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anti-GTPase Activating Protein (SH3 Domain) Binding Protein 1 (G3BP1) Antibodies

G3BP1 encodes one of the DNA-unwinding enzymes which prefers partially unwound 3'-tailed substrates and can also unwind partial RNA/DNA and RNA/RNA duplexes in an ATP-dependent fashion. Additionally we are shipping GTPase Activating Protein (SH3 Domain) Binding Protein 1 Proteins (12) and GTPase Activating Protein (SH3 Domain) Binding Protein 1 Kits (7) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
G3BP1 10146 Q13283
G3BP1 171092  
G3BP1 27041 P97855
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Top anti-GTPase Activating Protein (SH3 Domain) Binding Protein 1 Antibodies at antibodies-online.com

Showing 10 out of 148 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Cow Rabbit Un-conjugated IHC, IP, WB <b>WB Suggested Anti-G3BP1 Antibody Titration: </b>0.2-1 ug/ml<br><b>ELISA Titer: </b>1:312500<br><b>Positive Control: </b>HT1080 cell lysate <b>IP Suggested Anti-G3BP1 Antibody </b><br><b>Positive Control: </b>NT2 CELL/BRAIN TISSUE 100 μL Log in to see 2 to 3 Days
$289.00
Details
Cow Rabbit Un-conjugated WB Host: Rabbit <br /> Target Name: G3BP <br /> Sample Tissue: HepG2Lane A: Primary Antibody Lane B: Primary Antibody + Blocking Peptide <br />Primary Antibody Concentration: 2.5 µg/mL Peptide Concentration:..0 µg/mL Lysate Quantity:.41 µg/laneGel Concentration: 12 % 100 μL Log in to see 2 to 3 Days
$229.00
Details
Human Rabbit Un-conjugated IHC (p), WB G3BP1 Antibody (C-term) (ABIN657707) western blot analysis in Jurkat cell line lysates (35 µg/lane). This demonstrates the G3BP1 antibody detected the G3BP1 protein (arrow). 400 μL Log in to see 10 to 11 Days
$324.50
Details
Human Rabbit Un-conjugated IC, IF, IHC, WB Immunofluorescent analysis of G3BP1 staining in A549 cells. Formalin-fixed cells were permeabilized with 0.1% Triton X-100 in TBS for 5-10 minutes and blocked with 3% BSA-PBS for 30 minutes at room temperature. Cells were probed with the primary antibody in 3% BSA-PBS and incubated overnight at 4 °C in a humidified chamber. Cells were washed with PBST and incubated with a DyLight 594-conjugated secondary antibody (red) in PBS at room temperature in the dark. DAPI was used to stain the cell nuclei (blue). Immunohistochemical analysis of G3BP1 staining in human breast cancer formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with the antibody at room temperature and detected using an HRP conjugated compact polymer system. DAB was used as the chromogen. The section was then counterstained with haematoxylin and mounted with DPX. 200 μL Log in to see 13 to 14 Days
$487.50
Details
Human Rabbit Un-conjugated IC, IF, IHC, WB Immunofluorescent analysis of G3BP1 (pS232) staining in A549 cells. Formalin-fixed cells were permeabilized with 0.1% Triton X-100 in TBS for 5-10 minutes and blocked with 3% BSA-PBS for 30 minutes at room temperature. Cells were probed with the primary antibody in 3% BSA-PBS and incubated overnight at 4 °C in a humidified chamber. Cells were washed with PBST and incubated with a DyLight 594-conjugated secondary antibody (red) in PBS at room temperature in the dark. DAPI was used to stain the cell nuclei (blue). Immunohistochemical analysis of G3BP1 (pS232) staining in human breast cancer formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with the antibody at room temperature and detected using an HRP conjugated compact polymer system. DAB was used as the chromogen. The section was then counterstained with haematoxylin and mounted with DPX. 200 μL Log in to see 13 to 14 Days
$575.00
Details
Human Mouse Un-conjugated IF, WB Immunofluorescence of monoclonal antibody to G3BP on HeLa cell (antibody concentration 10 µg/mL). Western blot analysis of G3BP over-expressed 293 cell line, cotransfected with G3BP Validated Chimera RNAi used as specificity and loading control. 0.1 mg Log in to see 8 to 11 Days
$450.00
Details
Cow Rabbit Un-conjugated WB 100 μL Log in to see 2 to 3 Days
$289.00
Details
Human Rabbit Un-conjugated IHC, ELISA, WB Western blot analysis of extracts from HeLa cells, using G3BP-1 (Ab-232) Antibody. The lane on the right is treated with the synthesized peptide. Immunohistochemistry analysis of paraffin-embedded human breast carcinoma tissue, using G3BP-1 (Ab-232) Antibody. The picture on the right is treated with the synthesized peptide. 100 μg Log in to see 2 to 3 Days
$302.50
Details
Human Rabbit Un-conjugated IHC, ELISA, WB Western blot analysis of extracts from HeLa cells, using G3BP-1 (Phospho-Ser232) Antibody. The lane on the right is treated with the synthesized peptide. Immunohistochemistry analysis of paraffin-embedded human breast carcinoma, using G3BP-1 (Phospho-Ser232) Antibody. The picture on the right is treated with the synthesized peptide. 100 μg Log in to see 2 to 3 Days
$302.50
Details
Human Mouse Un-conjugated IF, WB Western blot analysis of G3BP on a SW-13 cell lysate (Human adrenal gland carcinoma, ATCC CCL-105) . Lane 1: 1:1000, lane 2: 1:2000, lane 3: 1:4000 dilution of the mouse anti-human G3BP antibody. G3BP may be observed migrating in a range of 55-70 kDa. Immunofluorescence staining of A431 cells (Human epithelial carcinoma, ATCC CRL-1555). 150 μg Log in to see 6 to 8 Days
$305.54
Details

