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L-fucose is a key sugar in glycoproteins and other complex carbohydrates since it may be involved in many of the functional roles of these macromolecules, such as in cell-cell recognition. Additionally we are shipping FPGT Proteins (9) and and many more products for this protein.
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the nature of the purine base is the major determinant in substrate specificity, followed by the nature of the hexose-1-P, and finally by the ribose moiety. Binding is enthalpy-driven and does not involve proton transfer
identified five amino acid residues that are critical for catalysis.
A complete native data set has been collected as a first step in determining the three-dimensional structure of this enzyme.
Data identified Tnni3k, Fpgt and H28 as likely likely candidates for Vms1.
cloning, expression and tissue distribution of murine L-fucokinase and GDP-L-fucose pyrophosphorylase
L-fucose is a key sugar in glycoproteins and other complex carbohydrates since it may be involved in many of the functional roles of these macromolecules, such as in cell-cell recognition. The fucosyl donor for these fucosylated oligosaccharides is GDP-beta-L-fucose. There are two alternate pathways for the biosynthesis of GDP-fucose\; the major pathway converts GDP-alpha-D-mannose to GDP-beta-L-fucose. The protein encoded by this gene participates in an alternate pathway that is present in certain mammalian tissues, such as liver and kidney, and appears to function as a salvage pathway to reutilize L-fucose arising from the turnover of glycoproteins and glycolipids. This pathway involves the phosphorylation of L-fucose to form beta-L-fucose-1-phosphate, and then condensation of the beta-L-fucose-1-phosphate with GTP by fucose-1-phosphate guanylyltransferase to form GDP-beta-L-fucose. Alternative splicing results in multiple transcript variants. Read-through transcription also exists between this gene and the neighboring downstream TNNI3 interacting kinase (TNNI3K) gene.
, Fucose-1-phosphate guanylyltransferase
, fucose-1-phosphate guanylyltransferase-like
, GDP-L-fucose diphosphorylase
, GDP-beta-L-fucose pyrophosphorylase
, fucose-1-phosphate guanyltransferase
, gdp-L-fucose pyrophosphorylase