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Glutamate-cysteine ligase, also known as gamma-glutamylcysteine synthetase, is the first rate limiting enzyme of glutathione synthesis. Additionally we are shipping GCLM Kits (48) and GCLM Proteins (13) and many more products for this protein.
Showing 10 out of 107 products:
Human Monoclonal GCLM Primary Antibody for ELISA, WB - ABIN516058
Balamurugan, Akhov, Selvaraj, Pugazhenthi: Induction of antioxidant enzymes by curcumin and its analogues in human islets: implications in transplantation. in Pancreas 2009
Show all 4 Pubmed References
Cow (Bovine) Polyclonal GCLM Primary Antibody for IHC, WB - ABIN2785805
Jönsson, Jönsson, Axmon, Littorin, Broberg: Influence of glutathione-related genes on symptoms and immunologic markers among vulcanization workers in the southern Sweden rubber industries. in International archives of occupational and environmental health 2008
Show all 3 Pubmed References
Human Polyclonal GCLM Primary Antibody for ICC, IF - ABIN443275
Lu, Samanta, Xiang, Zhang, Hu, Chen, Bullen, Semenza: Chemotherapy triggers HIF-1-dependent glutathione synthesis and copper chelation that induces the breast cancer stem cell phenotype. in Proceedings of the National Academy of Sciences of the United States of America 2015
Glutathione biosynthesis during the lipopolysaccharide-induced inflammatory response in THP-1 (show GLI2 Antibodies) macrophages is tightly and differentially regulated via GCLC (show GCLC Antibodies) and GCLM subunits of glutamate cysteine ligase (show GCLC Antibodies).
Two promoter polymorphisms of GCLM (-588C/T) and GCLC (show GCLC Antibodies) (-128T/C) are associated with an increased risk of ischemic heart disease in Kazakhstan population.
High GCLM expression is associated with chemotherapy resistance in breast cancer.
Glutaminolysis is activated in ES2 (show DGCR14 Antibodies) and OVCAR3, though ES2 (show DGCR14 Antibodies) exclusively synthesizes amino acids and GSH. ES2 (show DGCR14 Antibodies) cells are more resistant to carboplatin than OVCAR3 and the abrogation of GSH production by BSO sensitizes ES2 (show DGCR14 Antibodies) to carboplatin. HNF1beta (show HNF1B Antibodies) regulates the expression of GCLC (show GCLC Antibodies), but not GCLM, and consequently GSH production in ES2 (show DGCR14 Antibodies)
Data suggest gene expression in vascular endothelium is altered by dietary factors; aged garlic extract induces expression of HMOX1 (heme oxygenase-1 (show HMOX1 Antibodies)) and GCLM via activation of NRF2 (show GABPA Antibodies)-ARE (nuclear factor erythroid 2-antioxidant response element) signaling.
miR-433 targets both catalytic (GCLc) and regulatory (GCLm) subunits of GCL.
Data suggest expression of hepatocyte GCLC (show GCLC Antibodies) and GCLM can be regulated by dietary component; alpha-lipoic acid, a vitamin B complex nutrient, protects against oxidative stress/cytotoxicity induced by cadmium via restoration of GCLC (show GCLC Antibodies) and GCLM expression.
miR (show MLXIP Antibodies)-320a has a role in modulating the induction of HO-1 (show HMOX1 Antibodies), GCLM and OKL38 (show OSGIN1 Antibodies) by oxidized phospholipids in endothelial cells
This study demonstrated that Tuberous sclerosis complex neuropathology requires glutamate-cysteine ligase (show GCLC Antibodies).
Knockdown of glutamate cysteine ligase catalytic subunit (show GCLC Antibodies) by siRNA causes the gold nanoparticles-induced cytotoxicity in lung cancer cells.
glutathione levels in the skin of Gclm knock-out mice are reduced by 70 %, which is sufficient for wound repair in young mice, but become rate-limiting upon aging
Gclm(-/-) mice have accelerated ovarian aging due to ovarian oxidative stress.
Upregulation of both GCLC (show GCLC Antibodies) and GLCM mRNA levels in response to cysteine deprivation was dependent on new protein synthesis.
In Gclm KO mice, early-life insults inducing oxidative stress are detrimental to immature parvalbumin (show PVALB Antibodies) interneurons and have long-term consequences.
Wild type female mice deficient in GSH due to deletion of Gclm were resistant to increase visceral adiposity and hepatic steatosis caused by exposure to the PAH BaP (show PHB2 Antibodies).
The glutathione synthesis gene Gclm modulates amphiphilic polymer-coated CdSe/ZnS quantum dot-induced lung inflammation in mice.
Anxiety and drug-stimulated locomotor control brain regions are vulnerable to gclm/glutathione deficiencies.
Clinically relevant levels of TGF-beta1 (show TGFB1 Antibodies) suppresses GCLC (show GCLC Antibodies) and GCLM expression in mouse lung.
Genetic disruption of Gclm results in reduced aortic glutathione content and impaired acetylcholine mediated aortic ring relaxation.
Data suggest that Gclm is not involved in spermatogenesis but is involved in shielding testis/epididymis from oxidative stress; Gclm knockout mice are fertile but more sensitive to transplacental testicular/epididymal toxicity of benzo[a]pyrene.
Glutamate-cysteine ligase, also known as gamma-glutamylcysteine synthetase, is the first rate limiting enzyme of glutathione synthesis. The enzyme consists of two subunits, a heavy catalytic subunit and a light regulatory subunit. Gamma glutamylcysteine synthetase deficiency has been implicated in some forms of hemolytic anemia.
glutamate-cysteine ligase regulatory subunit
, GCS light chain
, gamma-ECS regulatory subunit
, gamma-glutamylcysteine synthetase regulatory subunit
, glutamate cysteine ligase (gamma-glutamylcysteine synthetase), regulatory
, glutamate--cysteine ligase regulatory subunit
, glutamate-cysteine ligase modifier subunit
, GSC light chain
, glutamate--cysteine ligase modifier subunit
, glutamate-cysteine ligase (gamma-glutamylcysteine synthetase), regulatory (30.8kD)
, glutamate-cysteine ligase modifier subunit delta2 alternative splicing
, glutamate-cysteine ligase regulatory protein