G3BP1 Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality Conjugate
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Rat (Rattus)
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Mouse (Murine)
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Top referenced anti-GTPase Activating Protein (SH3 Domain) Binding Protein 1 Antibodies

  1. Human Monoclonal G3BP1 Primary Antibody for IF, IHC (p) - ABIN564390 : Norazit, Meedeniya, Nguyen, Mackay-Sim: Progressive loss of dopaminergic neurons induced by unilateral rotenone infusion into the medial forebrain bundle. in Brain research 2010 (PubMed)
    Show all 4 Pubmed References

  2. Human G3BP1 Primary Antibody for IHC - ABIN966168 : Tao, Wollscheid, OBrien, Eng, Li, Bodenmiller, Watts, Hood, Aebersold: Quantitative phosphoproteome analysis using a dendrimer conjugation chemistry and tandem mass spectrometry. in Nature methods 2005 (PubMed)
    Show all 5 Pubmed References

  3. Human Monoclonal G3BP1 Primary Antibody for IF, WB - ABIN968381 : Gallouzi, Parker, Chebli, Maurier, Labourier, Barlat, Capony, Tocque, Tazi: A novel phosphorylation-dependent RNase activity of GAP-SH3 binding protein: a potential link between signal transduction and RNA stability. in Molecular and cellular biology 1998 (PubMed)
    Show all 2 Pubmed References

  4. Cow (Bovine) Polyclonal G3BP1 Primary Antibody for WB - ABIN2780221 : Kociok, Esser, Unfried, Parker, Schraermeyer, Grisanti, Toqué, Heimann: Upregulation of the RAS-GTPase activating protein (GAP)-binding protein (G3BP) in proliferating RPE cells. in Journal of cellular biochemistry 1999 (PubMed)
    Show all 3 Pubmed References

  5. Human Monoclonal G3BP1 Primary Antibody for IF, WB - ABIN968380 : Parker, Maurier, Delumeau, Duchesne, Faucher, Debussche, Dugue, Schweighoffer, Tocque: A Ras-GTPase-activating protein SH3-domain-binding protein. in Molecular and cellular biology 1996 (PubMed)
    Show all 2 Pubmed References

  6. Human Polyclonal G3BP1 Primary Antibody for IP, PLA - ABIN438758 : Fujimura, Sasaki, Anderson: Selenite targets eIF4E-binding protein-1 to inhibit translation initiation and induce the assembly of non-canonical stress granules. in Nucleic acids research 2012 (PubMed)
    Show all 2 Pubmed References

  7. Human Polyclonal G3BP1 Primary Antibody for ICC, IF - ABIN4313041 : Martin, Bellora, González-Vallinas, Irimia, Chebli, de Toledo, Raabe, Eyras, Urlaub, Blencowe, Tazi: Preferential binding of a stable G3BP ribonucleoprotein complex to intron-retaining transcripts in mouse brain and modulation of their expression in the cerebellum. in Journal of neurochemistry 2016 (PubMed)

