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GRASP encodes a protein that functions as a molecular scaffold, linking receptors, including group 1 metabotropic glutamate receptors, to neuronal proteins.
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Mouse (Murine) Polyclonal GRASP Primary Antibody for IP, ELISA - ABIN233820
Kitano, Kimura, Yamazaki, Soda, Shigemoto, Nakajima, Nakanishi: Tamalin, a PDZ domain-containing protein, links a protein complex formation of group 1 metabotropic glutamate receptors and the guanine nucleotide exchange factor cytohesins. in The Journal of neuroscience : the official journal of the Society for Neuroscience 2002
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Study results indicate a potential role of Grasp in the p53 (show TP53 Antibodies)-mediated response of skin to UVB exposure
A major mechanism by which insulin (show INS Antibodies) regulates glut4 (show SLC2A4 Antibodies) recycling was uncovered. A general receptor for 3-phosphoinositides 1 was identified as a guanine nucleotide exchange factor for ADP-ribosylation factor 6 (show PSD3 Antibodies) that promotes glut4 (show SLC2A4 Antibodies) vesicle formation.
An upregulation of scaffold protein (show HOMER1 Antibodies) tamalin is found selectively in the hippocampus of animals subjected to electroconvulsive shock.
Caspase (show CASP3 Antibodies) cleavage of GRASP-1 (show GRIPAP1 Antibodies) occurs in specific brain regions in a time-dependent manner during development and ischemia.
tamalin is a novel signaling molecule that possesses a PDZ domain (show INADL Antibodies) and a PDZ (show INADL Antibodies) binding motif and mediates Syk (show SYK Antibodies) signaling in an ITAM-based fashion
plays a role in metabotropic glutamate (show GRIN1 Antibodies) receptor transport and forms its autoinhibitory state.[review]
Schizophrenia subjects compared to controls showed a marked increase in CA1 (show CA1 Antibodies) hippocampal Norbin (show NCDN Antibodies), and Tamalin proteins (47% and 34% respectively), which are endogenous regulators of mGluR5 (show GRM5 Antibodies) signalling and trafficking
GRASP bridges the guanine nucleotide exchange factors (GEFs) that activate Arf and Rac (show AKT1 Antibodies), thereby promoting Arf-to-Rac (show AKT1 Antibodies) signaling By binding to both cytohesin 2/ARNO (show CYTH2 Antibodies) and Dock180 (show DOCK1 Antibodies).
GRASP regulates the non-clathrin/Arf6 (show ARF6 Antibodies)-dependent, plasma membrane recycling and signalling pathways.
protein-protein interaction mediated by ARNO (show CYTH2 Antibodies) coiled-coil domain required for ARNO (show CYTH2 Antibodies) induced motility; coiled-coil domain promotes assembly of multiprotein complex containing ARNO (show CYTH2 Antibodies) and Dock180 (show DOCK1 Antibodies); assembly of complex requires coiled-coil domain, GRASP and IPCEF
The crystal structures of the autoinhibitory PDZ domain (show INADL Antibodies) of Tamalin has implications for the regulation of metabotropic glutamate (show GRIN1 Antibodies) receptor trafficking.
This gene encodes a protein that functions as a molecular scaffold, linking receptors, including group 1 metabotropic glutamate receptors, to neuronal proteins. The encoded protein contains conserved domains, including a leucine zipper sequence, PDZ domain and a C-terminal PDZ-binding motif. Alternately spliced transcript variants have been observed for this gene.
general receptor for phosphoinositides 1-associated scaffold protein
, GRP1 (general receptor for phosphoinositides 1)-associated scaffold protein
, GRP1-associated scaffold protein
, 95 kDa postsynaptic density protein discs-large ZO-1 domain-containing protein
, Grp1 (general receptor for phosphoinositides)-associated scaffold protein
, PSD-95 PDZ domain-containing protein