anti-Golgi-Associated, gamma Adaptin Ear Containing, ARF Binding Protein 1 (GGA1) Antibodies

GGA1 encodes a member of the Golgi-localized, gamma adaptin ear-containing, ARF-binding (GGA) protein family. Additionally we are shipping GGA1 Proteins (4) and and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
GGA1 106039 Q8R0H9
GGA1 300066  
GGA1 26088 Q9UJY5
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Top anti-GGA1 Antibodies at antibodies-online.com

Showing 10 out of 69 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Cow Rabbit Un-conjugated WB 100 μL Log in to see 2 to 3 Days
$289.00
Details
Human Rabbit Un-conjugated IF, WB The anti-GGA1 Pab (ABIN389018) is used in Western blot to detect GGA1 in mouse kidney tissue lysate (lane 1) and Jurkat cell lysate (lane 2). A, N2a cells cotransfected with APP770 �V5 and GGA1 �myc or empty vector were immunostained for APP (Alexa488. green), GGA1 (Cy5. blue), and the Golgi marker GM130 (Cy3. red). B, The same transfection was stained for the endosomal marker EEA1 (Cy3). C, To assess cell-surface localization, APP695 �GFP and GGA1 �myc or empty vector were cotransfected and then immunostained with an Ab to the APP ectodomain on ice without permeabilization (Cy3). Cells were then fixed, permeabilized, and stained for GGA1 (Cy5). (J. Neurosci. 2006 Sep 27.26(39):9913-9922) 400 μL Log in to see 10 to 11 Days
$335.50
Details
Human Rabbit Un-conjugated EIA, WB 0.4 mL Log in to see 6 to 8 Days
$390.50
Details
Cow Rabbit Un-conjugated EIA, WB   0.1 mg Log in to see 8 to 11 Days
$619.30
Details
Human Rabbit Un-conjugated ELISA, WB 100 μg Log in to see 7 to 9 Days
$639.83
Details
Human Mouse Un-conjugated IHC (p), ELISA, WB Immunoperoxidase of monoclonal antibody to GGA1 on formalin-fixed paraffin-embedded human stomach. [antibody concentration 3 ug/ml] GGA1 monoclonal antibody (M01), clone 3F11 Western Blot analysis of GGA1 expression in K-562 . 100 μg Log in to see 11 to 12 Days
$440.00
Details
Human Mouse Un-conjugated RNAi, ELISA, WB Western blot analysis of GGA1 over-expressed 293 cell line, cotransfected with GGA1 Validated Chimera RNAi (Lane 2) or non-transfected control (Lane 1). Blot probed with GGA1 monoclonal antibody (M02), clone 1G8. GAPDH ( 36.1 kDa ) used as specificity and loading control. Detection limit for recombinant GST tagged GGA1 is approximately 0.1ng/ml as a capture antibody. 100 μg Log in to see 11 to 12 Days
$440.00
Details
Human Rabbit Un-conjugated ELISA, IP, WB Western blot using GGA1 polyclonal antibody shows detection ofbands at ~100 KDa corresponding to YFP-GGA1 fusion present in a lysate of HEK293 cells over- expressing the recombinant protein (arrowhead). Approximately 35 ug of lysate was separated on a 4-20% gel by SDS-PAGE and transferred onto nitrocellulose. After blocking the membrane was probed with the primary antibody diluted to 1:1,350. Reaction occurred overnight at 4°C followed by washes and reactionwith a 1 : 10,000 dilution of IRDye™800 conjugated Rb-a-Goat IgG [H&L] MXHu for 45 min at room temperature. 100 μg Log in to see 11 to 12 Days
$576.53
Details
Bat Rabbit Un-conjugated WB   50 μg Log in to see 7 to 9 Days
$551.83
Details
Human Rabbit Un-conjugated IHC, IHC (p), WB Immunohistochemistry-Paraffin: GGA1 Antibody [NBP2-16650] - Immunohistochemical analysis of paraffin-embedded Gastric ca, using antibody at 1:500 dilution. Western Blot: GGA1 Antibody [NBP2-16650] - Sample (30 ug of whole cell lysate) A: NT2D1 B: PC-3 C: U87-MG D: SK-N-SH 7. 5% SDS PAGE gel, diluted at 1:1000. 0.1 mL Log in to see 8 to 11 Days
$514.63
Details

Top referenced anti-GGA1 Antibodies

  1. Human Polyclonal GGA1 Primary Antibody for IF, WB - ABIN389018 : Zhai, He, Liu, Wakeham, Zhu, Li, Tang, Zhang: The interaction of the human GGA1 GAT domain with rabaptin-5 is mediated by residues on its three-helix bundle. in Biochemistry 2003 (PubMed)
    Show all 4 Pubmed References

More Antibodies against GGA1 Interaction Partners

Mouse (Murine) Golgi-Associated, gamma Adaptin Ear Containing, ARF Binding Protein 1 (GGA1) interaction partners

  1. novel protein complex composed of Rabep1 (show RABEP1 Antibodies), GGA1 and Arl3 is responsible for the sorting and targeting of the polycystin 1 (show PKD1 Antibodies) andpolycystin 2 to the cilium.

