Glycoprotein Ib (Platelet), alpha Polypeptide (GP1BA) antibody

Details for Product No. ABIN94113
Antigen
Reactivity
Human, Non-Human Primate
186
21
12
10
5
1
1
1
1
Host
Mouse
135
52
2
Clonality (Clone)
Monoclonal ()
Conjugate
Un-conjugated
24
20
15
9
3
2
2
2
2
2
2
2
1
1
1
Application
Flow Cytometry (FACS), Functional Studies (Func), Immunohistochemistry (Formalin-fixed Sections) (IHC (f))
126
74
48
39
21
16
16
12
11
11
4
2
1
1
1
1
Options
Immunogen Peripheral blood mononuclear cells of a patient suffering with CLL.
Clone HIP1
Isotype IgG1
Specificity The antibody HIP1 reacts with CD42b (GPIb alpha), a 135-145 kDa membrane glycoprotein expressed on platelets and megakaryocytes. CD42b and CD42c (GPIb beta) are composed in a disulfide linked heterodimer (CD42b/c, 160 kDa), CD42b/c forms a noncovalent complex with CD42a and CD42d.
HLDA IV, WS Code P 40
Cross-Reactivity (Details) Human, Non-Human Primates
Purification Purified by protein-A affinity chromatography
Purity > 95 % (by SDS-PAGE)
Antigen
Alternative Name CD42b (GP1BA Antibody Abstract)
Background CD42b (GPIb alpha) composes together with GPIb beta, GPIX and GPV the GPIb-IX-V receptor complex critical in the process of platelet-rich thrombus formation by tethering the platelet to a thrombogenic surface. CD42b binds to von Willebrand factor (VWF) exposed at a site of vascular injury, as well as to thrombin, coagulation factors XI and XII, high molecular wight kininogen, TSP-1, integrin Mac-1 and P-selectin. The extracellular domain of CD42b by its interactions also contributes to metastasis.
Application Notes Optimal working dilution should be determined by the investigator.
Restrictions For Research Use only
Concentration 1 mg/mL
Buffer Phosphate buffered saline (PBS) with 15 mM sodium azide, approx. pH 7.4
Preservative Sodium azide
Precaution of Use This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Do not freeze.
Storage 4 °C
Storage Comment Store at 2-8°C. Do not freeze. Do not use after expiration date stamped on vial label.
Supplier Images
Image no. 1 for anti-Glycoprotein Ib (Platelet), alpha Polypeptide (GP1BA) antibody (ABIN94113) Surface staining of human platelets with anti-CD42b(HIP1) PE.