General Transcription Factor III Proteins (GTF2I)

The protein encoded by GTF2I contains five GTF2I-like repeats and each repeat possesses a potential helix-loop-helix (HLH) motif. Additionally we are shipping GTF2I Antibodies (115) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
GTF2I 2969 P78347
Rat GTF2I GTF2I 353256 Q5U2Y1
GTF2I 14886 Q9ESZ8
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Top GTF2I Proteins at

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Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 70 Days
Insect Cells Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 70 Days
Wheat germ Human GST tag 2 μg Log in to see 11 to 12 Days

GTF2I Proteins by Origin and Source

Origin Expressed in Conjugate
Human ,
Mouse (Murine)

More Proteins for General Transcription Factor III (GTF2I) Interaction Partners

Human General Transcription Factor III (GTF2I) interaction partners

  1. demonstrate a marked prevalence of a thymoma-specific mutated oncogene, GTF2I

  2. we identified largest-ever effect on Asian rheumatoid arthritis across human non-HLA regions at GTF2I by heterogeneity mapping followed by replication studies, and pinpointed a possible causal variant

  3. the frequency of GTF2I mutation is higher in more indolent TETs and correlated with better prognosis.

  4. GTF2I/Gtf2i, its physiologic role in human disorders was relatively unknown until recently. Novel studies show that it is involved in an array of human diseases including neurocognitive disorders, systemic lupus erythematosus (SLE), and cancer.

  5. the results reported here support a model whereby common genetic variation in GTF2I mediates human sociality and anxiety via effects on oxytocin reactivity.

  6. GTF2I mutations common in thymic epithelial tumors are not present/uncommon in hematological malignancies.

  7. a new BRAF fusion in pilocytic astrocytoma

  8. A common polymorphism in the Williams syndrome gene GTF2I associated with reduced social anxiety predicts decreased threat-related amygdala reactivity, which mediates an association between genotype and increased warmth in women.

  9. We identified rs117026326 on GTF2I with GWAS significance (P = 1.10 x 10(-15)) and rs13079920 on RBMS3 with suggestive significance (P = 2.90 x 10(-5)) associating with Primary Sjogren's syndrome in women.

  10. The authors found that human adenovirus 5 infection or ectopic E4-ORF3 expression leads to SUMOylation of TFII-I that precedes a rapid decline in TFII-I protein levels.

  11. A novel interaction between TFII-I and Mdm2 with a negative effect on TFII-I transcriptional activity has been documented.

  12. Copy-number variation in the general transcription factor gene, GTF2I is associated with gene-dose-dependent anxiety in mouse models and in both Williams syndrome and Dup7.

  13. show that SUMOylation is critical for TFII-I to promote cell proliferation and colony formation. Our findings contribute to understanding the role of SUMOylation in liver cancer development

  14. Study demonstrates a significant association between SLE in Chinese Han population and the GTF2I rs117026326 T allele/GTF2IRD1 rs4717901 C allele.

  15. Rather than contributing positively to promoter activity, a putative initiator element at the transcription start site acts as a target for negative regulation imposed on the L4P promoter of human adenovirus Type 5 by cellular TFII-I.

  16. Findings implicate the GTF2I gene in the neurogenetic basis of social communication and social anxiety, both in Williams syndrome and among individuals in healthy populations

  17. TFII-I bridges Proliferating Cell Nuclear Antigen and Polzeta to promote Translesion synthesis

  18. The GTF2I rs117026326 polymorphism is associated with anti-SSA-positive primary Sjogren's syndrome.

  19. A proportion of this transcriptional dysregulation is caused by dosage imbalances in GTF2I, which encodes a key transcription factor at 7q11.23 that is associated with the LSD1 repressive chromatin complex and silences its dosage-sensitive targets.

  20. GTF2I mutation correlated with better survival.

Mouse (Murine) General Transcription Factor III (GTF2I) interaction partners

  1. The results suggest a role for GTF2i in the hypersocial phenotype of WBS and more broadly in the regulation of social behavior. Support was not observed for the role of GTF2i in ASD.

