anti-Glycoprotein Ib (Platelet), alpha Polypeptide (GP1BA) Antibodies

Glycoprotein Ib (GP Ib) is a platelet surface membrane glycoprotein composed of a heterodimer, an alpha chain and a beta chain, that is linked by disulfide bonds. Additionally we are shipping Glycoprotein Ib (Platelet), alpha Polypeptide Kits (15) and Glycoprotein Ib (Platelet), alpha Polypeptide Proteins (15) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
GP1BA 691992  
GP1BA 14723 O35930
GP1BA 2811  
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Top anti-Glycoprotein Ib (Platelet), alpha Polypeptide Antibodies at antibodies-online.com

Showing 10 out of 207 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Dog Rabbit Un-conjugated WB <b>WB Suggested Anti-GP1BA Antibody Titration: </b>0.2-1 ug/ml<br><b>Positive Control: </b>Jurkat cell lysate 100 μL Log in to see 2 to 3 Days
$289.00
Details
Guinea Pig Rabbit Un-conjugated WB Host: Rabbit Target Name: GP1BA Sample Type: Jurkat Whole Cell lysates Antibody Dilution: 1.0ug/ml 100 μL Log in to see 2 to 3 Days
$289.00
Details
Human Rabbit Un-conjugated WB Western blot analysis of CD42b expression in Hela (A), NIH3T3 (B), H9C2 (C) whole cell lysates. 200 μL Log in to see 13 to 14 Days
$487.50
Details
Human Sheep Un-conjugated CyTOF, FACS, WB Detection of Human CD42b/GPIb alpha in Human Whole Blood CD41+ Platelets by Flow Cytometry. Detection of Human CD42b/GPIb alpha by Western Blot. Western blot shows lysates of human platelets. PVDF membrane was probed with 1 ug/mL of Sheep Anti-Human CD42b/GPIb alpha Antigen Affinity-purified Polyclonal Antibody. This experiment was conducted under reducing conditions. 100 μg Log in to see 8 to 9 Days
$416.30
Details
Human Mouse Un-conjugated FACS, IP, ELISA Staining of human peripheral blood platelets with MOUSE ANTI HUMAN CD42b:FITC Flow Cytometry: CD42b/GPIb alpha Antibody (AK2) [ABIN2548960] - Analysis using the FITC conjugate of ABIN2548960. Staining of human peripheral blood platelets with MOUSE ANTI HUMAN CD42b:FITC. 0.1 mg Log in to see 7 to 9 Days
$444.19
Details
Human Rabbit Un-conjugated ICC, IHC, WB Figure. Western Blot; Sample: Human Lymphocytes Cells. 100 μg Log in to see 13 to 16 Days
$332.00
Details
Human Mouse Un-conjugated FACS, IHC 500 μg Log in to see 10 to 12 Days
$345.28
Details
Human Mouse APC FACS, Func, IHC (f) Surface staining of human platelets with anti-CD42b(HIP1) PE. 100 Tests Log in to see 5 to 7 Days
$366.85
Details
Human Mouse FITC FACS Staining of human peripheral blood platelets with MOUSE ANTI HUMAN CD42b:FITC 0.1 mg Log in to see 7 to 9 Days
$547.69
Details
Human Mouse Biotin FACS Staining of human peripheral blood platelets with MOUSE ANTI HUMAN CD42b:BIOTIN 0.1 mg Log in to see 7 to 9 Days
$547.69
Details

GP1BA Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality Conjugate
Rat (Rattus) ,


Mouse (Murine) ,


Human , , , ,
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Top referenced anti-Glycoprotein Ib (Platelet), alpha Polypeptide Antibodies

  1. Human Monoclonal GP1BA Primary Antibody for ICC, FACS - ABIN2749168 : Welsh, Colace, Muthard, Stalker, Brass, Diamond: Platelet-targeting sensor reveals thrombin gradients within blood clots forming in microfluidic assays and in mouse. in Journal of thrombosis and haemostasis : JTH 2014 (PubMed)
    Show all 2 Pubmed References

  2. Human Monoclonal GP1BA Primary Antibody for ICC, FACS - ABIN2749169 : Vettore, Scandellari, Moro, Lombardi, Scapin, Randi, Fabris et al.: Novel point mutation in a leucine-rich repeat of the GPIbalpha chain of the platelet von Willebrand factor receptor, GPIb/IX/V, resulting in an inherited dominant form of Bernard-Soulier syndrome ... in Haematologica 2008 (PubMed)
    Show all 2 Pubmed References

