anti-Glutamate Receptor, Metabotropic 6 (GRM6) Antibodies

has adenylate cyclase inhibiting metabotropic glutamate receptor activity\; may play a role in synaptic transmission between photoreceptor cells and ON-bipolar cells in the retina [RGD, Feb 2006].. Additionally we are shipping Metabotropic Glutamate Receptor 6 Kits (14) and Metabotropic Glutamate Receptor 6 Proteins (5) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
GRM6 24419 P35349
GRM6 2916 O15303
GRM6 108072 Q5NCH9
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Top anti-Metabotropic Glutamate Receptor 6 Antibodies at antibodies-online.com

Showing 10 out of 97 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Delivery Price Details
Human Rabbit Un-conjugated IC, IF, WB 200 μL 13 to 14 Days
$487.50
Details
Human Rabbit Un-conjugated IHC, ELISA, WB 100 μg 2 to 3 Days
$302.50
Details
Cow Rabbit Un-conjugated WB Host:  Rabbit  Target Name:  GRM6  Sample Type:  HepG2 Whole Cell lysates  Antibody Dilution:  1.0ug/ml WB Suggested Anti-GRM6 Antibody Titration:  0.2-1 ug/ml  Positive Control:  Human brain 100 μL 2 to 3 Days
$289.00
Details
Cow Rabbit Un-conjugated WB WB Suggested Anti-GRM6 Antibody Titration: 0.2-1 ug/mlELISA Titer: 1:312500Positive Control: 721_B cell lysate 100 μL 2 to 3 Days
$289.00
Details
Cow Rabbit Un-conjugated WB WB Suggested Anti-GRM6 Antibody Titration:  0.2-1 ug/ml  ELISA Titer:  1:62500  Positive Control:  Human Small Intestine 100 μL 2 to 3 Days
$289.00
Details
Bat Rabbit Un-conjugated IHC, IHC (p), WB Anti-GRM6 / MGLUR6 antibody  ABIN1048939 IHC staining of human eye, retina. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Anti-GRM6 / MGLUR6 antibody IHC of human Ovary, Carcinoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. 50 μg 11 to 14 Days
$484.00
Details
Cow Rabbit Un-conjugated WB 100 μL 11 to 14 Days
$551.83
Details
Bat Rabbit Un-conjugated IHC, IHC (p), WB Brain, cortex Anti-GRM6 / MGLUR6 antibody IHC of human brain, cortex. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml. This image was taken for the unconjugated form of this pro ... 100 μL 11 to 14 Days
$727.83
Details
Human Rabbit Un-conjugated IHC, IHC (p) Human Eye, Ganglion Cells (formalin-fixed, paraffin-embedded) stained with GRM6 antibody ABIN213492 at 5.6 ug/ml followed by biotinylated goat anti-rabbit IgG secondary antibody ABIN481713, alkaline phosphatase-streptavidin and chromogen. Anti-GRM6 / MGLUR6 antibody IHC of human Lung, Non-Small Cell Carcinoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. 50 μg 11 to 14 Days
$484.00
Details
Bat Rabbit Un-conjugated WB 100 μL 11 to 14 Days
$551.83
Details

Top referenced anti-Metabotropic Glutamate Receptor 6 Antibodies

  1. Mouse (Murine) Polyclonal Metabotropic Glutamate Receptor 6 Primary Antibody for ICC, IHC (fro) - ABIN152531 : Takada, Vijayasarathy, Zeng, Kjellstrom, Bush, Sieving: Synaptic pathology in retinoschisis knockout (Rs1-/y) mouse retina and modification by rAAV-Rs1 gene delivery. in Investigative ophthalmology & visual science 2008 (PubMed)
    Show all 3 Pubmed References

  2. Polyclonal Metabotropic Glutamate Receptor 6 Primary Antibody for IF, WB - ABIN540379 : Nakajima, Iwakabe, Akazawa, Nawa, Shigemoto, Mizuno, Nakanishi: Molecular characterization of a novel retinal metabotropic glutamate receptor mGluR6 with a high agonist selectivity for L-2-amino-4-phosphonobutyrate. in The Journal of biological chemistry 1993 (PubMed)
    Show all 2 Pubmed References

More Antibodies against Metabotropic Glutamate Receptor 6 Interaction Partners

Human Glutamate Receptor, Metabotropic 6 (GRM6) interaction partners

  1. Our data suggested that genetic variants in GRM6 are associated with high myopia. The mechanism of GRM6 in the development of high myopia need to be further investigated.

  2. Two mutations in GRM6 gene have been identified in two consanguineous Pakistani families with congenital stationary night blindness.

  3. These data suggest differences in coupling of TRPM1 function to mGluR6 signaling explain different cellular responses to glutamate in the retina and the skin.

  4. We found 5 different mutations in GRM6, in congenital stationary night blindness.

  5. The selective thinning of the inner retinal layers in patients with GRM6 mutations suggests either reduced bipolar or ganglion cell numbers or altered synaptic structure in the inner retina.

  6. The results expand the mutation spectrum of NYX, CACNA1F and GRM6. They also suggest that NYX mutations are a common cause of congenital stationary night blindness (CSNB).

  7. The phenotype associated with GRM6 mutation is variable in terms of presentation, refractive error, visual acuity and macular function. ERGs are electronegative and suggest ON-pathway dysfunction.