  2. The Cre-mediated deletion of exon 3 recapitulates a genetic null phenotype, indicating that the conditional Gtf2i line is a valuable tool for studying TFII-I function during embryonic development

  3. found a highly conserved DNA element, common to a set of genes regulated by TFII-I, and identified and validated novel in vivo neuronal targets of this protein affecting the PI3K and TGFbeta signaling pathways

  4. GTF2IRD2 has evolved as a regulator of GTF2IRD1 and TFII-I; inhibiting their function by direct interaction and sequestration into inactive nuclear zones.

  5. data support the hypothesis that upregulation of TFII-I factors leads to activation of a specific group of developmental genes during mESC differentiation

  6. GTF2I duplication results in separation anxiety in mice and humans

  7. In order to clarify the involvement of GTF2I in neurocognitive function, especially social behavior, we have developed and characterized Gtf2i-deficient mice.

  8. Results suggest that DJ-1 together with TFII-I operate in concert to cope with various insults and to sustain pancreatic beta-cell function.

  9. behavioral characterization of heterozygous mice with a deletion of the first 140 amino-acids of TFII-I.

  10. data demonstrate that TFII-I, through a Src-dependent mechanism, reversibly translocates from the cytoplasm to the nucleus, leading to the transcriptional activation of growth-regulated genes

  11. acts as a transcriptional cofactor for the SUMO ubiquitin-protein isopeptide ligase family member Miz1/PIASxbeta /Siz2

  12. TFII-I has a role in regulating immunoglobulin promoter activity

  13. TFII-I, involved in histone modification and SUMOylation, is expressed at early stages of embryogenesis.

  14. TFII-I is required for optimal induction of Grp78 by ER stress

  15. TFII-I has a role in the regulation of the Gsc gene in response to a TGFbeta/activin signal

  16. a unique growth factor signaling pathway is controlled by opposing activities of two TFII-I spliced isoforms

  17. The three-dimensional structure of the GTF2I domain is classified as a new fold, consisting of four helices, two antiparallel beta strands, and a well-defined loop containing two beta-turns between sheet 1 and helix 3.

  18. Gtf2i showed widespread expression in the developing head but was higher in the developing teeth than surrounding tissues throughout tooth development

  19. Bioinformatics and microarray results were combined to identify TFII-I downstream targets in the vertebrate genome.

  20. homozygous loss of Gtf2ird1 or Gtf2i results in multiple phenotypic manifestations, including embryonic lethality; brain hemorrhage; and vasculogenic, craniofacial, and neural tube defects; defects in yolk sac vasculogenesis and angiogenesis

GTF2I Protein Profile

Protein Summary

This gene encodes a multifunctional phosphoprotein with roles in transcription and signal transduction. It is deleted in Williams-Beuren syndrome, a multisystem developmental disorder caused by the deletion of contiguous genes at chromosome 7q11.23. Alternative splicing results in multiple transcript variants. Related pseudogenes have been identified on chromosomes 7, 13 and 21.

Gene names and symbols associated with GTF2I

  • general transcription factor IIi (GTF2I)
  • general transcription factor II I (Gtf2i)
  • general transcription factor IIi (gtf2i)
  • general transcription factor IIi (Gtf2i)
  • general transcription factor IIi S homeolog (gtf2i.S)
  • 6030441I21Rik protein
  • bap-135 protein
  • bap135 protein
  • btkap1 protein
  • diws protein
  • gtf2i protein
  • gtf2i.L protein
  • Gtf2ird1 protein
  • gtfii-i protein
  • ib291 protein
  • spin protein
  • tfii-i protein
  • wbs protein
  • wbscr6 protein

Protein level used designations for GTF2I

BTK-associated protein, 135kD , Bruton tyrosine kinase-associated protein 135 , SRF-Phox1-interacting protein , Williams-Beuren syndrome chromosome region 6 , general transcription factor II-I , GTFII-I , TFII-I , BTK-associated protein 135 , general transcription factor II, i , general transcription factor IIi L homeolog , general transcription factor IIi S homeolog

2969 Homo sapiens
353256 Rattus norvegicus
14886 Mus musculus
534669 Bos taurus
549986 Xenopus (Silurana) tropicalis
417486 Gallus gallus
479714 Canis lupus familiaris
100724513 Cavia porcellus
443780 Xenopus laevis
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