  3. Human Monoclonal GP1BA Primary Antibody for FACS, IF - ABIN1112144 : Williams, Jackson: Analysis of populations of macrophage-granulocyte progenitor cells stimulated by activities in mouse lung-conditioned medium. in Experimental hematology 1978 (PubMed)

  4. Human Monoclonal GP1BA Primary Antibody for FACS - ABIN2480377 : Sell, Purut, Silva, Jones: Recovery of myocardial function during coronary artery bypass grafting. Intraoperative assessment by pressure-volume loops. in The Journal of thoracic and cardiovascular surgery 1991 (PubMed)
    Show all 3 Pubmed References

  5. Human Monoclonal GP1BA Primary Antibody for FACS - ABIN2480381 : Burgess, Lopez, Berndt, Dawes, Chesterman, Chong: Quinine-dependent antibodies bind a restricted set of epitopes on the glycoprotein Ib-IX complex: characterization of the epitopes. in Blood 1998 (PubMed)
    Show all 3 Pubmed References

  6. Human Monoclonal GP1BA Primary Antibody for FACS, IP - ABIN2480375 : Burgess, Lopez, Gaudry, Chong: Rifampicin-dependent antibodies bind a similar or identical epitope to glycoprotein IX-specific quinine-dependent antibodies. in Blood 2000 (PubMed)
    Show all 3 Pubmed References

More Antibodies against Glycoprotein Ib (Platelet), alpha Polypeptide Interaction Partners

Cow (Bovine) Glycoprotein Ib (Platelet), alpha Polypeptide (GP1BA) interaction partners

  1. both the gpIb-VWF (show VWF Antibodies) interaction and the integrin alpha(2 (show ITGA2 Antibodies))beta(1)-collagen interaction contribute to platelet adhesion under high shear stress; integrin alpha(II (show GSTA3 Antibodies))beta(1) makes a greater contribution to adhesion to type I collagen because less VWF (show VWF Antibodies) is bound

Mouse (Murine) Glycoprotein Ib (Platelet), alpha Polypeptide (GP1BA) interaction partners

  1. this study shows that atheroma formation is inhibited in GPIba-deficient mice on atherosclerosis-prone background

  2. allosteric inhibitor SbO4L targets the glycoprotein Ibalpha-binding and heparin-binding site of thrombin (show F2 Antibodies)

  3. Thrombin (show F2 Antibodies) cleavage of platelet PAR4 (show F2RL3 Antibodies) promotes leukocyte recruitment to sites of vascular injury. This process is negatively regulated by GPIbalpha.

  4. GPIbalpha-mediated interactions between platelets and endothelial cells, as well as leukocytes, support innate immune cell recruitment and promote arteriogenesis-establishing platelets as critical players in this process.

  5. Atherosclerosis reduction in mice lacking GPIbalpha may not result from the defective GPIbalpha-ligand binding, but more likely is a consequence of functional defects of GPIbalpha-/- platelets and reduced blood platelet counts.

  6. Data suggest that targeting platelet receptor glycoprotein Ibalpha (GPIbalpha)-von Willebrand factor VWF (show VWF Antibodies)-A1 binding interface may offer a therapeutic approach to reducing platelet-driven thrombosis.

  7. Following endothelial damage, platelet cross-linking during closure of the vessel lumen is mediated by GPIbalpha-VWF (show VWF Antibodies) interactions.

  8. Platelet IKKbeta (show IKBKB Antibodies) deficiency increases the formation of injury-induced arterial neointimal tissue via delayed glycoprotein Ibalpha shedding.

  9. these data demonstrate that coordinated expression of GPIbalpha and filamin (show FLNA Antibodies) is required for efficient trafficking of either protein to the cell surface, and for production of normal-sized platelets.

  10. Desialylation of platelet VWFR therefore triggers platelet clearance and primes GPIbalpha and GPV (show GP5 Antibodies) for MP-dependent cleavage.

Human Glycoprotein Ib (Platelet), alpha Polypeptide (GP1BA) interaction partners

  1. ERK5 (show MAPK7 Antibodies) associates with CKII (show CSNK2A1 Antibodies) to play essential roles in GPIb-IX-mediated platelet activation via the PTEN/PI3K (show PIK3CA Antibodies)/Akt (show AKT1 Antibodies) pathway.

  2. There was no evidence to suggest that polymorphisms of GP VI T13254C and GP Ibalpha VNTR were associated with CAD (show CAD Antibodies).

