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The Lewis histo-blood group system comprises a set of fucosylated glycosphingolipids that are synthesized by exocrine epithelial cells and circulate in body fluids. Additionally we are shipping FUT3 Kits (14) and FUT3 Proteins (7) and many more products for this protein.
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High FUT3 expression is associated with breast cancer.
the high expressions of BCL6 (show BCL6 Antibodies) and Lewis y antigen are associated with development, high tumor burden, and worse prognosis of ovarian cancer and targeting BCL6 (show BCL6 Antibodies) could be a novel therapeutic strategy for ovarian cancer treatment.
the miRNA expression vector which targets the FUT3 gene can effectively inhibit the proliferation, migration and invasion abilities of KATO-III cells.
Polymorphisms in FUT3 and its intestinal expression might be associated with ulcerative colitis pathogenesis.
Data suggest that fucosyltransferase 3 (FUT3) gene rs28362459 and rs3745635 single nucleotide polymorphisms (SNPs) may engender the increased risk of ileocolonic and ileal Crohn's disease (CD).
Mutations of FUT3 (rs28362459) and (rs3745635) might influence the lesion locations in CD patients.
Use of FUT2 (show FUT2 Antibodies)/3 genotype-dependent cut-off values for CA19-9 improved sensitivity and reduced the number of false positive results
Obtained FST (show FST Antibodies) values reveal distinct frequencies of the FUT3 SNPs between the present sample and its representative ancestral populations.
down-regulation of FUT3 and FUT5 reduces the expression of sialyl-Lewis antigens and the adhesion capacities of gastric cancer cells and allows to identify the specific alpha1-3,4 fucosyltransferases implicated in the Lewis antigens synthesis
Elevated expression of Topo-I (show TOP1 Antibodies) and Topo-II beta (show TOP2B Antibodies) is found in Lewis(y) antigen-overexpressing ovarian cancer cells.
The Lewis histo-blood group system comprises a set of fucosylated glycosphingolipids that are synthesized by exocrine epithelial cells and circulate in body fluids. The glycosphingolipids function in embryogenesis, tissue differentiation, tumor metastasis, inflammation, and bacterial adhesion. They are secondarily absorbed to red blood cells giving rise to their Lewis phenotype. This gene is a member of the fucosyltransferase family, which catalyzes the addition of fucose to precursor polysaccharides in the last step of Lewis antigen biosynthesis. It encodes an enzyme with alpha(1,3)-fucosyltransferase and alpha(1,4)-fucosyltransferase activities. Mutations in this gene are responsible for the majority of Lewis antigen-negative phenotypes. Multiple alternatively spliced variants, encoding the same protein, have been found for this gene.
, blood group Lewis alpha-4-fucosyltransferase
, fucosyltransferase III
, galactoside 3(4)-L-fucosyltransferase
, fucosyltransferase 3 (galactoside 3(4)-L-fucosyltransferase, Lewis blood group)
, FUT Lewis
, alpha 1,3/4 fucosyltransferase Lewis 2
, alpha 1,3/4 fucosyltransferase Lewis 1
, fucosyltransferase 5
, lewis FT