General Transcription Factor III Proteins (GTF2I)

GTF2I encodes a multifunctional phosphoprotein with roles in transcription and signal transduction. Additionally we are shipping GTF2I Antibodies (125) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
GTF2I 2969 P78347
Rat GTF2I GTF2I 353256 Q5U2Y1
GTF2I 14886 Q9ESZ8
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Top GTF2I Proteins at

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Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 70 Days
Insect Cells Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 70 Days
Wheat germ Human GST tag 2 μg Log in to see 11 to 12 Days

GTF2I Proteins by Origin and Source

Origin Expressed in Conjugate
Human ,
Mouse (Murine)

More Proteins for General Transcription Factor III (GTF2I) Interaction Partners

Human General Transcription Factor III (GTF2I) interaction partners

  1. GTF2I mutations common in thymic epithelial tumors are not present/uncommon in hematological malignancies.

  2. a new BRAF (show BRAF Proteins) fusion in pilocytic astrocytoma

  3. A common polymorphism in the Williams syndrome gene GTF2I associated with reduced social anxiety predicts decreased threat-related amygdala reactivity, which mediates an association between genotype and increased warmth in women.

  4. We identified rs117026326 on GTF2I with GWAS significance (P = 1.10 x 10(-15)) and rs13079920 on RBMS3 (show RBMS3 Proteins) with suggestive significance (P = 2.90 x 10(-5)) associating with Primary Sjogren's syndrome in women.

  5. The authors found that human adenovirus 5 infection or ectopic E4-ORF3 expression leads to SUMOylation of TFII-I that precedes a rapid decline in TFII-I protein levels.

  6. A novel interaction between TFII-I and Mdm2 (show MDM2 Proteins) with a negative effect on TFII-I transcriptional activity has been documented.

  7. Copy-number variation in the general transcription factor gene, GTF2I is associated with gene-dose-dependent anxiety in mouse models and in both Williams syndrome and Dup7.

  8. show that SUMOylation is critical for TFII-I to promote cell proliferation and colony formation. Our findings contribute to understanding the role of SUMOylation in liver cancer development

  9. Study demonstrates a significant association between SLE in Chinese Han population and the GTF2I rs117026326 T allele/GTF2IRD1 rs4717901 C allele.

  10. Rather than contributing positively to promoter activity, a putative initiator element at the transcription start site acts as a target for negative regulation imposed on the L4P promoter of human adenovirus Type 5 by cellular TFII-I.

Mouse (Murine) General Transcription Factor III (GTF2I) interaction partners

  1. The Cre-mediated deletion of exon 3 recapitulates a genetic null phenotype, indicating that the conditional Gtf2i line is a valuable tool for studying TFII-I function during embryonic development

  2. found a highly conserved DNA element, common to a set of genes regulated by TFII-I, and identified and validated novel in vivo neuronal targets of this protein affecting the PI3K and TGFbeta (show TGFB1 Proteins) signaling pathways

  3. GTF2IRD2 (show GTF2IRD2 Proteins) has evolved as a regulator of GTF2IRD1 and TFII-I; inhibiting their function by direct interaction and sequestration into inactive nuclear zones.

  4. data support the hypothesis that upregulation of TFII-I factors leads to activation of a specific group of developmental genes during mESC differentiation

  5. GTF2I duplication results in separation anxiety in mice and humans

  6. In order to clarify the involvement of GTF2I in neurocognitive function, especially social behavior, we have developed and characterized Gtf2i-deficient mice.

  7. Results suggest that DJ-1 (show PARK7 Proteins) together with TFII-I operate in concert to cope with various insults and to sustain pancreatic beta-cell function.

  8. behavioral characterization of heterozygous mice with a deletion of the first 140 amino-acids of TFII-I.

  9. data demonstrate that TFII-I, through a Src (show SRC Proteins)-dependent mechanism, reversibly translocates from the cytoplasm to the nucleus, leading to the transcriptional activation of growth-regulated genes

  10. acts as a transcriptional cofactor for the SUMO ubiquitin-protein isopeptide ligase family member Miz1/PIASxbeta /Siz2 (show PIAS2 Proteins)

GTF2I Protein Profile

Protein Summary

The protein encoded by this gene contains five GTF2I-like repeats and each repeat possesses a potential helix-loop-helix (HLH) motif. It may have the ability to interact with other HLH-proteins and function as a transcription factor or as a positive transcriptional regulator under the control of Retinoblastoma protein. This gene plays a role in craniofacial and cognitive development and mutations have been associated with Williams-Beuren syndrome, a multisystem developmental disorder caused by deletion of multiple genes at 7q11.23. Alternative splicing results in multiple transcript variants.

Gene names and symbols associated with GTF2I

  • general transcription factor IIi (GTF2I)
  • GTF2I repeat domain containing 1 (GTF2IRD1)
  • general transcription factor II I (Gtf2i)
  • general transcription factor IIi (gtf2i)
  • general transcription factor IIi (Gtf2i)
  • general transcription factor IIi S homeolog (gtf2i.S)
  • 6030441I21Rik protein
  • bap-135 protein
  • bap135 protein
  • BEN protein
  • btkap1 protein
  • CREAM1 protein
  • diws protein
  • gtf2i protein
  • gtf2i.L protein
  • Gtf2ird1 protein
  • GTF3 protein
  • gtfii-i protein
  • hMusTRD1alpha1 protein
  • ib291 protein
  • MUSTRD1 protein
  • RBAP2 protein
  • spin protein
  • tfii-i protein
  • wbs protein
  • wbscr6 protein
  • WBSCR11 protein
  • WBSCR12 protein

Protein level used designations for GTF2I

BTK-associated protein, 135kD , Bruton tyrosine kinase-associated protein 135 , SRF-Phox1-interacting protein , Williams-Beuren syndrome chromosome region 6 , general transcription factor II-I , USE B1-binding protein , Williams-Beuren syndrome chromosome region 11 , binding factor for early enhancer , general transcription factor 3 , general transcription factor II-I repeat domain-containing protein 1 , general transcription factor III , muscle TFII-I repeat domain-containing protein 1 alpha 1 , slow-muscle-fiber enhancer-binding protein , williams-Beuren syndrome chromosomal region 12 protein , GTFII-I , TFII-I , BTK-associated protein 135 , general transcription factor II, i , general transcription factor IIi L homeolog , general transcription factor IIi S homeolog

2969 Homo sapiens
9569 Homo sapiens
353256 Rattus norvegicus
14886 Mus musculus
534669 Bos taurus
549986 Xenopus (Silurana) tropicalis
417486 Gallus gallus
479714 Canis lupus familiaris
100724513 Cavia porcellus
443780 Xenopus laevis
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