anti-GLE1 RNA Export Mediator Homolog (Yeast) (GLE1) Antibodies

GLE1 encodes a predicted 75-kDa polypeptide with high sequence and structure homology to yeast Gle1p, which is nuclear protein with a leucine-rich nuclear export sequence essential for poly(A)+RNA export. Additionally we are shipping GLE1 RNA Export Mediator Homolog (Yeast) Proteins (7) and many more products for this protein.

Gene Name	GeneID	UniProt
GLE1	2733	Q53GS7
GLE1	362098	Q4KLN4
GLE1	74412	Q8R322

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Top anti-GLE1 RNA Export Mediator Homolog (Yeast) Antibodies at antibodies-online.com

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Catalog No.	Reactivity	Host	Conjugate	Application	Quantity	Supplier	Delivery	Price	Details
ABIN2785781	Cow	Rabbit	Un-conjugated	WB	100 μL	Log in to see	2 to 3 Days	$289.00	Details
ABIN2856475	Human	Rabbit	Un-conjugated	ICC, IF, IHC (p), WB	100 μL	Log in to see	3 to 4 Days	$466.18	Details
ABIN322099	Horse	Rabbit	Un-conjugated	WB	50 μg	Log in to see	11 to 14 Days	$551.83	Details
ABIN462552	Human	Rabbit	Un-conjugated	ELISA, IHC, IHC (p), WB	50 μg	Log in to see	11 to 14 Days	$484.00	Details
ABIN462551	Human	Rabbit	Un-conjugated	ELISA, IHC, IHC (p), WB	50 μg	Log in to see	11 to 14 Days	$484.00	Details
ABIN442675	Human	Rabbit	Un-conjugated	ICC, IF, IHC (p), IHC, WB	100 μL	Log in to see	8 to 11 Days	$516.98	Details
ABIN2459776	Human	Rabbit	Un-conjugated	ELISA, WB	50 μg	Log in to see	2 to 3 Days	$446.88	Details
ABIN5554825	Human	Rabbit	Un-conjugated	EIA, IHC (p), WB	0.1 mg	Log in to see	8 to 11 Days	$474.10	Details
ABIN5554826	Human	Rabbit	Un-conjugated	EIA, IHC (p), WB	0.1 mg	Log in to see	8 to 11 Days	$474.10	Details
ABIN1714807	Human	Rabbit	Un-conjugated	IF (p), IHC (p), WB	100 μL	Log in to see	14 to 21 Days	$317.90	Details

More product categories related to GLE1 RNA Export Mediator Homolog (Yeast) Antibody

More Antibodies against GLE1 RNA Export Mediator Homolog (Yeast) Interaction Partners

Human GLE1 RNA Export Mediator Homolog (Yeast) (GLE1) interaction partners

Pathogenic variants in the GLE1 gene are rare in Chinese ALS patients.
Data indicate 2 siblings with a homozygous p.I684T mutation in RNA export mediator (GLE1).
These results imply that DBP5, GLE1 and IP6 have a conserved and individual function in the cytoplasmic mRNA expression. Variations in phenotype are due to the difference in each function of DBP5, GLE1 and IPPK in intracellular mRNA metabolism.
We identified bi-allelic mutations in GLE1 in two unrelated individuals with motor delays, feeding difficulties, and respiratory insufficiency who survived beyond the perinatal period. Each affected child had missense variants predicted to result in amino acid substitutions near the C-terminus of GLE1 that are predicted to disrupt protein-protein interaction or GLE1 protein targeting.
It was concluded that the amyotrophic lateral sclerosis-linked Gle1-c.1965-2A>C mutation generates a protein isoform capable of both Gle1A- and Gle1B-ascribed functions, and thereby uncoupled from normal mechanisms of Gle1 regulation.
We also suggest that lethal congenital contracture syndrome 1 (LCCS1) and lethal arthrogryposis with anterior horn disease (LAAHD), the two AMC subtypes related to GLE1, do not have sufficient clinical or molecular differentiation to be considered allelic disorders. Rather, GLE1 mutations cause a variable spectrum of AMC severity including a non-lethal variant described herein
Restoration of miR-127-3p and miR-376a-3p counteracts the neoplastic phenotype of giant cell tumor of bone derived stromal cells by targeting COA1, GLE1 and PDIA6.
Role for Gle1A during stress granule formation and translation regulation during environmental stress responses is examined.
We report the identification of the first heterozygous mutations in GLE1 ever found to be associated with amyotrophic lateral sclerosis.
Lethal congenital contracture syndrome 1 and lethal arthrogryposis with anterior horn cell disease are associated with defective Gle1 function during the export of mRNA. [review]
Report documents a requirement for Gle1 self-association during mRNA export and uncover molecular defects underlying a lethal human disease lethal congenital contracture syndrome-1.
Dbp5, Gle1-IP6 and Nup159: a working model for mRNP export.
defective zebrafish GLE1 function in human LCCS1 results in both neurogenic and non-neurogenic defects linked to the apoptosis of proliferative organ precursors
The unique carboxyl-terminal 43 amino acid region of the hGle1B isoform mediates binding to the C-terminal non-phenylalanine- glycine region of the nucleoporin hCG1/NPL1.
Mutations in mRNA export mediator GLE1 result in fetal motoneuron disease.

GLE1 RNA Export Mediator Homolog (Yeast) (GLE1) Antigen Profile

Protein Summary

This gene encodes a predicted 75-kDa polypeptide with high sequence and structure homology to yeast Gle1p, which is nuclear protein with a leucine-rich nuclear export sequence essential for poly(A)+RNA export. Inhibition of human GLE1L by microinjection of antibodies against GLE1L in HeLa cells resulted in inhibition of poly(A)+RNA export. Immunoflourescence studies show that GLE1L is localized at the nuclear pore complexes. This localization suggests that GLE1L may act at a terminal step in the export of mature RNA messages to the cytoplasm. Two alternatively spliced transcript variants encoding different isoforms have been found for this gene.

Gene names and symbols associated with GLE1

CG14749 gene product from transcript CG14749-RA (CG14749) antibody
nucleoporin GLE1 (CpipJ_CPIJ014147) antibody
RNA export factor Gle1 (SJAG_03847) antibody
GLE1, RNA export mediator (GLE1) antibody
GLE1 RNA export mediator (Gle1) antibody
GLE1 RNA export mediator (yeast) (Gle1) antibody

4933405K21Rik antibody
AA553313 antibody
Dmel\\CG14749 antibody
GLE1 antibody
Gle1l antibody
hGLE1 antibody
LCCS antibody
LCCS1 antibody

Protein level used designations for GLE1

CG14749-PA , nucleoporin GLE1 , GLE1 RNA export mediator homolog , GLE1-like protein , GLE1-like, RNA export mediator , GLE1 RNA export mediator-like (yeast

GENE ID	SPECIES
35849	Drosophila melanogaster
6047573	Culex quinquefasciatus
7050485	Schizosaccharomyces japonicus yFS275
417212	Gallus gallus
2733	Homo sapiens
362098	Rattus norvegicus
74412	Mus musculus
480704	Canis lupus familiaris
540982	Bos taurus
100172586	Pongo abelii

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