anti-Gremlin 2 (GREM2) Antibodies

GREM2 encodes a member of the BMP (bone morphogenic protein) antagonist family. Additionally we are shipping Gremlin 2 Kits (13) and Gremlin 2 Proteins (8) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
GREM2 289264  
GREM2 23893 O88273
GREM2 64388 Q9H772
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Top anti-Gremlin 2 Antibodies at antibodies-online.com

Showing 10 out of 49 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Delivery Price Details
Dog Rabbit Un-conjugated WB WB Suggested Anti-GREM2 Antibody Titration: 0.2-1 ug/ml ELISA Titer: 1:312500 Positive Control: 721_B cell lysate 100 μL 2 to 3 Days
$289.00
Details
Human Rabbit Un-conjugated WB Western blot analysis of Gremlin 2 expression in HEK293T (A), Raw264.7 (B), H9C2 (C) whole cell lysates. 200 μL 13 to 14 Days
$487.50
Details
Human Rabbit Un-conjugated ELISA, IHC, IHC (p) Human Prostate: Formalin-Fixed, Paraffin-Embedded (FFPE) Anti-GREM2 / Gremlin 2 antibody IHC staining of human prostate. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. 50 μL 11 to 14 Days
$484.00
Details
Human Rabbit Un-conjugated IHC, WB Western blot analysis of extracts from mouse kidney, using GREM2 antibody. ABIN6273251 at 1/100 staining Human Melanoma tissue by IHC-P. The sample was formaldehyde fixed and a heat mediated antigen retrieval step in citrate buffer was performed. The sample was then blocked and incubated with the antibody for 1.5 hours at 22°C. An HRP conjugated goat anti-rabbit antibody was used as the secondary. 100 μL 11 to 12 Days
$390.77
Details
Chicken Rabbit Un-conjugated WB 100 μL 11 to 14 Days
$551.83
Details
Human Rabbit Un-conjugated WB 100 μg 2 to 3 Days
$245.00
Details
Human Rabbit Un-conjugated ELISA, IHC (p), WB   100 μL Available
$363.46
Details
Human Rabbit Un-conjugated IHC, IHC (p), IP Human Prostate: Formalin-Fixed, Paraffin-Embedded (FFPE) 100 μL 11 to 14 Days
$903.83
Details
Human Rabbit Un-conjugated IP Immunoprecipitation of GREM2 transfected lysate using anti-GREM2 MaxPab rabbit polyclonal antibody and Protein A Magnetic Bead , and immunoblotted with GREM2 purified MaxPab mouse polyclonal antibody (B01P) . 100 μL 11 to 12 Days
$425.71
Details
Human Rabbit Un-conjugated ELISA, IHC, WB   100 μL 2 to 3 Days
$395.00
Details

More Antibodies against Gremlin 2 Interaction Partners

Zebrafish Gremlin 2 (GREM2) interaction partners

  1. Through regulation of bone morphogenetic protein signaling, GREM2 is required for cardiac laterality and atrial differentiation during embryonic development.

  2. Gremlin 2 regulates distinct roles of BMP and Endothelin 1 signaling in dorsoventral patterning of the facial skeleton.

  3. Prdc is expressed in the developing eyes and the first two pharyngeal arches, in the outer layers of the optic cup, in the arch mesenchyme expands stepwise to the remaining posterior arches, and in the somites and the the swim bladder.

Mouse (Murine) Gremlin 2 (GREM2) interaction partners

  1. Grem2 knockdown inhibited cardiomyocyte differentiation, and this effect was similar to that of Notch1 pathway inhibition in vitro. Grem2 enhances the protective effect of cardiac progenitor cells on heart function in a mouse model of myocardial infarction.

  2. Grem2 provides a molecular barrier that controls the extent of inflammatory cell infiltration by suppressing BMP2 after myocardial infarction.

  3. Grem2 expression is regulated during development and embryonic stem cell differentiation.

  4. PRDC binds heparin with high affinity and that heparin binding to PRDC interferes with BMP antagonism.

  5. We show that Tbx2 directly represses Grem1 in distal regions of the posterior limb mesenchyme allowing Bone morphogenetic protein (Bmp) signaling to abrogate Fgf4/9/17 expression in the overlying epithelium.

  6. Through a combination of biophysical and biochemical studies, the authors determined that PRDC forms biologically active dimers that potently inhibit BMP ligands.

  7. The differential regulation of Gremlin2 gene expressions by BMP2 may explain the critical function of these genes during osteoblast differentiation.

