression programs.
In American cutaneous leishmaniasis caused by Leishmania braziliensis infection, MMP1 (show MMP1 Proteins) is regulated by factors other than FLI1, and the influence of IL-6 (show IL6 Proteins) on MMP1 (show MMP1 Proteins) was independent of its effect on FLI1.
epithelial Fli1 deficiency might be involved in the systemic autoimmunity and selective organ fibrosis in systemic sclerosis (SSc (show CYP11A1 Proteins)).
Study found consistent DNA hypomethylation at enhancers regulated by the disease-defining EWS (show EWSR1 Proteins)-FLI1 fusion protein, thus establishing epigenomic enhancer reprogramming as a ubiquitous and characteristic feature of Ewing sarcoma.
loss of ERG (show ERG Proteins) and FLI1 might contribute to the pathogenesis of vascular lung complications through the induction of inflammation.
study shows that FLI-1 is expressed variably in different subtypes of NSCLC, and its expression is related to clinicopathologic parameters and poorer prognosis
ERG (show ERG Proteins) (or FLI1 if available) is useful marker for the diagnosis of Phosphaturic mesenchymal tumors.
These results provide the first evidences that Fli-1 positively regulates LPS (show TLR4 Proteins)-induced IL-27 (show IL27 Proteins) production in macrophages
protective against nephritis MRL/lpr (show FAS Proteins) mice
Fli1 is epigenetically suppressed and is a potential predisposing factor in the pathogenesis of systemic sclerosis. (Review)
The short nose, otitis media, and hearing impairment in Jacobsen syndrome are likely because of hemizygosity for ETS1 (show ETS1 Proteins) and FLI1.
Simultaneous downregulation of KLF5 (show KLF5 Proteins) and Fli1 is a key feature underlying systemic sclerosis.
bosentan...increased DNA binding of Fli1 and the suppression of type I collagen expression in systemic sclerosis fibroblasts
FLI1 and GATA2 (show GATA2 Proteins) are upstream regulators of SMAD1 (show SMAD1 Proteins) and SMAD5 (show SMAD5 Proteins) expression in endothelial cells.
These results demonstrate that Fli-1 is a novel regulator of the proinflammatory chemokine (show CCL1 Proteins) MCP-1 (show CPT1B Proteins).
Fli-1 directly increases the expression of IL-6 (show IL6 Proteins) via promoter region binding. This represents one possible mechanism for the protective effect of decreased Fli-1 expression in lupus.
mesodermal Wnt3a (show WNT3A Proteins)-mediated signaling via the transcription factor Lef1 (show LEF1 Proteins) positively regulates EC specification (defined by kdrl expression) at the expense of primitive erythrocyte specification (defined by gata1 (show GATA1 Proteins) expression) in zebrafish embryos.
Fli+ etsrp (show ETV2 Proteins)+ hemato-vascular progenitor cells proliferate at the lateral plate mesoderm during vasculogenesis in zebrafish.
These results showed that young thrombocytes have higher GATA1 (show GATA1 Proteins) promoter activity, while mature thrombocytes have more fli1 gene promoter transcription.
fli1, and etsrp (show ETV2 Proteins), demonstrated that erg (show KCNH2 Proteins) and fli1 act cooperatively and are required for angiogenesis possibly via direct regulation of an endothelial cell junction molecule, VE-cadherin (show CDH5 Proteins)
Interaction between EWSR1 (show EWSR1 Proteins)/FLI1 and EWSR1 (show EWSR1 Proteins) in Ewing sarcoma may induce mitotic defects leading to genomic instability and subsequent malignant transformation.
This gene encodes a transcription factor containing an ETS DNA-binding domain. The gene can undergo a t(11\;22)(q24\;q12) translocation with the Ewing sarcoma gene on chromosome 22, which results in a fusion gene that is present in the majority of Ewing sarcoma cases. An acute lymphoblastic leukemia-associated t(4\;11)(q21\;q23) translocation involving this gene has also been identified. Alternative splicing results in multiple transcript variants.
Ewing sarcoma breakpoint region 2
, Friend leukemia integration 1 transcription factor
, Friend leukemia virus integration 1
, proto-oncogene Fli-1
, transcription factor ERGB
, fli-1 proto-oncogene
, friend leukemia integration 1 transcription factor-like
, Friend leukemia integration 1 transcription factor-like
, retroviral integration site protein Fli-1
, retroviral integration site protein Fli-1 homolog