Friend Leukemia Virus Integration 1 Proteins (FLI1)

FLI1 encodes a protein with a gelsolin-like actin binding domain and an N-terminal leucine-rich repeat-protein protein interaction domain. Additionally we are shipping Friend Leukemia Virus Integration 1 Antibodies (170) and Friend Leukemia Virus Integration 1 Kits (4) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
FLI1 2313 Q01543
FLI1 315532  
FLI1 14247 P26323
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Top Friend Leukemia Virus Integration 1 Proteins at antibodies-online.com

Showing 7 out of 8 products:

Catalog No. Origin Source Conjugate Images Quantity Delivery Price Details
Insect Cells Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg 60 Days
$9,626.73
Details
Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg 30 to 35 Days
$5,370.21
Details
HEK-293 Cells Human Myc-DYKDDDDK Tag Validation with Western Blot 20 μg 11 Days
$888.80
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Escherichia coli (E. coli) Human Un-conjugated SDS-PAGE analysis of Human FLI1 Protein. 100 μg 11 to 18 Days
$639.61
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Yeast Cow His tag   1 mg 60 to 71 Days
$3,268.83
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Yeast Xenopus laevis His tag   1 mg 60 to 71 Days
$3,272.50
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Escherichia coli (E. coli) Cat Un-conjugated   5 applications 1 to 2 Days
$318.85
Details

FLI1 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , ,
, ,
Rat (Rattus)
Mouse (Murine)

More Proteins for Friend Leukemia Virus Integration 1 (FLI1) Interaction Partners

Human Friend Leukemia Virus Integration 1 (FLI1) interaction partners

  1. FLI-1 is a novel and an extremely useful predictor for the poor prognosis in patients with breast cancer. The modulation of FLI-1 affected the mesenchymal characteristics, which was consistent with the changes in CSC-like phenotype. FLI-1 can induce EMT by binding to the promoters of EMT-related key genes (CDH1 and VIM), sustain CSC-like properties, and influence tumorigenesis in vivo.

  2. e describe the dependency of EWS/ETS-driven transcription upon chromatin reader BET bromdomain proteins and investigate the potential of BET inhibitors in treating EWS. EWS/FLI1 and EWS/ERG were found in a transcriptional complex with BRD4, and knockdown of BRD2/3/4 significantly impaired the oncogenic phenotype of EWS cells. RNA-seq analysis following BRD4 knockdown or inhibition with JQ1 revealed an attenuated EWS/ETS

  3. the forward programming of human pluripotent stem cells through overexpression of GATA1, FLI1, and TAL1 leads to the production of a population of progenitors that can differentiate into megakaryocyte or erythroblasts.

  4. co-activation of FLI1 and PKC could induce differentiation of human embryonic stem cells into induced endothelial cells in a fast, efficient and economic manner.

  5. FECR1, a circular RNA in the FLI1 promoter chromatin complex, consisting of FLI1 exons 4-2-3, acts as an upstream regulator to control breast cancer tumor growth by coordinating the regulation of DNA methylating and demethylating enzymes.

  6. Combined knockdown of two ETS family transcription factors, ERG and FLI1, induces endothelial-to-mesenchymal transition coupled with dynamic epigenetic changes in endothelial cells.

  7. TAL1 mediates the function of MEIS1 in hemogenic endothelial progenitors specification. In addition, MEIS1 is vital for megakaryopoiesis and thrombopoiesis from hPSCs. Mechanistically, FLI1 acts as a downstream gene necessary for the function of MEIS1 during megakaryopoiesis

  8. Comparative structure analysis of the ETSi domain of ERGB and its complex with the E74 promoter DNA sequence has been presented.

  9. These results indicate that Fli1 deficiency promotes migration, proliferation and cell survival, while abating tube formation of endothelial cells, suggesting that Fli1 deficiency is potentially attributable to the development of both proliferative obliterative vasculopathy (occlusion of arterioles and small arteries) and destructive vasculopathy (loss of small vessels) characteristic of SSc vasculopathy.

  10. Fli1 functioned as an oncogene in HCC carcinogenesis and it exerted its promoting metastatic effect primarily by modulating the matrix metalloproteinase (MMP)2 signaling pathway.

