anti-Glycine Dehydrogenase (GLDC) Antibodies

Degradation of glycine is brought about by the glycine cleavage system, which is composed of four mitochondrial protein components: P protein (a pyridoxal phosphate-dependent glycine decarboxylase), H protein (a lipoic acid-containing protein), T protein (a tetrahydrofolate-requiring enzyme), and L protein (a lipoamide dehydrogenase). Additionally we are shipping Glycine Dehydrogenase Kits (22) and Glycine Dehydrogenase Proteins (9) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
GLDC 104174 Q91W43
GLDC 2731 P23378
GLDC 309312  
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Top anti-Glycine Dehydrogenase Antibodies at antibodies-online.com

Showing 10 out of 67 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Delivery Price Details
Human Rabbit Un-conjugated ICC, IHC, WB Western Blot; Sample: Mouse Liver lysate; Primary Ab: 2µg/ml Rabbit Anti-Human GLDC Antibody Second Ab: 0.2µg/mL HRP-Linked Caprine Anti-Rabbit IgG Polyclonal Antibody (Catalog: SAA544Rb19) 100 μg 15 to 18 Days
$350.00
Details
Human Rabbit Un-conjugated ICC, IF, IP, IHC (p) IP Image Immunoprecipitation of Glycine dehydrogenase protein from HepG2 whole cell extracts using 5 μg of Glycine dehydrogenase antibody [N3C2-2], Internal, Western blot analysis was performed using Glycine dehydrogenase antibody [N3C2-2], Internal, EasyBlot anti-Rabbit IgG  was used as a secondary reagent. ICC/IF Image Glycine dehydrogenase antibody [N3C2-2], Internal detects Glycine dehydrogenase protein at mitochondria by immunofluorescent analysis. Sample: HepG2 cells were fixed in ice-cold MeOH for 5 min. Green: Glycine dehydrogenase protein stained by Glycine dehydrogenase antibody [N3C2-2], Internal , diluted at 1:500. Blue: Hoechst 33342 staining. 100 μL 3 to 4 Days
$466.18
Details
Human Rabbit Un-conjugated EIA, WB Western blot analysis of GLDC Antibody (N-term) in mouse liver tissue lysates (35ug/lane). GLDC (arrow) was detected using the purified Pab. 0.4 mL 6 to 8 Days
$484.00
Details
Human Rabbit Un-conjugated ICC, IHC, WB Figure.DAB staining on IHC-P. Samples: Human Tissue 100 μg 13 to 16 Days
$350.00
Details
Mouse Rabbit Un-conjugated ICC, IHC, WB Used in DAB staining on fromalin fixed paraffin-embedded liver tissue 100 μg 13 to 16 Days
$360.00
Details
Human Rabbit Un-conjugated WB Western Blot at 1:1000 dilution + HepG2 whole cell lysate Lysates/proteins at 20 ug per lane. Western blot analysis of GLDC Antibody in mouse liver tissue lysates (35ug/lane) 400 μL 2 to 3 Days
$515.63
Details
Human Rabbit Un-conjugated WB Western blot analysis of extracts of various cells, using GLDC antibody. 100 μL 11 to 13 Days
$366.77
Details
Cow Rabbit Un-conjugated WB   100 μL 2 to 3 Days
$289.00
Details
Human Rabbit Un-conjugated IF/ICC, IHC, IP, WB Western blot analysis of Mouse Liver lysate, using Human GLDC Antibody (2 µg/ml) and HRP-conjugated Goat Anti-Rabbit antibody ( Western blot analysis of the recombinant protein. 100 μg 11 to 18 Days
$440.62
Details
Human Rabbit Un-conjugated WB Western blot analysis of extracts of various cell lines, using GLDC antibody. 200 μL 12 to 14 Days
$438.90
Details

Top referenced anti-Glycine Dehydrogenase Antibodies

  1. Human Polyclonal GLDC Primary Antibody for IHC, IHC (p) - ABIN4314242 : Kim, Fiske, Birsoy, Freinkman, Kami, Possemato, Chudnovsky, Pacold, Chen, Cantor, Shelton, Gui, Kwon, Ramkissoon, Ligon, Kang, Snuderl, Vander Heiden, Sabatini: SHMT2 drives glioma cell survival in ischaemia but imposes a dependence on glycine clearance. in Nature 2015 (PubMed)

More Antibodies against Glycine Dehydrogenase Interaction Partners

Mouse (Murine) Glycine Dehydrogenase (GLDC) interaction partners

  1. Exencephaly and ventriculomegaly were detectable by High-frequency ultrasound in homozygous Gldc-deficient mouse embryos indicating this to be an effective tool to study CNS development.

  2. These studies support a direct relationship between p53 mutations and GLDC expression in B cell lymphoma.

  3. Glycine decarboxylase deficiency causes neural tube defects and features of non-ketotic hyperglycinemia in mice through limiting supply of one-carbon units from mitochondrial folate metabolism.

  4. Results suggest that there is a direct correlation between ischemic injury and extracellular glycine concentration maintained by glycine decarboxylase and the glycine cleavage multienzyme system.

Human Glycine Dehydrogenase (GLDC) interaction partners

  1. Collectively, GLDC regulates cellular antiviral response and orchestrates viral growth. GLDC is a functional susceptibility gene to severe influenza in humans.

  2. these findings suggest that GLDC-mediated regulation of glycolysis and controlling AGE accumulation is related to maintenance and induction of pluripotency.

