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The SLC6A1 gene encodes a gamma-aminobutyric acid (GABA) transporter, which removes GABA from the synaptic cleft (Hirunsatit et al., 2009 [PubMed 19077666]).[supplied by OMIM, Jul 2009].. Additionally we are shipping and many more products for this protein.
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Dog (Canine) Polyclonal GAT1 Primary Antibody for ELISA, WB - ABIN4273530
de Krom, Staal, Ophoff, Hendriks, Buitelaar, Franke, de Jonge, Bolton, Collier, Curran, van Engeland, van Ree: A common variant in DRD3 receptor is associated with autism spectrum disorder. in Biological psychiatry 2009
Rat (Rattus) Polyclonal GAT1 Primary Antibody for ICC, IHC - ABIN1742535
Aracri, Meneghini, Coatti, Amadeo, Becchetti: α4β2(∗) nicotinic receptors stimulate GABA release onto fast-spiking cells in layer V of mouse prefrontal (Fr2) cortex. in Neuroscience 2016
the "extra" residue in transmembrane domain 10 of the GABA transporter GAT-1 provides extra bulk, probably in the form of a pi-helix, which is required for stringent gating and tight coupling of ion and substrate fluxes in the GABA transporter family.
Results show that SLC6A1 minor genotypes/alleles were protective against risk for alcoholism in 3 ethnically diverse cohorts.
Genome-wide significant associations were highly biological plausible, including associations within GABA transporter 1, SLC6A1 (solute carrier (show SERTAD2 Antibodies) family 6, member 1), and exonic hits in LOC100129340 (mitofusin-1 (show MFN1 Antibodies)-like
targeted resequencing of 644 individuals with epileptic encephalopathies led to the identification of six SLC6A1 mutations in seven individuals, all of whom have epilepsy with myoclonic-atonic seizures (MAE).
3p25.3 microdeletion of GABA transporters SLC6A1 and SLC6A11 results in intellectual disability, epilepsy and stereotypic behavior.
Cysteine mutagenesis of GAT-1 pointed to conformationally sensitive proximity of extracellular loops 2 and 4 in this protein.
The aromatic and charge pairs of the thin extracellular gate of the GABA transporter GAT-1 are differently impacted by mutation.
a functional interaction of the external and internal gates of GAT-1 is essential for transport
TM10 of GAT-1 lines an accessibility pathway from the extracellular space into the binding pocket and plays a role in the opening and closing of the extracellular transporter gate.
GABA Transporter Mutagenesis Database (GATMD), a web-accessible, relational database of manually annotated biochemical, functional and pharmacological data reported on GAT1.
The SLC6A1 gene encodes a gamma-aminobutyric acid (GABA) transporter, which removes GABA from the synaptic cleft (Hirunsatit et al., 2009
GABA transporter 1
, sodium- and chloride-dependent GABA transporter 1
, solute carrier family 6 (neurotransmitter transporter, GABA), member 1
, solute carrier family 6 member 1
, Betaine/GABA transporter 1
, Na(+)/Cl(-) betaine/GABA transporter
, sodium- and chloride-dependent betaine transporter
, solute carrier family 6 (neurotransmitter transporter, betaine/GABA), member 12
, solute carrier family 6 member 12
, vesicular GABA transporter