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GP1BB antibody (AA 27-147)

GP1BB Reactivity: Human WB Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN6141287
  • Target See all GP1BB Antibodies
    GP1BB (Glycoprotein Ib (Platelet), beta Polypeptide (GP1BB))
    Binding Specificity
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 27-147
    Reactivity
    • 14
    • 10
    • 2
    Human
    Host
    • 16
    • 1
    Rabbit
    Clonality
    • 16
    • 1
    Polyclonal
    Conjugate
    • 9
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This GP1BB antibody is un-conjugated
    Application
    • 9
    • 6
    • 3
    • 2
    • 2
    • 2
    • 1
    Western Blotting (WB)
    Sequence
    PAPCSCAGTL VDCGRRGLTW ASLPTAFPVD TTELVLTGNN LTALPPGLLD ALPALRTAHL GANPWRCDCR LVPLRAWLAG RPERAPYRDL RCVAPPALRG RLLPYLAEDE LRAACAPGPL C
    Cross-Reactivity
    Human, Mouse, Rat
    Characteristics
    Polyclonal Antibodies
    Purification
    Affinity purification
    Immunogen
    Recombinant fusion protein containing a sequence corresponding to amino acids 27-147 of human GP1BB (NP_000398.1).
    Isotype
    IgG
    Top Product
    Discover our top product GP1BB Primary Antibody
  • Application Notes
    WB,1:200 - 1:1000
    Restrictions
    For Research Use only
  • Format
    Liquid
    Buffer
    PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    -20 °C
    Storage Comment
    Store at -20°C. Avoid freeze / thaw cycles.
  • Target
    GP1BB (Glycoprotein Ib (Platelet), beta Polypeptide (GP1BB))
    Alternative Name
    GP1BB (GP1BB Products)
    Synonyms
    BDPLT1 antibody, BS antibody, CD42C antibody, GPIBB antibody, glycoprotein Ib (platelet), beta polypeptide antibody, glycoprotein Ib platelet beta subunit antibody, glycoprotein Ib, beta polypeptide antibody, GP1BB antibody, Gp1bb antibody
    Background
    Platelet glycoprotein Ib (GPIb) is a heterodimeric transmembrane protein consisting of a disulfide-linked 140 kD alpha chain and 22 kD beta chain. It is part of the GPIb-V-IX system that constitutes the receptor for von Willebrand factor (VWF), and mediates platelet adhesion in the arterial circulation. GPIb alpha chain provides the VWF binding site, and GPIb beta contributes to surface expression of the receptor and participates in transmembrane signaling through phosphorylation of its intracellular domain. Mutations in the GPIb beta subunit have been associated with Bernard-Soulier syndrome, velocardiofacial syndrome and giant platelet disorder. The 206 amino acid precursor of GPIb beta is synthesized from a 1.0 kb mRNA expressed in plateletes and megakaryocytes. A 411 amino acid protein arising from a longer, unspliced transcript in endothelial cells has been described, however, the authenticity of this product has been questioned. Yet another less abundant GPIb beta mRNA species of 3.5 kb, expressed in nonhematopoietic tissues such as endothelium, brain and heart, was shown to result from inefficient usage of a non-consensus polyA signal in the neighboring upstream gene (SEPT5, septin 5). In the absence of polyadenylation from its own imperfect site, the SEPT5 gene produces read-through transcripts that use the consensus polyA signal of this gene.,GP1BB,BDPLT1,BS,CD42C,GPIBB,GPIbbeta,Immunology & Inflammation,CD markers,GP1BB
    Molecular Weight
    21 kDa/43 kDa
    Gene ID
    2812
    UniProt
    P13224
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