GLE1 antibody (C-Term)

Catalog No. ABIN499892

The Rabbit Polyclonal anti-GLE1 antibody is suitable to detect GLE1 in samples from Human, Rat and Mouse. It has been validated for WB, IHC (p) and EIA.

Quick Overview for GLE1 antibody (C-Term) (ABIN499892)

Target: GLE1 (GLE1 RNA Export Mediator (GLE1))

Reactivity: Human, Rat, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This GLE1 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)

Product Details anti-GLE1 Antibody

Binding Specificity: C-Term

Specificity: This antibody reacts to GLE1.

Purification: Affinity chromatography purified via peptide column

Immunogen: Gle1 antibody was raised against a 15 amino acid peptide near the carboxy terminus of human Gle1.

Isotype: IgG

Application Details

Application Notes: ELISA. Western Blot: 1 - 2 μg/mL. Immunohistochemistry.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Handling

Buffer: PBS containing 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C

Storage Comment: Store the antibody undiluted at 2-8 °C.

Target Details for GLE1

Target: GLE1 (GLE1 RNA Export Mediator (GLE1))

Alternative Name: GLE1 / GLE1L

Background: The proper expression of gene products in eukaryotic cells relies on efficient transport of mRNA molecules out of the nucleus. Gle1 is an essential mRNA export factor in both human and yeast cells. It associates with the nuclear pore complex (NPC) through hCG1 and NUP155 in mammalian cells and in conjunction with inositol hexakisphosphate (IP6), stimulates Dbp5, a member of the DEAD-box helicase family, triggering mRNP remodeling and facilitating RNA export from the nucleus. Recent evidence suggests that mutations in Gle1 causing defects in mRNA export can result in human disease. At least three isoforms of Gle1 are known to exist.Synonyms: GLE1-like protein, Nucleoporin GLE1

Gene ID: 2733

NCBI Accession: NP_001003722

UniProt: Q53GS7