  3. Our data indicate that GLDC downregulation decreases reactive oxygen species mediated ubiquitination of cofilin to enhance hepatocellular carcinoma progression and intrahepatic metastasis

  4. A novel compound heterozygous variant was identified in the GLDC gene in a Chinese family with non-ketotic hyperglycinemia

  5. it was concluded that elevated serum GLDC may increase lung cancer risk, and that smoking, GLDC, the miR29 family and DNMT signaling pathways may serve an important role in early malignant transformation during the development of lung cancer.

  6. a comprehensive functional and structural analysis of 19 GLDC missense variants identified in a cohort of 26 nonketotic hyperglycinemia patients was performed

  7. The position and frequency of the breakpoint for CNVs correlated with intron size and presence of Alu elements. Missense mutations, most often recurring, were the most common type of disease-causing mutation in AMT

  8. We show that the combination of GLDC and HIF-1alpha expression is an independent prognostic factor in early-stage lung non-small cell cancer

  9. Data indicate no mutation was found in glycine cleavage system protein-H (GCSH) and suggest that mutations in both glycine decarboxylase (GLDC) and aminomethyltransferase (AMT) are the main cause of glycine encephalopathy in Malaysian population.

  10. study reports a novel mutation, c.2296G>T (p.Gly766Cys), in exon 19 of the glycine decarboxylase (GLDC) gene in a consanguineous Indian couple with a history of 4 neonatal deaths

  11. Identification of a splice acceptor site mutation and five different non-synonymous variants in GLDC were found in patients with neural tube defects.

  12. Study shows that glycine metabolism and the metabolic enzyme glycine decarboxylase (GLDC) drive tumor-initiating cells and tumorigenesis in non-small cell lung cancer.

  13. Heterozygous GLDC gene mutation in transient neonatal hyperglycinemia.

  14. Missense and nonsense mutations found in glycine encephalopathy

  15. Three adults with mild hyperglycinemia, infantile hypotonia, mental retardation, behavioral hyperirritability, and aggressive outbursts were screened for glycine decarboxylase mutations; two novel missense mutations were found.

  16. The mutation in this nonketotic hyperglycinemia kindred led to missplicing and reduced GLDC (glycine decarboxylase) expression.

  17. Single nucleotide substitution that abolishes the initiator methionine codon of the GLDC gene is associated with glycine encephalopathy

  18. the nonketotic hyperglycinemia is due to a novel GLDC mutation.

  19. forty different gene alterations in the GLDC gene were identified in patients with glycine encephalopathy

  20. A screening system for GLDC deletions by multiplex ligation-dependent probe amplification identified 14 deletions of different length & Alu-mediated recombination in non-ketotic hyperglycinaemia patients.

Glycine Dehydrogenase (GLDC) Antigen Profile

Protein Summary

Degradation of glycine is brought about by the glycine cleavage system, which is composed of four mitochondrial protein components: P protein (a pyridoxal phosphate-dependent glycine decarboxylase), H protein (a lipoic acid-containing protein), T protein (a tetrahydrofolate-requiring enzyme), and L protein (a lipoamide dehydrogenase). The protein encoded by this gene is the P protein, which binds to glycine and enables the methylamine group from glycine to be transferred to the T protein. Defects in this gene are a cause of nonketotic hyperglycinemia (NKH).

Gene names and symbols associated with GLDC

  • glycine dehydrogenase (decarboxylating) GcvP (gcvP) antibody
  • glycine dehydrogenase (gcvP) antibody
  • glycine dehydrogenase (Tb927.7.1910) antibody
  • glycine cleavage system P-protein (gcvP) antibody
  • glycine decarboxylase (Gldc) antibody
  • glycine decarboxylase (GLDC) antibody
  • glycine dehydrogenase (decarboxylating) (gldc) antibody
  • glycine decarboxylase S homeolog (gldc.S) antibody
  • D030049L12Rik antibody
  • D19Wsu57e antibody
  • DDBDRAFT_0219205 antibody
  • DDBDRAFT_0231130 antibody
  • DDB_0219205 antibody
  • DDB_0231130 antibody
  • fb23b05 antibody
  • GCE antibody
  • GCSP antibody
  • gldc antibody
  • HYGN1 antibody
  • PSPTO1276 antibody
  • Tb07.43M14.350 antibody
  • wu:fb23b05 antibody
  • zgc:66198 antibody

Protein level used designations for GLDC

glycine dehydrogenase , glycine cleavage system P protein , glycine dehydrogenase [decarboxylating], mitochondrial , glycine cleavage system protein P , glycine decarboxylase P-protein , glycine cleavage system protein P) , glycine decarboxylase , glycine dehydrogenase (decarboxylating; glycine decarboxylase, glycine cleavage system protein P) , glycine decarboxylase, glycine cleavage system protein P) , glycine dehydrogenase (decarboxylating), mitochondrial , glycine decarboxylase S homeolog , glycine dehydrogenase (decarboxylating) S homeolog

GENE ID SPECIES
1168636 Shewanella oneidensis MR-1
1182912 Pseudomonas syringae pv. tomato str. DC3000
3196586 Ruegeria pomeroyi DSS-3
3658401 Trypanosoma brucei brucei strain 927/4 GUTat10.1
8626028 Dictyostelium discoideum AX4
104174 Mus musculus
2731 Homo sapiens
374222 Gallus gallus
309312 Rattus norvegicus
481534 Canis lupus familiaris
321621 Danio rerio
379833 Xenopus laevis
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