anti-Glycoprotein Ib (Platelet), beta Polypeptide (GP1BB) Antibodies

Platelet glycoprotein Ib (GPIb) is a heterodimeric transmembrane protein consisting of a disulfide-linked 140 kD alpha chain and 22 kD beta chain. Additionally we are shipping GP1BB Proteins (10) and GP1BB Kits (8) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
GP1BB 2812 P13224
GP1BB 116727 Q9JJM7
GP1BB 14724 P56400
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Top anti-GP1BB Antibodies at

Showing 10 out of 42 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Delivery Price Details
Human Rabbit Un-conjugated WB Western blot analysis of CD42c expression in Raji (A), HL60 (B), SP2/0 (C), rat heart (D) whole cell lysates. 200 μL 13 to 14 Days
Human Rabbit Un-conjugated ELISA, IHC, WB Western blot analysis GP1BB using HeLa whole cell lysates ABIN6279671 at 1/100 staining Human brain cancer tissue by IHC-P. The sample was formaldehyde fixed and a heat mediated antigen retrieval step in citrate buffer was performed. The sample was then blocked and incubated with the antibody for 1.5 hours at 22¡ãC. An HRP conjugated goat anti-rabbit antibody was used as the secondary 100 μL 11 to 12 Days
Human Rabbit Un-conjugated IHC, IHC (p), WB Human Heart: Formalin-Fixed, Paraffin-Embedded (FFPE) Human Colon: Formalin-Fixed, Paraffin-Embedded (FFPE) 50 μL 11 to 14 Days
Human Mouse Un-conjugated IHC, IHC (p), IP, WB Human Spleen (formalin-fixed, paraffin-embedded) stained with GP1BB antibody ABIN396968 at 1:50 followed by biotinylated anti-mouse IgG secondary antibody ABIN481714, alkaline phosphatase-streptavidin and chromogen. Anti-GP1BB / CD42c antibody IHC of human spleen. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 1:50. 50 μg 11 to 14 Days
Human Rabbit Un-conjugated ELISA, WB   100 μL Available
Rat Rabbit Un-conjugated ICC, IHC, WB Figure.DAB staining on IHC-P. Samples: Rat Tissue 100 μg 13 to 16 Days
Mouse Rabbit Un-conjugated ICC, IHC, WB Used in DAB staining on fromalin fixed paraffin-embedded Liver tissue 100 μg 13 to 16 Days
Human Rabbit Un-conjugated WB Western blot analysis of extracts of various cells, using GP1BB antibody. Western blot analysis of extracts of various cell lines, using GP1BB antibody (ABIN4903804) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 90s. 100 μL 11 to 13 Days
Human Rabbit Un-conjugated IHC (p), WB Human Colon: Formalin-Fixed, Paraffin-Embedded (FFPE) Human Heart: Formalin-Fixed, Paraffin-Embedded (FFPE) 50 μL 6 to 8 Days
Human Rabbit Un-conjugated WB WB Image Sample (30 ug of whole cell lysate) A: Raji 12% SDS PAGE antibody diluted at 1:1000 100 μL 3 to 4 Days

More Antibodies against GP1BB Interaction Partners

Human Glycoprotein Ib (Platelet), beta Polypeptide (GP1BB) interaction partners

  1. loss of CD34 and expression of CD42b define cells capable of factor V endocytosis and trafficking to proplatelet extensions during differentiation of megakaryocytes ex vivo from progenitor cells isolated from umbilical cord blood

  2. Rare variants in GP1BB are responsible for autosomal dominant macrothrombocytopenia.

  3. miR-10a and miR10b regulate the expression of human platelet GP1BA and GP1bb for normal megakaryopoiesis.

  4. Data show that localization of the GP Ib-IX complex to the lipid domain is mediated by GP Ibbeta and GP IX transmembrane domains.

  5. Low levels of CD9 coincidental with a novel nonsense mutation in glycoprotein Ibbeta in a patient with Bernard-Soulier syndrome.

  6. genetic association study in population in western India: Data suggest novel mutations in platelet glycoprotein Ib (GP1BA, GP1BB) and GP9 are associated with Bernard-Soulier syndrome in subjects studies; of 12 mutations identified, ten were novel.

  7. a suspicion of 22q11.2 deletion is warranted in pediatric BSS patients with a mutation in the GPIbbeta gene, even without remarkable symptoms.

  8. Studies indicate that platelets from Bernard-Soulier syndrome (BSS) are defective in glycoprotein (GP)Ib-IX-V, a platelet-specific adhesion-signaling complex, composed of GPIbalpha disulfide linked to GPIbbeta, and noncovalently associated with GPIX and GPV.

