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GLDC antibody (AA 51-150)

GLDC Reactivity: Human WB, ELISA, ICC, IF (cc), IF (p), IHC (p), IHC (fro) Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN1714460
  • Target See all GLDC Antibodies
    GLDC (Glycine Dehydrogenase (GLDC))
    Binding Specificity
    • 14
    • 8
    • 8
    • 7
    • 4
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 51-150
    Reactivity
    • 46
    • 13
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Human
    Host
    • 47
    Rabbit
    Clonality
    • 47
    Polyclonal
    Conjugate
    • 17
    • 6
    • 5
    • 4
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This GLDC antibody is un-conjugated
    Application
    • 43
    • 18
    • 12
    • 12
    • 8
    • 5
    • 4
    • 4
    • 3
    • 2
    • 2
    • 1
    • 1
    Western Blotting (WB), ELISA, Immunocytochemistry (ICC), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))
    Predicted Reactivity
    Human,Mouse,Rat,Dog,Horse,Rabbit
    Purification
    Purified by Protein A.
    Immunogen
    KLH conjugated synthetic peptide derived from human GLDC
    Isotype
    IgG
    Top Product
    Discover our top product GLDC Primary Antibody
  • Application Notes
    WB 1:300-5000
    ELISA 1:500-1000
    IHC-P 1:200-400
    IHC-F 1:100-500
    IF(IHC-P) 1:50-200
    IF(IHC-F) 1:50-200
    IF(ICC) 1:50-200
    ICC 1:100-500
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 μg/μL
    Buffer
    0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.
    Preservative
    ProClin
    Precaution of Use
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
    Storage
    4 °C,-20 °C
    Storage Comment
    Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.
    Expiry Date
    12 months
  • Target
    GLDC (Glycine Dehydrogenase (GLDC))
    Alternative Name
    GLDC (GLDC Products)
    Synonyms
    PSPTO1276 antibody, Tb07.43M14.350 antibody, DDBDRAFT_0219205 antibody, DDBDRAFT_0231130 antibody, DDB_0219205 antibody, DDB_0231130 antibody, D030049L12Rik antibody, D19Wsu57e antibody, GCE antibody, GCSP antibody, HYGN1 antibody, fb23b05 antibody, wu:fb23b05 antibody, zgc:66198 antibody, gldc antibody, glycine dehydrogenase (decarboxylating) GcvP antibody, glycine dehydrogenase antibody, glycine cleavage system P-protein antibody, glycine decarboxylase antibody, glycine dehydrogenase (decarboxylating) antibody, glycine decarboxylase S homeolog antibody, gcvP antibody, Tb927.7.1910 antibody, Gldc antibody, GLDC antibody, gldc antibody, gldc.S antibody
    Background

    Synonyms: GCE, GCSP, GCSP_HUMAN, GLDC, Glycine cleavage system P protein, glycine cleavage system protein P, Glycine decarboxylase, glycine decarboxylase P protein, Glycine dehydrogenase decarboxylating mitochondrial, Glycine dehydrogenase [decarboxylating], mitochondrial, Gycine dehydrogenase decarboxylating, HYGN1, MGC138198, MGC138200, NKH.

    Background: The glycine cleavage system is comprised of AMT (known as Protein T), GCSH (known as Protein H), DLD (known as Protein L) and GLDC (known as Protein P), all of which work together to catalyze the cleavage and degradation of glycine. GLDC (glycine dehydrogenase ), also known as GCE, GCSP (glycine cleavage system P protein) or HYGN1, is a 1,020 amino acid protein that localizes to the mitochondria and belongs to the gcvP family. GLDC binds to glycine and enables the methylamine group from glycine to be transferred to the Protein T. GLDC exists as a homodimer and utilizes pyridoxal phosphate as a cofactor. Mutations in the gene encoding GLDC leads to nonketotic hyperglycinemia (NKH), also known as glycine encephalopathy (GCE), an autosomal recessive disease characterized by accumulation of a large amount of glycine in body fluid and by severe neurological symptoms.

    Gene ID
    2731
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