anti-Golgi-Associated, gamma Adaptin Ear Containing, ARF Binding Protein 2 (GGA2) Antibodies

GGA2 encodes a member of the Golgi-localized, gamma adaptin ear-containing, ARF-binding (GGA) family. Additionally we are shipping Golgi-Associated, gamma Adaptin Ear Containing, ARF Binding Protein 2 Proteins (4) and and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
GGA2 74105 Q6P5E6
GGA2 293455  
GGA2 23062 Q9UJY4
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Top anti-Golgi-Associated, gamma Adaptin Ear Containing, ARF Binding Protein 2 Antibodies at antibodies-online.com

Showing 10 out of 47 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Cow Rabbit Un-conjugated WB Host: Rabbit Target Name: GGA2 Sample Type: Placenta lysates Antibody Dilution: 1.0ug/ml 100 μL Log in to see 2 to 3 Days
$319.00
Details
Human Rabbit Un-conjugated IF, IHC, WB Western blot analysis of extracts of various cell lines, using GGA2 antibody. 100 μL Log in to see 16 Days
$366.77
Details
Mouse Rabbit Un-conjugated IHC, WB Immunohistochemistry of paraffin-embedded human kidney using GGA2 antibody at dilution of 1:200 (x400 lens) 100 μL Log in to see 13 to 14 Days
$393.25
Details
Human Rabbit Un-conjugated IF/ICC, IHC, WB Western blot analysis of extracts of various cell lines, using GGA2 antibody (ABIN5970532) at 1/1000 dilution. Immunohistochemistry of paraffin-embedded human kidney using GGA2 Antibody (ABIN5970532) at dilution of 1/200 (40x lens). 100 μL Log in to see 11 to 16 Days
$426.40
Details
Human Rabbit Un-conjugated ELISA, IHC, IHC (p) Human Kidney (formalin-fixed, paraffin-embedded) stained with GGA2 antibody ABIN214348 at 2.5 ug/ml followed by biotinylated goat anti-rabbit IgG secondary antibody ABIN481713, alkaline phosphatase-streptavidin and chromogen. Anti-GGA2 antibody IHC of human kidney. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml. 50 μg Log in to see 11 to 14 Days
$484.00
Details
Human Rabbit Un-conjugated ELISA, IHC, WB Western blot analysis of brain  lysate using GGA2 antibody. The lane on the left is treated with the antigen-specific peptide. ABIN6276589 at 1/100 staining Human breast cancer tissue by IHC-P. The sample was formaldehyde fixed and a heat mediated antigen retrieval step in citrate buffer was performed. The sample was then blocked and incubated with the antibody for 1.5 hours at 22¡ãC. An HRP conjugated goat anti-rabbit antibody was used as the secondary 100 μL Log in to see 11 to 12 Days
$390.77
Details
Human Rabbit Un-conjugated IF (p), IHC (p), WB Formalin-fixed and paraffin embedded rat brain labeled with Anti-GGA2 Polyclonal Antibody, Unconjugated  at 1:200 followed by conjugation to the secondary antibody and DAB staining Formalin-fixed and paraffin embedded rat lung carcinoma labeled with Anti-GGA2 Polyclonal Antibody, Unconjugated  at 1:200 followed by conjugation to the secondary antibody and DAB staining 100 μL Log in to see 14 to 21 Days
$317.90
Details
Horse Rabbit Un-conjugated WB 50 μg Log in to see 11 to 14 Days
$551.83
Details
Human Rabbit Un-conjugated EIA, IHC (p) 50 μg Log in to see 6 to 8 Days
$495.00
Details
Human Mouse Un-conjugated WB Western Blot analysis of GGA2 expression in transfected 293T cell line by GGA2 MaxPab polyclonal antibody.Lane1:GGA2 transfected lysate(67.43 KDa).Lane2:Non-transfected lysate. 50 μL Log in to see 11 to 12 Days
$440.00
Details

More Antibodies against Golgi-Associated, gamma Adaptin Ear Containing, ARF Binding Protein 2 Interaction Partners