  9. GPIbbeta missense mutations from Bernard-Soulier syndrome were examined for changes to GPIb-IX complex surface expression. Mutations A108P and P74R were found to maintain normal secretion/folding of GPIbbeta(E) but were unable to support GPIX surface expression

  10. A novel variant of Bernard Soulier syndrome is described in which Ser23 of GPIbbeta is substituted by a Stop codon causing a premature termination of translation.

  11. A 14-month-old boy with Bernard-Soulier syndrome was found to be homozygous for a nonsense mutation (c.423C > A) in the glycoprotein Ib-beta.

  12. Report glycoprotein Ib/IX complex mutations found in Bernard-Soulier syndrome in Indian patients.

  13. GPIIb/IIIa is the primary receptor set involved in platelet adhesion to adsorbed fibrinogen and serum albumin irrespective of their degree of adsorption-induced unfolding, while the GPIb-IX-V receptor complex plays an insignificant role.

  14. GP Ibbeta/GP IX mediates the disulfide-linked GP Ibalpha localization to the GEMs, which is critical for vWf interaction at high shear

  15. Identify TRAF4 as a novel binding partner for GPIb-IX-V and GPVI in human platelets.

  16. -induced activation of GpIb-V-IX triggers platelet procoagulant activity and anchorage of a star-like fibrin network.

  17. putative convex surface of the LRR domain in GPIX is sufficient, in the context of full-length subunit, to mediate its association with GPIbbeta

  18. Lateral clustering of platelet GP Ib-IX complexes leads to up-regulation of the adhesive function of integrin alpha IIbbeta 3

  19. Role of GPIbbeta in modulating vWF mediated platelet adhesion.

  20. A GP1BB missense mutation suppresses GPIb/IX complex expression and is found to cause Bernard-Soulier Syndrome in the homozygous form and giant platelets in the heterozygous form.

Mouse (Murine) Glycoprotein Ib (Platelet), beta Polypeptide (GP1BB) interaction partners

  1. These results indicate that Reelin is an important regulator of GPIb-mediated platelet activation and may represent a new therapeutic target for the prevention and treatment of cardio- and cerebrovascular diseases

  2. GPIbbeta has a repressor function in thrombus formation

  3. These data indicate an important role for the platelet adhesion receptor GPIb-IX in endotoxin-induced thrombosis and thrombocytopenia.

  4. Data show that the surface-bound VWF appears as a large, linear structure on the surface of 50% of the PT-VWD platelets.

  5. Role of GPIbbeta in modulating vWF mediated platelet adhesion.

GP1BB Antigen Profile

Protein Summary

Platelet glycoprotein Ib (GPIb) is a heterodimeric transmembrane protein consisting of a disulfide-linked 140 kD alpha chain and 22 kD beta chain. It is part of the GPIb-V-IX system that constitutes the receptor for von Willebrand factor (VWF), and mediates platelet adhesion in the arterial circulation. GPIb alpha chain provides the VWF binding site, and GPIb beta contributes to surface expression of the receptor and participates in transmembrane signaling through phosphorylation of its intracellular domain. Mutations in the GPIb beta subunit have been associated with Bernard-Soulier syndrome, velocardiofacial syndrome and giant platelet disorder. The 206 amino acid precursor of GPIb beta is synthesized from a 1.0 kb mRNA expressed in plateletes and megakaryocytes. A 411 amino acid protein arising from a longer, unspliced transcript in endothelial cells has been described\; however, the authenticity of this product has been questioned. Yet another less abundant GPIb beta mRNA species of 3.5 kb, expressed in nonhematopoietic tissues such as endothelium, brain and heart, was shown to result from inefficient usage of a non-consensus polyA signal in the neighboring upstream gene (SEPT5, septin 5). In the absence of polyadenylation from its own imperfect site, the SEPT5 gene produces read-through transcripts that use the consensus polyA signal of this gene.

Gene names and symbols associated with GP1BB

  • glycoprotein Ib (platelet), beta polypeptide (GP1BB) antibody
  • glycoprotein Ib platelet beta subunit (GP1BB) antibody
  • glycoprotein Ib platelet beta subunit (Gp1bb) antibody
  • glycoprotein Ib, beta polypeptide (Gp1bb) antibody
  • BDPLT1 antibody
  • BS antibody
  • CD42C antibody
  • GPIBB antibody

Protein level used designations for GP1BB

glycoprotein Ib (platelet), beta polypeptide , GP-Ib beta , antigen CD42b-beta , nuclear localization signal deleted in velocardiofacial syndrome , platelet glycoprotein Ib beta chain , GPIb-beta , GPIbB , glycoprotein Ib, beta polypeptide

416780 Gallus gallus
608234 Canis lupus familiaris
2812 Homo sapiens
116727 Rattus norvegicus
14724 Mus musculus
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