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GPR64 encodes a member of the G protein-coupled receptor family described as an epididymis-specific transmembrane protein.
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identified two missense variants in two congenital bilateral absence of the vas (show AVP Antibodies) deferens (CBAVD) patients (c.G1709A, p.C570Y; and c.A2968G, p.K990E); study did not find any potential pathogenic CFTR (show CFTR Antibodies) variants, implying the ADGRG2 variants are the genetic cause in these patients
GPR64 is expressed on the cell surface of parathyroid cells, is overexpressed in parathyroid tumors, and physically interacts with the CaSR (show CASR Antibodies).
study confirms the crucial role of ADGRG2 in human male fertility and brings new insight into congenital obstructive azoospermia pathogenesis; in men with CBAVD who are CFTR (show CFTR Antibodies)-negative, ADGRG2 testing could allow for appropriate genetic counseling with regard to the X-linked transmission of the molecular defect
Knockdown of ADGRG2 breast cancer cell lines resulted in a strong reduction in cell adhesion and subsequent cell migration which was associated with a selective reduction in RelB (show RELB Antibodies).
examined the G protein-coupling abilities of GPR64 and showed that it is activated through a tethered agonist sequence, which we have previously identified as the Stachel sequence
GPR64 expression in ES maintains an immature phenotype that is less sensitive to TRAIL-induced apoptosis and via its up-regulation of PGF (show PTGFR Antibodies) and MMP1 (show MMP1 Antibodies) orchestrates and promotes invasiveness and metastatic spread in Ewing sarcoma.
The knockout of the HE6/Gpr64 receptor was mainly associated with the downregulation of genes specific to the initial segment.
Affymetrix expression profiling shows that the C terminus of Runx2 (show RUNX2 Antibodies) regulates genes involved in G protein-coupled receptor (show GPR34 Antibodies) signaling Rgs2 (show RGS2 Antibodies), Rgs4 (show RGS4 Antibodies), Rgs5 (show RGS5 Antibodies), Rgs16 (show RGS16 Antibodies), Gpr23 (show LPAR4 Antibodies), Gpr30 (show GPER Antibodies), Gpr54 (show KISS1R Antibodies), Gpr64, and Gna13 (show GNA13 Antibodies).
This gene encodes a member of the G protein-coupled receptor family described as an epididymis-specific transmembrane protein. The encoded protein may be proteolytically processed as it contains a motif shown to be a protein scission motif in some members of this family (PMID: 11973329). Multiple transcript variants encoding different isoforms have been found for this gene.
G protein-coupled receptor 64
, G-protein coupled receptor 64-like
, G protein-coupled receptor, epididymis-specific (seven transmembrane family)
, G-protein coupled receptor 64
, epididymal protein 6
, human epididymis-specific protein 6
, LNB-TM7 heptahelical receptor Me6
, epididymis-specific protein 6
, re6 receptor