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FLI1 encodes a transcription factor containing an ETS DNA-binding domain. Additionally we are shipping Friend Leukemia Virus Integration 1 Antibodies (184) and Friend Leukemia Virus Integration 1 Kits (7) and many more products for this protein.
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Low FLII (show FLII Proteins) expression is associated with lung carcinoma.
These results indicate that Fli1 deficiency promotes migration, proliferation and cell survival, while abating tube formation of endothelial cells, suggesting that Fli1 deficiency is potentially attributable to the development of both proliferative obliterative vasculopathy (occlusion of arterioles and small arteries) and destructive vasculopathy (loss of small vessels) characteristic of SSc (show CYP11A1 Proteins) vasculopathy.
Fli1 functioned as an oncogene (show RAB1A Proteins) in HCC (show FAM126A Proteins) carcinogenesis and it exerted its promoting metastatic effect primarily by modulating the matrix metalloproteinase (MMP)2 (show MMP2 Proteins) signaling pathway.
Decreased serum LIF levels may be associated with vasculopathy in systemic sclerosis (SSc) and that Fli1 deficiency may contribute to the inhibition of LIF-dependent biological effects on SSc endothelial cells by suppressing the expression of LIF, LIF receptor, and gp130.
Studies demonstrate that the translocation-derived fusion protein EF (EWS (show EWSR1 Proteins)-FLI1) misregulates numerous genes involved in metabolism suggesting that EF is a master regulator of metabolic reprogramming in Ewing sarcoma, diverting metabolites toward biosynthesis.
Data show that the ability of Ca(2+) to accentuate the activity of NLRP3 inflammasome is abrogated in Flightless-I (FliI) and leucine-rich repeat FliI-interaction protein 2 (LRRFIP2)-knockdown macrophages.
Together, the data demonstrate the critical requirement of GGAA-microsatellites as EWS (show EWSR1 Proteins)/FLI (show FLII Proteins) activating response elements in vivo and reveal an unexpected role for the EWS (show EWSR1 Proteins) portion of the EWS (show EWSR1 Proteins)/FLI (show FLII Proteins) fusion in binding to sweet-spot GGAA-microsatellites.
FLII (show FLII Proteins) is a component of the ChREBP (show MLXIPL Proteins) transcriptional complex and negatively regulates ChREBP (show MLXIPL Proteins) function in cancer cells.
Demonstrate an important role for Flii (show FLII Proteins) in the development and regulation of the epidermal barrier, which may contribute to the impaired healing and skin fragility of epidermolysis bullosa patients.
The gene that was most reproducibly up-regulated by EWS (show EWSR1 Proteins)/FLI (show FLII Proteins) was NR0B1 (show NR0B1 Proteins).
the Fox transcription factor binding motif was frequently observed within EWS (show EWSR1 Proteins)-FLI1 peaks and Foxq1 (show FOXQ1 Proteins) was identified as the cooperative partner that interacts with the EWS (show EWSR1 Proteins) portion of EWS (show EWSR1 Proteins)-FLI1.
Histones showed limited activation in regions of single TF binding, while enhancers that bind NF-E2 (show NFE2 Proteins) and either RUNX1 (show RUNX1 Proteins), FLI1 or both TFs gave the highest signals for TF occupancy and H3K4me2; these enhancers associated best with genes activated late in MK maturation.
loss of ERG (show ERG Proteins) and FLI1 might contribute to the pathogenesis of vascular lung complications through the induction of inflammation.
These results provide the first evidences that Fli-1 positively regulates LPS (show TLR4 Proteins)-induced IL-27 (show IL27 Proteins) production in macrophages
protective against nephritis MRL/lpr (show FAS Proteins) mice
Fli1 is epigenetically suppressed and is a potential predisposing factor in the pathogenesis of systemic sclerosis. (Review)
The short nose, otitis media, and hearing impairment in Jacobsen syndrome are likely because of hemizygosity for ETS1 (show ETS1 Proteins) and FLI1.
Simultaneous downregulation of KLF5 (show KLF5 Proteins) and Fli1 is a key feature underlying systemic sclerosis.
bosentan...increased DNA binding of Fli1 and the suppression of type I collagen expression in systemic sclerosis fibroblasts
mesodermal Wnt3a (show WNT3A Proteins)-mediated signaling via the transcription factor Lef1 (show LEF1 Proteins) positively regulates EC specification (defined by kdrl expression) at the expense of primitive erythrocyte specification (defined by gata1 (show GATA1 Proteins) expression) in zebrafish embryos.
Fli+ etsrp (show ETV2 Proteins)+ hemato-vascular progenitor cells proliferate at the lateral plate mesoderm during vasculogenesis in zebrafish.
These results showed that young thrombocytes have higher GATA1 (show GATA1 Proteins) promoter activity, while mature thrombocytes have more fli1 gene promoter transcription.
fli1, and etsrp (show ETV2 Proteins), demonstrated that erg (show KCNH2 Proteins) and fli1 act cooperatively and are required for angiogenesis possibly via direct regulation of an endothelial cell junction molecule, VE-cadherin (show CDH5 Proteins)
Interaction between EWSR1 (show EWSR1 Proteins)/FLI1 and EWSR1 (show EWSR1 Proteins) in Ewing sarcoma may induce mitotic defects leading to genomic instability and subsequent malignant transformation.
This gene encodes a protein with a gelsolin-like actin binding domain and an N-terminal leucine-rich repeat-protein protein interaction domain. The protein is similar to a Drosophila protein involved in early embryogenesis and the structural organization of indirect flight muscle. The gene is located within the Smith-Magenis syndrome region on chromosome 17.
Ewing sarcoma breakpoint region 2
, Friend leukemia integration 1 transcription factor
, Friend leukemia virus integration 1
, proto-oncogene Fli-1
, transcription factor ERGB
, protein flightless-1 homolog
, fli-1 proto-oncogene
, friend leukemia integration 1 transcription factor-like
, Friend leukemia integration 1 transcription factor-like
, retroviral integration site protein Fli-1
, retroviral integration site protein Fli-1 homolog