  11. Decreased serum LIF levels may be associated with vasculopathy in systemic sclerosis (SSc) and that Fli1 deficiency may contribute to the inhibition of LIF-dependent biological effects on SSc endothelial cells by suppressing the expression of LIF, LIF receptor, and gp130.

  12. Studies demonstrate that the translocation-derived fusion protein EF (EWS-FLI1) misregulates numerous genes involved in metabolism suggesting that EF is a master regulator of metabolic reprogramming in Ewing sarcoma, diverting metabolites toward biosynthesis.

  13. The gene that was most reproducibly up-regulated by EWS/FLI was NR0B1.

  14. The mouse (Fli1) and human Fli1 genes are similarly regulated by Ets factors in T cells.

  15. In contrast, expression of Spi1/PU.1 in a Fli1 producing erythroleukemia cell line in which fli1 is activated, resulted in increased proliferation through activation of growth promoting proteins MAPK, AKT, cMYC and JAK2

  16. CXCL6 expression is upregulated by Fli1 deficiency in fibroblasts and endothelial cells, potentially contributing to the development of fibrosis and vasculopathy in the skin, lung, and heart of systemic sclerosis.

  17. This is the first report presenting CD13 and FLI1 as important mediators of resistance to BRAF inhibition with potential as drug targets in BRAF inhibitors refractory melanoma.

  18. This study uncovers FLI1 as an important driving factor that promotes tumor growth in SCLC through the miR-17-92 pathway. FLI1 may serve as an attractive target for therapeutic intervention of SCLC.

  19. identification of two novel FLI1 variants (c.1010G>A and c.1033A>G) responsible for macrothrombocytopenia; study provides new insights into the phenotype, pathophysiology and diagnosis of FLI1 variant-associated thrombocytopenia

  20. miR-145 acts as a tumor suppressor by directly reducing expression of FLI-1, and the miR-145/FLI-1 pathway is important for tumor progression in osteosarcoma

Xenopus laevis Friend Leukemia Virus Integration 1 (FLI1) interaction partners

  1. at the top of the transcriptional regulatory hierarchy for hemangioblast specification in vertebrate embryos

Mouse (Murine) Friend Leukemia Virus Integration 1 (FLI1) interaction partners

  1. These results indicate that Fli1 loss promotes CXCL13 expression in macrophages even though stimulated with LPS, a potent inhibitory factor for CXCL13 expression.

  2. Data suggest a critical role of Friend leukemia integration 1 protein (Fli1) deficiency in the interaction of dermal fibroblasts with immune cells in pathological skin fibrosis.

  3. findings demonstrated a novel role and mechanism of Fli-1 in regulating caspase-1 expression in lung pericytes.

  4. the Fox transcription factor binding motif was frequently observed within EWS-FLI1 peaks and Foxq1 was identified as the cooperative partner that interacts with the EWS portion of EWS-FLI1.

  5. Decreased serum LIF levels may be associated with vasculopathy in systemic sclerosis (SSc) and that Fli1 deficiency may contribute to the inhibition of LIF-dependent biological effects on SSc endothelial cells by suppressing the expression of LIF, LIF receptor, and gp130.

  6. Histones showed limited activation in regions of single TF binding, while enhancers that bind NF-E2 and either RUNX1, FLI1 or both TFs gave the highest signals for TF occupancy and H3K4me2; these enhancers associated best with genes activated late in MK maturation.

  7. loss of ERG and FLI1 might contribute to the pathogenesis of vascular lung complications through the induction of inflammation.

  8. These results provide the first evidences that Fli-1 positively regulates LPS-induced IL-27 production in macrophages

  9. protective against nephritis MRL/lpr mice

  10. Fli1 is epigenetically suppressed and is a potential predisposing factor in the pathogenesis of systemic sclerosis. (Review)

  11. The short nose, otitis media, and hearing impairment in Jacobsen syndrome are likely because of hemizygosity for ETS1 and FLI1.

  12. Simultaneous downregulation of KLF5 and Fli1 is a key feature underlying systemic sclerosis.

  13. It is a predisposing factor of systemic sclerosis. (review)

  14. bosentan...increased DNA binding of Fli1 and the suppression of type I collagen expression in systemic sclerosis fibroblasts

  15. FLI1 and GATA2 are upstream regulators of SMAD1 and SMAD5 expression in endothelial cells.

  16. These results demonstrate that Fli-1 is a novel regulator of the proinflammatory chemokine MCP-1.

  17. Fli-1 directly increases the expression of IL-6 via promoter region binding. This represents one possible mechanism for the protective effect of decreased Fli-1 expression in lupus.