Mouse (Murine) Golgi-Associated, gamma Adaptin Ear Containing, ARF Binding Protein 2 (GGA2) interaction partners

  1. GGA2 binds to the internal DXXLL motif of the LRP9

Human Golgi-Associated, gamma Adaptin Ear Containing, ARF Binding Protein 2 (GGA2) interaction partners

  1. Study shows that reduced expression of GGA3 resultes in accumulation of endocytosed EGFR within enlarged endosomes. GGA2 interacts with EGFR cytoplasmic domain to stabilize the receptor expression and promote cell growth. Finally, GGA2 was upregulated in 30.8% of human hepatocellular carcinomas and 23.3% of colorectal cancers.

  2. PI4KIIIbeta interaction with the VHS domain of GGA2 affected PI4KIIIbeta localization.

  3. full length alpha2B-AR associated with GGA2 but not GGA1, its third intracellular loop was found to directly interact with both GGA1 and GGA2. More interestingly, further mapping of interaction domains showed that the GGA1 hinge region and the GGA2 GAE domain bound to multiple subdomains of the loop.

  4. These data indicate that clathrin is required for the function of AP-1- and GGA-coated carriers at the trans-Golgi network but may be dispensable for outward traffic en route to the plasma membrane.

  5. GGA2 mediates a vital function that cannot be compensated for by GGA1and/or GGA3.

  6. endocytosis and intracellular transport of memapsin 2, mediated by its cytosolic domain, may involve the binding of GGA1 and GGA2

  7. GGA proteins function with the phosphorylated ACDL in the memasin 2-recycling pathway from endosomes to trans Golgi on the way back to the cell surface.

  8. Results demonstrate that cargo proteins contribute to the recruitment of GGA2 onto membranes and to the formation of GGA-positive clathrin-coated vesicles.

  9. These results show that the dual roles of PI4P can promote specific GGA targeting and cargo recognition at the trans-Golgi network.

  10. p56 tightly cooperates with the GGAs in the sorting of cathepsin D to lysosomes, probably by enabling the movement of GGA-containing transport carriers.

  11. GGA2 is recruited to the trans-Golgi network independently of the other Golgi-localized, gamma-ear-containing, ARF-binding proteins and is required for the efficient sorting of lysosomal enzymes

  12. GGA overexpression causes various sorting defects as measured by recycling of CD-MPR, internalization of transferrin receptor, and the subcellular localization of proteins like Tsg101, ubiquitin, and Hrs.

Golgi-Associated, gamma Adaptin Ear Containing, ARF Binding Protein 2 (GGA2) Antigen Profile

Protein Summary

This gene encodes a member of the Golgi-localized, gamma adaptin ear-containing, ARF-binding (GGA) family. This family includes ubiquitous coat proteins that regulate the trafficking of proteins between the trans-Golgi network and the lysosome. These proteins share an amino-terminal VHS domain which mediates sorting of the mannose 6-phosphate receptors at the trans-Golgi network. They also contain a carboxy-terminal region with homology to the ear domain of gamma-adaptins. This family member may play a significant role in cargo molecules regulation and clathrin-coated vesicle assembly.

Gene names and symbols associated with GGA2

  • golgi associated, gamma adaptin ear containing, ARF binding protein 2 (Gga2) antibody
  • golgi associated, gamma adaptin ear containing, ARF binding protein 2 (GGA2) antibody
  • 1200007E24Rik antibody
  • mKIAA1080 antibody
  • VEAR antibody

Protein level used designations for GGA2

ADP-ribosylation factor-binding protein GGA2 , gamma-adaptin-related protein 2 , golgi-localized, gamma ear-containing, ARF-binding protein 2 , VHS domain and ear domain of gamma-adaptin , VHS domain and ear domain-containing protein , golgi associated, gamma adaptin ear containing, ARF binding protein 2

GENE ID SPECIES
74105 Mus musculus
293455 Rattus norvegicus
23062 Homo sapiens
608555 Canis lupus familiaris
100524333 Sus scrofa
517031 Bos taurus
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