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Orphan receptor. Additionally we are shipping GPR78 Kits (17) and GPR78 Proteins (4) and many more products for this protein.
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We reveal distinct binding affinities between the binary and ternary complexes thus formed, that suggest a preference for the PERK (show EIF2AK3 Antibodies) signaling branch under stress, and a predilection for the GRP78 (show HSPA5 Antibodies)-UPR sensor complex formation upon stressor removal. These results imply a gated UPR mechanism that tunes the overall cellular behavior to the accumulation of unfolded proteins.
Knockdown of GPR78 in lung cancer cells suppressed cell migration and GPR78 modulated the formation of actin stress fibers in A549 cells, in a RhoA (show RHOA Antibodies)- and Rac1 (show RAC1 Antibodies)-dependent manner.
Two haplotypes remained significant in both the female bipolar affective disorder individuals and in the full sample of affected female individuals. Results provide preliminary evidence for involvement of GPR78 in susceptibility to BPAD and SCZ.
Orphan receptor. Displays a significant level of constitutive activity. Its effect is mediated by G(s)-alpha protein that stimulate adenylate cyclase, resulting in an elevation of intracellular cAMP.
G-protein coupled receptor 78
, G protein-coupled receptor 78