  8. ovarian PRDC expressed in granulosa cells could be involved in follicular development by antagonizing the actions of theca cell-derived Bone morphogenetic proteins

  9. We propose that PRDC might serve as a mediator to antagonize BMP-4 signaling by Wnt.

  10. PRDC expression in osteoblasts suppresses differentiation and that reduction of PRDC expression promotes osteogenesis in vitro. PRDC is accordingly identified as a potential novel therapeutic target for the regulation of bone formation.

Human Gremlin 2 (GREM2) interaction partners

  1. Grem2 increased the phosphorylation of Smad2/3 and decreased the phosphorylation of Smad1/5/8

  2. Significant associations were found between individual SNPs and SNP combinations in WNT10A, WNT10B and GREM2 SNPs with isolated tooth agenesis.

  3. TT genotype of the rs4454537 polymorphism protective against the development of osteoporosis

  4. Our study confirmed that GREM2 is a candidate gene for tooth agenesis, which mutations can explain, however, only a small fraction of the genetic contribution to the pathogenesis of this anomaly.

  5. Data show that the GREMLIN 2 (GREM2) expression during Induced Pluripotent Stem Cell (hiPS) cell cardiac differentiation follows the expression pattern of cardiac-specific genes.

  6. The structure of Grem2-GDF5 complex has revealed a number of key findings for DAN-family mediated BMP2 inhibition.

  7. This study showed that si-Grem2 increased the BMP-2-induced osteogenic differentiation of hBMSCs via the BMP-2/Smad/Runx2 pathway.

  8. The present study shows that the Grem2 heparin/HS and BMP2-binding epitopes are unique and independent, where the Grem2-BMP2 complex exhibits a significant increase in binding affinity toward heparin moieties that appear to be partially independent of the Grem2 heparin/HS-binding epitope.

  9. Gremlin 2 inhibits adipocyte differentiation through activation of Wnt/beta-catenin signaling

  10. mutations associated with tooth malformations

  11. GREM2 variants have been identified in atrial fibrillation cohort studies, demonstrating abnormalities in cardiac excitation - supra ventricular tachycardia and atrial fibrillation.

  12. The minor allele of rs4454537 is significantly associated with low bone density at the total hip of southern Chinese people. Our study further suggests GREM2 as a novel susceptibility gene for osteoporosis.

  13. Through regulation of bone morphogenetic protein signaling, GREM2 is required for cardiac laterality and atrial differentiation during embryonic development.

  14. and that a genetic variant in the FMN2/GREM2 locus influences GREM2 expression in osteoblasts and thereby trabecular number and thickness as well as fracture risk.

Gremlin 2 (GREM2) Antigen Profile

Protein Summary

This gene encodes a member of the BMP (bone morphogenic protein) antagonist family. Like BMPs, BMP antagonists contain cystine knots and typically form homo- and heterodimers. The CAN (cerberus and dan) subfamily of BMP antagonists, to which this gene belongs, is characterized by a C-terminal cystine knot with an eight-membered ring. The antagonistic effect of the secreted glycosylated protein encoded by this gene is likely due to its direct binding to BMP proteins. As an antagonist of BMP, this gene may play a role in regulating organogenesis, body patterning, and tissue differentiation.

Gene names and symbols associated with anti-Gremlin 2 (GREM2) Antibodies

  • gremlin 2, DAN family BMP antagonist (GREM2) antibody
  • gremlin 2, DAN family BMP antagonist b (grem2b) antibody
  • gremlin 2, cysteine knot superfamily (grem2) antibody
  • gremlin 2, DAN family BMP antagonist (grem2) antibody
  • gremlin 2, DAN family BMP antagonist (Grem2) antibody
  • CKTSF1B2 antibody
  • DAND3 antibody
  • Gremlin2 antibody
  • PRDC antibody
  • RGD1560008 antibody
  • zgc:112207 antibody

Protein level used designations for anti-Gremlin 2 (GREM2) Antibodies

gremlin 2, cysteine knot superfamily, homolog (Xenopus laevis) , gremlin 2, cysteine knot superfamily, homolog , gremlin-2 , protein related to DAN and cerberus homolog , gremlin 2, cysteine knot superfamily , gremlin 2 homolog, cysteine knot superfamily , Gremlin1 , cysteine knot superfamily 1, BMP antagonist 2 , protein related to DAN and cerberus , DAN domain family member 3

GENE ID SPECIES
421507 Gallus gallus
469727 Pan troglodytes
490367 Canis lupus familiaris
550399 Danio rerio
100194915 Salmo salar
100528649 Ictalurus punctatus
289264 Rattus norvegicus
23893 Mus musculus
64388 Homo sapiens
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