  8. Human Polyclonal G3BP1 Primary Antibody for IF (p), IHC (p) - ABIN801153 : Luo, Fang, Jin, Wang, An, Xu, Chen, Xiao: Label-free quantitative phosphoproteomic analysis reveals differentially regulated proteins and pathway in PRRSV-infected pulmonary alveolar macrophages. in Journal of proteome research 2014 (PubMed)

  9. Human Polyclonal G3BP1 Primary Antibody for IHC - ABIN966169 : Beausoleil, Jedrychowski, Schwartz, Elias, Villén, Li, Cohn, Cantley, Gygi: Large-scale characterization of HeLa cell nuclear phosphoproteins. in Proceedings of the National Academy of Sciences of the United States of America 2004 (PubMed)
    Show all 3 Pubmed References

  10. Human Polyclonal G3BP1 Primary Antibody for IF, WB - ABIN523522 : Kaehler, Isensee, Nonhoff, Terrey, Hucho, Lehrach, Krobitsch: Ataxin-2-like is a regulator of stress granules and processing bodies. in PLoS ONE 2012 (PubMed)

More Antibodies against GTPase Activating Protein (SH3 Domain) Binding Protein 1 Interaction Partners

Human GTPase Activating Protein (SH3 Domain) Binding Protein 1 (G3BP1) interaction partners

  1. Activated glucocorticoid receptor (show NR3C1 Antibodies) induced phosphorylation of v-AKT (show AKT1 Antibodies) Murine Thymoma Viral Oncogene (show RAB1A Antibodies) Homologue (AKT (show AKT1 Antibodies)) kinase, which in turn phosphorylated and promoted nuclear translocation of G3BP1. The nuclear G3BP1 bound to the G3BP1 consensus sequence located on primary miR (show MLXIP Antibodies)-15b~16-2 and miR (show MLXIP Antibodies)-23a~27a~24-2 to inhibit their maturation.

  2. Results show the crystal structure of the NTF2 (show NUTF2 Antibodies)-like domain of G3BP-1 in complex with nsP3 (show SH2D3C Antibodies) protein revealing a poly-complex of G3BP-1 dimers interconnected through the FGDF motifs in nsP3 (show SH2D3C Antibodies). Although in vitro and in vivo binding studies revealed a hierarchical interaction of the two FGDF motifs with G3BP-1, viral growth curves clearly demonstrated that two intact FGDF motifs are required for efficient viral replication.

  3. Based on insights from the structures and existing biochemical data, the existence of an evolutionarily conserved ribonucleoprotein (RNP (show RNPC3 Antibodies)) complex consisting of Caprin-1, FMRP (show FMR1 Antibodies) and G3BP1 is proposed.

  4. G3BP1 interacts directly with the foot-and-mouth disease virus internal ribosome entry site and negatively regulates translation.

  5. The data suggested that JNK (show MAPK8 Antibodies)-enhanced Tudor-SN phosphorylation promotes the interaction between Tudor-SN and G3BP and facilitates the efficient recruitment of Tudor-SN into stress granules under conditions of sodium arsenite-induced oxidative stress.

  6. These data support a role for casein kinase 2 in regulation of protein synthesis by downregulating stress granule formation through G3BP1.

  7. G3BP1 is differentially methylated on specific arginine residues by protein arginine methyltransferase (show PRMT1 Antibodies) (PRMT) 1 (show PRMT1 Antibodies) and PRMT5 (show PRMT5 Antibodies) in its RGG domain.

  8. Our data define G3BP1 as a novel independent prognostic factor that is correlated with gastric cancer progression.

  9. G3BP mediates the condensation of stress granules by shifting between two different states that are controlled by the phosphorylation of S149 and by binding to Caprin1 or USP10 (show USP10 Antibodies).

  10. Host G3BP1 captures HIV-1 RNA transcripts and thereby restricts mRNA translation, viral protein production and virus particle formation.

Mouse (Murine) GTPase Activating Protein (SH3 Domain) Binding Protein 1 (G3BP1) interaction partners

  1. the aberrant mutant SOD1 (show SOD1 Antibodies)-G3BP1 interaction affects stress granule dynamics

  2. G3BP is involved in a new functional mechanism to regulate non-coding RNAs including intron-retaining transcripts, and thus have broad implications for neuronal gene regulation, where intron retention is widespread

  3. G3bp1 posttranscriptionally regulates miRNA-1 processing in the heart.

  4. Our findings identified a novel function of G3BP1 in the progression of breast cancer via activation of the epithelial-to-mesenchymal transition

  5. Cytoplasmic granule containing HERMES (show CD44 Antibodies), NonO (show NONO Antibodies), PSF (show IL-3 Antibodies), and G3BP1 is a neuronal RNA-protein granule that is transported in neurites during retinal differentiation.

