anti-GRP1 (General Receptor For phosphoinositides 1)-Associated Scaffold Protein (GRASP) Antibodies

Mouse (Murine) GRP1 (General Receptor For phosphoinositides 1)-Associated Scaffold Protein (GRASP) interaction partners

1. Study results indicate a potential role of Grasp in the p53-mediated response of skin to UVB exposure

2. A major mechanism by which insulin regulates glut4 recycling was uncovered. A general receptor for 3-phosphoinositides 1 was identified as a guanine nucleotide exchange factor for ADP-ribosylation factor 6 that promotes glut4 vesicle formation.

3. An upregulation of scaffold protein tamalin is found selectively in the hippocampus of animals subjected to electroconvulsive shock.

4. Caspase cleavage of GRASP-1 occurs in specific brain regions in a time-dependent manner during development and ischemia.

5. tamalin is a novel signaling molecule that possesses a PDZ domain and a PDZ binding motif and mediates Syk signaling in an ITAM-based fashion

6. plays a role in metabotropic glutamate receptor transport and forms its autoinhibitory state.[review]

Human GRP1 (General Receptor For phosphoinositides 1)-Associated Scaffold Protein (GRASP) interaction partners

1. Schizophrenia subjects compared to controls showed a marked increase in CA1 hippocampal Norbin, and Tamalin proteins (47% and 34% respectively), which are endogenous regulators of mGluR5 signalling and trafficking

2. myristoylated GRASP promoted tethering and exhibited a unique membrane complex. Thus, myristoylation restricts the membrane orientation of the GRASP domain favoring interactions in trans for membrane tethering.

3. GRASP bridges the guanine nucleotide exchange factors (GEFs) that activate Arf and Rac, thereby promoting Arf-to-Rac signaling By binding to both cytohesin 2/ARNO and Dock180.

4. GRASP regulates the non-clathrin/Arf6-dependent, plasma membrane recycling and signalling pathways.

5. the structural basis of the phosphoinhibition of GRASP-mediated membrane tethering and provide a mechanism for its allosteric regulation.

6. protein-protein interaction mediated by ARNO coiled-coil domain required for ARNO induced motility; coiled-coil domain promotes assembly of multiprotein complex containing ARNO and Dock180; assembly of complex requires coiled-coil domain, GRASP and IPCEF

7. The crystal structures of the autoinhibitory PDZ domain of Tamalin has implications for the regulation of metabotropic glutamate receptor trafficking.