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G protein-coupled receptors (GPCRs, or GPRs), such as GPR81, contain 7 transmembrane domains and transduce extracellular signals through heterotrimeric G proteins.. Additionally we are shipping G Protein-Coupled Receptor 81 Proteins (4) and and many more products for this protein.
Showing 10 out of 96 products:
Human Polyclonal GPR81 Primary Antibody for IHC (p) - ABIN4315865
Jeninga, Bugge, Nielsen, Kersten, Hamers, Dani, Wabitsch, Berger, Stunnenberg, Mandrup, Kalkhoven: Peroxisome proliferator-activated receptor gamma regulates expression of the anti-lipolytic G-protein-coupled receptor 81 (GPR81/Gpr81). in The Journal of biological chemistry 2009
Human Polyclonal GPR81 Primary Antibody for ELISA, WB - ABIN4274870
Cai, Ren, Jin, Cheng, Kash, Chen, Wright, Taggart, Waters: Role of GPR81 in lactate-mediated reduction of adipose lipolysis. in Biochemical and biophysical research communications 2008
lactate can induce GPR81-independent metabolic changes that modulate macrophage pro-inflammatory activation.
GPR81 expression increased during gestation, and peaked near labor. GPR81 is expressed in the uterus with high expression in myometrium. GPR81 mediates inflammation in the laboring uterus.
Results indicate that lactate may aggravated ischemic brain injury by activating GPR81 and inhibition of GPR81 protects against ischemia-induced cell death via an antiapoptosis pathway
Description of a GPR81 selective agonist with in vivo efficacy, inhibiting lipolysis without flushing.
Lactate negatively regulates TLR induction of the NLRP3 (show NLRP3 Antibodies) inflammasome and production of IL1beta (show IL1B Antibodies), via ARRB2 (show ARRB2 Antibodies) and GPR81 in liver and pancreatic injury.
chronic obesity reduces GPR109A (show HCAR2 Antibodies) and GPR81 expression in the adipose tissue, while acute in vitro LPS (show TLR4 Antibodies) treatment increases expression of GPR109A (show HCAR2 Antibodies) in adipocytes and macrophages.
Inflammation decreases the expression of GPR81 in adipose tissue
An autocrine lactate loop mediates insulin (show INS Antibodies)-dependent inhibition of lipolysis through GPR81.
GPR81 couples to the Gi signaling pathway
Data show that siRNA-mediated knockdown (show PPARG Antibodies)of PPARgamma in differentiated 3T3-L1 adip (show HCAR2 Antibodies)ocytes showe (show HCAR3 Antibodies)d a significant decrease in Gpr81 protein expression.
The novel role of HCAR1 in development of chemoresistance in cervical carcinoma HeLa cells via ABCB1 (show ABCB1 Antibodies) transporter up-regulation.
Findings identify GPR81 as a tumor-promoting receptor in breast cancer progression and suggest a novel mechanism that regulates GPR81-dependent activation of the PI3K (show PIK3CA Antibodies)/Akt (show AKT1 Antibodies) signaling axis in tumor microenvironment.
Activation of GPR81 decreases intracellular cAMP levels and inhibits PKA activity, leading to activation of TAZ (show TAZ Antibodies) and upregulation of PD-L1 (show CD274 Antibodies). This study reveals a critical role for lactate in the immune checkpoint pathway and an unexpected function of TAZ (show TAZ Antibodies) in tumor evasion of the T-cell-mediated immune response.
Lactate receptor/HCAR1 expression in cervical carcinoma cells may contribute to the modulation of cellular DNA repair mechanisms.
HCA1/3 are necessary for breast cancer cells to balance lipid/fatty acid metabolism.
HCAR1 and monocarboxylate transporters activity is required for the L- and D-lactate-mediated enhancement of DNA repair and of HeLa cell survival.
Data support that GPR81 is important for cancer cell regulation of lactate transport mechanisms.
demonstrated that the C165-E166-S167-F168 motif at the second extracellular loop is critical for GPR81 function, and the conserved six Cys (show DNAJC5 Antibodies) residues at the extracellular regions are necessary for GPR81 function
G protein-coupled receptors (GPCRs, or GPRs), such as GPR81, contain 7 transmembrane domains and transduce extracellular signals through heterotrimeric G proteins.
G protein-coupled receptor 81
, G-protein coupled receptor 81
, hydroxycarboxylic acid receptor 1
, G protein-coupled receptor 104
, G-protein coupled receptor 104
, T-cell activation G protein-coupled receptor
, hydroxy-carboxylic acid receptor 1
, lactate receptor 1