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GGA2 encodes a member of the Golgi-localized, gamma adaptin ear-containing, ARF-binding (GGA) family. Additionally we are shipping Golgi-Associated, gamma Adaptin Ear Containing, ARF Binding Protein 2 Proteins (4) and and many more products for this protein.
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GGA2 binds to the internal DXXLL motif of the LRP9 (show LRP10 Antibodies)
PI4KIIIbeta (show PI4KB Antibodies) interaction with the VHS domain of GGA2 affected PI4KIIIbeta (show PI4KB Antibodies) localization.
full length alpha2B (show ADRA2B Antibodies)-AR associated with GGA2 but not GGA1 (show GGA1 Antibodies), its third intracellular loop was found to directly interact with both GGA1 (show GGA1 Antibodies) and GGA2. More interestingly, further mapping of interaction domains showed that the GGA1 (show GGA1 Antibodies) hinge region and the GGA2 GAE domain bound to multiple subdomains of the loop.
These data indicate that clathrin is required for the function of AP-1 (show FOSB Antibodies)- and GGA-coated carriers at the trans-Golgi network but may be dispensable for outward traffic en route to the plasma membrane.
GGA2 mediates a vital function that cannot be compensated for by GGA1and/or GGA3 (show GGA3 Antibodies).
endocytosis and intracellular transport of memapsin 2 (show BACE Antibodies), mediated by its cytosolic domain, may involve the binding of GGA1 (show GGA1 Antibodies) and GGA2
Results demonstrate that cargo proteins contribute to the recruitment of GGA2 onto membranes and to the formation of GGA-positive clathrin-coated vesicles.
p56 (show IFIT1 Antibodies) tightly cooperates with the GGAs in the sorting of cathepsin D (show CTSD Antibodies) to lysosomes, probably by enabling the movement of GGA-containing transport carriers.
GGA2 is recruited to the trans-Golgi network independently of the other Golgi-localized, gamma-ear-containing, ARF-binding proteins and is required for the efficient sorting of lysosomal enzymes
GGA overexpression causes various sorting defects as measured by recycling of CD-MPR, internalization of transferrin receptor, and the subcellular localization of proteins like Tsg101, ubiquitin, and Hrs.
This gene encodes a member of the Golgi-localized, gamma adaptin ear-containing, ARF-binding (GGA) family. This family includes ubiquitous coat proteins that regulate the trafficking of proteins between the trans-Golgi network and the lysosome. These proteins share an amino-terminal VHS domain which mediates sorting of the mannose 6-phosphate receptors at the trans-Golgi network. They also contain a carboxy-terminal region with homology to the ear domain of gamma-adaptins. This family member may play a significant role in cargo molecules regulation and clathrin-coated vesicle assembly.
ADP-ribosylation factor-binding protein GGA2
, gamma-adaptin-related protein 2
, golgi-localized, gamma ear-containing, ARF-binding protein 2
, VHS domain and ear domain of gamma-adaptin
, VHS domain and ear domain-containing protein
, golgi associated, gamma adaptin ear containing, ARF binding protein 2