  18. reducing FLI1 in lupus decreases the pathogenicity of T cells by decreasing TCR-specific activation and IL-4 production in part through the modulation of glycosphingolipid metabolism

  19. Fli-1 is a novel and critical regulator of proinflammatory chemokines and affects the pathogenesis of disease through the regulation of factors that recruit inflammatory cells to sites of inflammation.

  20. Fli-1 plays a critical role in both the DN2 to DN3 transition and alphabeta/gammadelta lineage commitment.

Zebrafish Friend Leukemia Virus Integration 1 (FLI1) interaction partners

  1. mesodermal Wnt3a-mediated signaling via the transcription factor Lef1 positively regulates EC specification (defined by kdrl expression) at the expense of primitive erythrocyte specification (defined by gata1 expression) in zebrafish embryos.

  2. Fli+ etsrp+ hemato-vascular progenitor cells proliferate at the lateral plate mesoderm during vasculogenesis in zebrafish.

  3. These results showed that young thrombocytes have higher GATA1 promoter activity, while mature thrombocytes have more fli1 gene promoter transcription.

  4. fli1, and etsrp, demonstrated that erg and fli1 act cooperatively and are required for angiogenesis possibly via direct regulation of an endothelial cell junction molecule, VE-cadherin

  5. Interaction between EWSR1/FLI1 and EWSR1 in Ewing sarcoma may induce mitotic defects leading to genomic instability and subsequent malignant transformation.

Friend Leukemia Virus Integration 1 (FLI1) Protein Profile

Protein Summary

This gene encodes a transcription factor containing an ETS DNA-binding domain. The gene can undergo a t(11\;22)(q24\;q12) translocation with the Ewing sarcoma gene on chromosome 22, which results in a fusion gene that is present in the majority of Ewing sarcoma cases. An acute lymphoblastic leukemia-associated t(4\;11)(q21\;q23) translocation involving this gene has also been identified. Alternative splicing results in multiple transcript variants.

Gene names and symbols associated with FLI1

  • Fli-1 proto-oncogene, ETS transcription factor (FLI1)
  • Fli-1 proto-oncogene, ETS transcription factor (Fli1)
  • Fli-1 proto-oncogene, ETS transcription factor S homeolog (fli1.S)
  • Fli-1 proto-oncogene, ETS transcription factor (fli1)
  • Friend leukemia integration 1 (Fli1)
  • Fli-1 proto-oncogene, ETS transcription factor a (fli1a)
  • Fli-1 proto-oncogene, ETS transcription factor L homeolog (fli1.L)
  • cb855 protein
  • EWSR2 protein
  • fli protein
  • Fli-1 protein
  • fli1 protein
  • MGC121593 protein
  • SIC-1 protein
  • Sic1 protein
  • wu:fc45b11 protein
  • Xfli protein
  • Xfli-1 protein
  • Xfli1 protein
  • xlfli protein

Protein level used designations for FLI1

Ewing sarcoma breakpoint region 2 , Friend leukemia integration 1 transcription factor , Friend leukemia virus integration 1 , proto-oncogene Fli-1 , transcription factor ERGB , fli-1 proto-oncogene , friend leukemia integration 1 transcription factor-like , Friend leukemia integration 1 transcription factor-like , retroviral integration site protein Fli-1 , retroviral integration site protein Fli-1 homolog

GENE ID SPECIES
2313 Homo sapiens
315532 Rattus norvegicus
419723 Gallus gallus
451659 Pan troglodytes
489286 Canis lupus familiaris
529124 Bos taurus
100020764 Monodelphis domestica
100036985 Xenopus laevis
100124738 Xenopus (Silurana) tropicalis
100338376 Oryctolagus cuniculus
100411928 Callithrix jacchus
100445127 Pongo abelii
100469052 Ailuropoda melanoleuca
100545965 Meleagris gallopavo
100607271 Nomascus leucogenys
14247 Mus musculus
30619 Danio rerio
399466 Xenopus laevis
100064591 Equus caballus
100716275 Cavia porcellus
101090716 Felis catus
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