  8. A positive association was observed between response to methadone and two variants in the genes MYOCD and GRM6.

  9. Affected individuals in three of five families carried either compound heterozygous or homozygous mutations in GRM6.

  10. The ligand-binding and the poorly characterized cysteine-rich domains, in addition to the intracellular domains, have a pivotal role in correct trafficking of metabotropic glutamate receptors to the cell surface.

  11. A switch in G-protein coupling, in which glutamate775lysine loses G(o) subunit coupling but retains coupling to G(i), may explain the highly specialized metabotropic glutamate receptor mGlur6 phenotype.

  12. Three novel variations with potential functional consequences were identified in the GRM6 of patients with high myopia, suggesting a potential role in the development of myopia in rare cases.

Mouse (Murine) Glutamate Receptor, Metabotropic 6 (GRM6) interaction partners

  1. Laminar size and structure in missense Grm6(nob8) retina were comparable to control. The Grm6(nob8) phenotype is distinguished from other Grm6 mutants that carry a null allele by a reduced but not absent electroretinograph b-wave, decreased but present expression of mGluR6 at retinal depolarizing bipolar cells (DBCs) dendritic tips, and mislocalization of mGluR6 to DBC somas. In p.Met66Leu mutant mGluR6 is trafficked less

  2. Study suggests that the mGluR6 macromolecular complex is connected to the presynaptic rod terminal via a protein chain that includes the matrix-associated proteins. When a component of the macromolecular chain is missing, the chain may fall apart and loosen the dendritic tip adherence within the invagination.

  3. These results indicate that Grm6 nob7 is a new model of the complete form of congenital stationary night blindness.

  4. The mGluR6-KO phenotype showed negative effects on ribbon synapse formation.

  5. Diagnosis of concurrent Stargardt disease and CSNB was made on the ophthalmic history; genetic testing revealed two previously reported mutations in the ABCA4 gene and two novel deletions in the GRM6 gene.

  6. the localization and stability of Cacna1s depend on the expression of mGluR6 and its cascade components, and they suggest that Cacna1s is part of the mGluR6 complex.

  7. The results suggested that the TRPM1 channel in metabotropic glutamate receptor 6-null rod bipolar cells is inactive. Rod bipolar cells in metabotropic glutamate receptor 6-null mice were hyperpolarized.

  8. These results demonstrate that TRPM1-L is a component of the ON bipolar cell (BC) transduction channel downstream of mGluR6 in ON BCs.

  9. The mGluR6 mRNA levels are altered in the young and adult rat retina of Royal College of Surgeons rat and suggest that the genetically induced degeneration of photoreceptors affects the expression of this receptor by the INL retinal neurons.

  10. In mGluR6-null mice, long-latency ON responses are observed in the visual cortex, indicating that they can be conducted reliably to higher visual areas.

  11. mGluR6 expression was limited to the outer plexiform layer

  12. Mutation is similar to that of human patients with congenital stationary night blindness and will provide a tool for understanding retinal circuitry.

  13. Visual responses of Grm6(no b-wave3) retinal ganglion cells to light onset were abnormal.

  14. Obesity and hyperglycemia of New Zealand obese mice is to a large part caused by variant genes located in Nob3 on chromosome 1.

Metabotropic Glutamate Receptor 6 (GRM6) Antigen Profile

Protein Summary

has adenylate cyclase inhibiting metabotropic glutamate receptor activity\; may play a role in synaptic transmission between photoreceptor cells and ON-bipolar cells in the retina

Gene names and symbols associated with GRM6

  • glutamate metabotropic receptor 6 (Grm6) antibody
  • glutamate metabotropic receptor 6 (GRM6) antibody
  • glutamate receptor, metabotropic 6 (Grm6) antibody
  • glutamate receptor, metabotropic 6a (grm6a) antibody
  • glutamate receptor, metabotropic 6b (grm6b) antibody
  • BC021919 antibody
  • cb496 antibody
  • CSNB1B antibody
  • Gm3 antibody
  • Gprc1f antibody
  • GRM6 antibody
  • grma antibody
  • mGlu6 antibody
  • MGLUR6 antibody
  • nerg1 antibody
  • nob2 antibody
  • nob3 antibody
  • nob4 antibody
  • si:dkey-52h10.3 antibody
  • zgc:158329 antibody
  • zK13A21.16 antibody

Protein level used designations for GRM6

metabotropic glutamate receptor 6 , G protein-coupled receptor GRM6 , G protein-coupled receptor, family C, group 1, member F , grm6 , mglur6a , LOW QUALITY PROTEIN: metabotropic glutamate receptor 6 , glutamate receptor, metabotropic 6b , glutamate receptor, metabotropic a , metabotropic glutamate receptor 6b , mglur6b

GENE ID SPECIES
24419 Rattus norvegicus
2916 Homo sapiens
462323 Pan troglodytes
443292 Ovis aries
100009501 Oryctolagus cuniculus
108072 Mus musculus
481452 Canis lupus familiaris
568484 Danio rerio
529656 Bos taurus
100722389 Cavia porcellus
100067731 Equus caballus
102162790 Sus scrofa
565450 Danio rerio
Selected quality suppliers for anti-Metabotropic Glutamate Receptor 6 (GRM6) Antibodies
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