  3. analysis of an artificial botrocetin that can inhibit the VWF (show VWF Antibodies)-GPIb interaction

  4. Loss of the platelet surface receptors GPIbalpha and GPVI (show GP6 Antibodies) in heart failure, CF-VAD (show KCTD1 Antibodies) and ECMO patients may contribute to ablated platelet adhesion/activation, and limit thrombus formation under high/pathologic shear conditions

  5. Very low birth weight preterm neonates have increased numbers of platelets interacting with von Willebrand Factor (show VWF Antibodies), and increased GPIbalpha expression on the platelet surface

  6. Data suggest that an aspartate at position 1261 is the most critical residue of VWF (show VWF Antibodies) N-terminal linker for inhibiting binding of VWF (show VWF Antibodies) A1 domain to GP1BA on platelets in a model simulating blood flow velocity; network of salt bridges between Asp1261 and rest of VWF (show VWF Antibodies) A1 domain lock N-terminal linker in place such that binding to GP1BA is reduced.

  7. Data show that von Willebrand factor (VWF (show VWF Antibodies)) is first converted from a compact to linear form by flow, and is subsequently activated to bind platelet glycoprotein Ib alpha polypeptide (show ITGAE Antibodies) (GPIbalpha) in a tension-dependent manner.

  8. The >30 nm macroglycopeptide separating the two domains of GPIbalpha transmits force on the VWF (show VWF Antibodies)-GPIbalpha bond (whose lifetime is prolonged by leucine-rich repeat domain unfolding) to the juxtamembrane mechanosensitive domain to enhance its unfolding, resulting in unfolding cooperativity at an optimal force.

  9. Meta-analysis found that glycoprotein Ia (show MMRN1 Antibodies) C807T T allele or the TT genotype, the Ser (show SIGLEC1 Antibodies)-allele of HPA-3 and B allele of glycoprotein Ibalpha variable number tandem repeat polymorphisms were associated with increased risk for ischemic stroke.

  10. Our results suggest that the -5CC genotype in Kozak sequence of GPIb-alpha may be associated with a higher risk of developing arterial ischemia of lower limbs in type 2 diabetes mellitus patients.

Glycoprotein Ib (Platelet), alpha Polypeptide (GP1BA) Antigen Profile

Protein Summary

Glycoprotein Ib (GP Ib) is a platelet surface membrane glycoprotein composed of a heterodimer, an alpha chain and a beta chain, that is linked by disulfide bonds. The Gp Ib functions as a receptor for von Willebrand factor (VWF). The complete receptor complex includes noncovalent association of the alpha and beta subunits with platelet glycoprotein IX and platelet glycoprotein V. The binding of the GP Ib-IX-V complex to VWF facilitates initial platelet adhesion to vascular subendothelium after vascular injury, and also initiates signaling events within the platelet that lead to enhanced platelet activation, thrombosis, and hemostasis. This gene encodes the alpha subunit. Several polymorphisms and mutations have been described in this gene, some of which are the cause of Bernard-Soulier syndromes and platelet-type von Willebrand disease.

Gene names and symbols associated with GP1BA

  • glycoprotein Ib platelet alpha subunit (Gp1ba) antibody
  • glycoprotein Ib (platelet), alpha polypeptide (GP1BA) antibody
  • glycoprotein Ib platelet alpha subunit (GP1BA) antibody
  • glycoprotein 1b, alpha polypeptide (Gp1ba) antibody
  • BDPLT1 antibody
  • BDPLT3 antibody
  • BSS antibody
  • CD42B antibody
  • CD42b-alpha antibody
  • DBPLT3 antibody
  • GP1B antibody
  • GP1BA antibody
  • GPIbA antibody
  • GPIbalpha antibody
  • VWDP antibody

Protein level used designations for GP1BA

glycoprotein 1b, alpha polypeptide , platelet glycoprotein Ib alpha chain , glycoprotein Ib (platelet), alpha polypeptide , platelet glycoprotein Ib alpha polypeptide , GP-Ib alpha , glycoprotein Ibalpha , antigen CD42b-alpha , platelet membrane glycoprotein 1b-alpha subunit , GPIb-alpha , GPIbA

GENE ID SPECIES
691992 Rattus norvegicus
420059 Gallus gallus
468166 Pan troglodytes
504977 Bos taurus
14723 Mus musculus
2811 Homo sapiens
403638 Canis lupus familiaris
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