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High FUT3 expression is associated with breast cancer.
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the high expressions of BCL6 and Lewis y antigen are associated with development, high tumor burden, and worse prognosis of ovarian cancer and targeting BCL6 could be a novel therapeutic strategy for ovarian cancer treatment.
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the miRNA expression vector which targets the FUT3 gene can effectively inhibit the proliferation, migration and invasion abilities of KATO-III cells.
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Polymorphisms in FUT3 and its intestinal expression might be associated with ulcerative colitis pathogenesis.
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Data suggest that fucosyltransferase 3 (FUT3) gene rs28362459 and rs3745635 single nucleotide polymorphisms (SNPs) may engender the increased risk of ileocolonic and ileal Crohn's disease (CD).
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that the absence of alpha1,3/4-fucosyltransferase enzyme is related to breast's invasive breast carcinoma
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Mutations of FUT3 (rs28362459) and (rs3745635) might influence the lesion locations in CD patients.
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Use of FUT2/3 genotype-dependent cut-off values for CA19-9 improved sensitivity and reduced the number of false positive results
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Obtained FST values reveal distinct frequencies of the FUT3 SNPs between the present sample and its representative ancestral populations.
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down-regulation of FUT3 and FUT5 reduces the expression of sialyl-Lewis antigens and the adhesion capacities of gastric cancer cells and allows to identify the specific alpha1-3,4 fucosyltransferases implicated in the Lewis antigens synthesis
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Elevated expression of Topo-I and Topo-II beta is found in Lewis(y) antigen-overexpressing ovarian cancer cells.
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LeY is carried by integrin alphavbeta3 and plays a critical role in attachment to cultured cells. LeY activates integrin alphavbeta3/focal adhesion kinase (FAK) signaling.
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At physiological levels of wall shear stress, the number of flowing cancer cells recruited to the microtube surface was dramatically reduced by FUT3 knockdown
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Lewis-negative genotype was associated with invasive ductal breast carcinoma but not with anatomoclinical parameters
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GALNT14 and FUT3/6 H-scores were significantly higher in non-small cell lung cancer cell lines sensitive to dulanermin and drozitumab versus resistant cell lines
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Increased expression of Lewis y antigen plays an important role in promoting cell proliferation through activating PI3K/Akt signaling pathway in ovarian carcinoma-derived RMG-I cells.
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PCR using sequence-specific primers DNA enables efficient genotyping of clinical samples
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Sialy Lewis-X antigens play an important role liver metastases of colon carcinoma.
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Distribution of Lewis (FUT3)genotype and allele frequencies by ethnicity in a United States population.
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Cys, Gln, and Tyr residues are important for FT3wt sorting into the transport vesicles possibly due to interactions with other membrane proteins