  6. These results show, for the first time, a requirement for G3BP1 in the control of neuronal plasticity and calcium homeostasis

  7. Data show that protein kinase (show CDK7 Antibodies) R as the principal kinase that mediates eukaryotic initiation factor 2alpha (eIF2alpha (show EIF2S1 Antibodies)) phosphorylation by large RasGAP (show RASA1 Antibodies) SH3-binding protein (show SH3BP5 Antibodies) (G3BP)-induced granules.

  8. arguments against G3BP1 being a genuine RasGAP (show RASA1 Antibodies)-binding partner

  9. G3BP1 is a novel Ctnnb1 (show CTNNB1 Antibodies) mRNA binding protein. Methylation of G3BP1 constitutes a molecular switch that regulates Ctnnb1 (show CTNNB1 Antibodies) mRNA in response to Wnt3a (show WNT3A Antibodies).

  10. IMP-1 (show IMPA1 Antibodies) associates with HuD (show ELAVL4 Antibodies) and G3BP-1 proteins in an RNA-dependent manner and binds directly to tau mRNA. We also show an RNA-dependent association between G3BP-1 and HuD (show ELAVL4 Antibodies) proteins

Pig (Porcine) GTPase Activating Protein (SH3 Domain) Binding Protein 1 (G3BP1) interaction partners

  1. It has been demonstrated a depletion of G3BP1 and TIA-1/TIAR in senescent cells and it was shown that the loss of G3BP1 contributed to impaired stress granules formation.

GTPase Activating Protein (SH3 Domain) Binding Protein 1 (G3BP1) Antigen Profile

Protein Summary

This gene encodes one of the DNA-unwinding enzymes which prefers partially unwound 3'-tailed substrates and can also unwind partial RNA/DNA and RNA/RNA duplexes in an ATP-dependent fashion. This enzyme is a member of the heterogeneous nuclear RNA-binding proteins and is also an element of the Ras signal transduction pathway. It binds specifically to the Ras-GTPase-activating protein by associating with its SH3 domain. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been determined.

Gene names and symbols associated with G3BP1

  • G3BP stress granule assembly factor 1 (G3BP1) antibody
  • GTPase activating protein (SH3 domain) binding protein 1 (g3bp1) antibody
  • GTPase activating protein (SH3 domain) binding protein 1 L homeolog (g3bp1.L) antibody
  • Ras-GTPase-activating protein SH3-domain-binding protein (LOC100304885) antibody
  • G3BP stress granule assembly factor 1 (G3bp1) antibody
  • GTPase activating protein (SH3 domain) binding protein 1 (G3bp1) antibody
  • AI849976 antibody
  • B430204O07 antibody
  • C87777 antibody
  • fj17h05 antibody
  • G3bp antibody
  • G3BP1 antibody
  • HDH-VIII antibody
  • MGC53271 antibody
  • mKIAA4115 antibody
  • RGD1310666 antibody
  • wu:fj17h05 antibody
  • zgc:56034 antibody

Protein level used designations for G3BP1

ATP-dependent DNA helicase VIII , G3BP-1 , GAP SH3 domain-binding protein 1 , GAP binding protein , Ras-GTPase-activating protein SH3-domain-binding protein , RasGAP-associated endoribonuclease G3BP , ras GTPase-activating protein-binding protein 1 , GTPase activating protein (SH3 domain) binding protein 1 , ATP-dependent DNA/RNA helicase G3BP , Ras-GTPase-activating protein SH3-domain binding protein 1 , GAP SH3 binding protein , HDH-VIII

GENE ID SPECIES
10146 Homo sapiens
335512 Danio rerio
380390 Xenopus laevis
471711 Pan troglodytes
534214 Bos taurus
713884 Macaca mulatta
100304885 Ictalurus punctatus
171092 Rattus norvegicus
27041 Mus musculus
479322 Canis lupus familiaris
100513766 Sus scrofa
100172476 Pongo abelii
100725714 Cavia porcellus
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