  2. GGA1 interacts with internal LRP9 (show LRP10 Antibodies) and LRP12 (show LRP12 Antibodies) DXXLL motifs.

  3. depletion of GGA1 and GGA3 (show GGA3 Antibodies) engender a rapid and robust elevation of BACE1 (show BACE Antibodies) in the acute phase after brain injury.

  4. termination of Arf1 (show ARF1 Antibodies) signals mediated through GGA require that Arf1 (show ARF1 Antibodies).GTP (show AK3 Antibodies) dissociates from GGA prior to interaction with GAP and consequent hydrolysis of GTP (show AK3 Antibodies)

  5. serine phosphorylation of BACE (show BACE Antibodies) is a physiologically relevant post-translational modification that regulates trafficking in the juxtanuclear compartment by interaction with GGA1

  6. Glut4 (show SLC2A4 Antibodies) insulin (show INS Antibodies)-responsive trafficking is mediated by GGA adaptors in mouse adipocytes

  7. the trafficking of adiponectin through its secretory pathway is dependent on GGA-coated vesicles

Human Golgi-Associated, gamma Adaptin Ear Containing, ARF Binding Protein 1 (GGA1) interaction partners

  1. full length alpha2B (show ADRA2B Antibodies)-AR associated with GGA2 (show GGA2 Antibodies) but not GGA1, its third intracellular loop was found to directly interact with both GGA1 and GGA2 (show GGA2 Antibodies). More interestingly, further mapping of interaction domains showed that the GGA1 hinge region and the GGA2 (show GGA2 Antibodies) GAE domain bound to multiple subdomains of the loop.

  2. These findings show that the AD-like phenotype of NPC (show NPC1 Antibodies) model cells can be partly reverted by promoting a non-amyloidogenic processing of APP (show APP Antibodies) through the upregulation of GGA1 supporting its preventive role against AD

  3. These data indicate that clathrin is required for the function of AP-1 (show FOSB Antibodies)- and GGA-coated carriers at the trans-Golgi network but may be dispensable for outward traffic en route to the plasma membrane.

  4. On basis of these results, propose that GGA1 facilitates LR11 (show SORL1 Antibodies) endocytic traffic and that LR11 (show SORL1 Antibodies) modulates A-beta (show SUCLA2 Antibodies) levels by promoting amyloid-beta precursor protein traffic to the endocytic recycling compartment

  5. X-ray structure of the GGA1 VHS domain alone, and in complex with the carboxy-terminal peptide of cation-independent mannose 6-phosphate receptor (show IGF2R Antibodies) containing an ACLL sequence

  6. endocytosis and intracellular transport of memapsin 2 (show BACE Antibodies), mediated by its cytosolic domain, may involve the binding of GGA1 and GGA2 (show GGA2 Antibodies)

  7. The 2.4-A crystal structure of the GAT domain of human GGA1 reveals a three-helix bundle, with a long N-terminal helical extension that is not conserved in GAT domains that do not bind ARF.

  8. X-ray crystal structures of the human GGA1-GAT domain and the complex between ARF1-GTP and the N-terminal region of the GAT domain

  9. Crystal structure of the human GGA1 GAT domain

  10. A hydrophobic surface patch on the C-terminal three-helix bundle motif of the GGA1 GAT (show GLYAT Antibodies) domain is directly involved in binding with a coiled-coil region of rabaptin-5 (show RABEP1 Antibodies).

GGA1 Antigen Profile

Protein Summary

This gene encodes a member of the Golgi-localized, gamma adaptin ear-containing, ARF-binding (GGA) protein family. Members of this family are ubiquitous coat proteins that regulate the trafficking of proteins between the trans-Golgi network and the lysosome. These proteins share an amino-terminal VHS domain which mediates sorting of the mannose 6-phosphate receptors at the trans-Golgi network. They also contain a carboxy-terminal region with homology to the ear domain of gamma-adaptins. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene.

Gene names and symbols associated with GGA1

  • putative golgi associated, gamma adaptin ear containing,arf binding protein 1 (gga1) (Smp_164030) antibody
  • golgi associated, gamma adaptin ear containing, ARF binding protein 1 (Gga1) antibody
  • golgi-associated, gamma adaptin ear containing, ARF binding protein 1 (gga1) antibody
  • golgi associated, gamma adaptin ear containing, ARF binding protein 1 (GGA1) antibody
  • 4930406E12Rik antibody
  • AU016030 antibody
  • AW209092 antibody
  • fb33h10 antibody
  • im:6912200 antibody
  • wu:fb33h10 antibody
  • zgc:101044 antibody

Protein level used designations for GGA1

golgi associated gamma adaptin ear containing arf binding protein 1 (gga1) , ADP-ribosylation factor-binding protein GGA1 , gamma-adaptin-related protein 1 , golgi-localized, gamma ear-containing, ARF-binding protein 1 , ADP-ribosylation factor binding protein 1 , gamma-adaptin related protein 1 , golgi associated, gamma adaptin ear containing, ARF binding protein 1

GENE ID SPECIES
8345265 Schistosoma mansoni
106039 Mus musculus
300066 Rattus norvegicus
798361 Danio rerio
26088 Homo sapiens
534634 Bos taurus
481266 Canis lupus familiaris
100623753 Sus scrofa
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