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The protein encoded by GAP43 has been termed a 'growth' or 'plasticity' protein because it is expressed at high levels in neuronal growth cones during development and axonal regeneration. Additionally we are shipping GAP43 Kits (48) and GAP43 Proteins (20) and many more products for this protein.
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Chicken Polyclonal GAP43 Primary Antibody for ICC, IHC (fro) - ABIN152489
Ferguson, Muir: MMP-2 and MMP-9 increase the neurite-promoting potential of schwann cell basal laminae and are upregulated in degenerated nerve. in Molecular and cellular neurosciences 2000
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Cat (Feline) Polyclonal GAP43 Primary Antibody for ICC, IF - ABIN448340
Benowitz, Goldberg, Madsen, Soni, Irwin: Inosine stimulates extensive axon collateral growth in the rat corticospinal tract after injury. in Proceedings of the National Academy of Sciences of the United States of America 1999
Show all 25 Pubmed References
Chicken Polyclonal GAP43 Primary Antibody for ICC, IF - ABIN314178
Zuo, Neubauer, Graham, Krekoski, Ferguson, Muir: Regeneration of axons after nerve transection repair is enhanced by degradation of chondroitin sulfate proteoglycan. in Experimental neurology 2002
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Chicken Polyclonal GAP43 Primary Antibody for IHC (fro), IHC (p) - ABIN314179
Woolf, Reynolds, Molander, OBrien, Lindsay, Benowitz: The growth-associated protein GAP-43 appears in dorsal root ganglion cells and in the dorsal horn of the rat spinal cord following peripheral nerve injury. in Neuroscience 1990
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Human Polyclonal GAP43 Primary Antibody for IHC (p), WB - ABIN3043685
Chen, Wei, Nie, Lin, Tian, Liu, Yu, Cheng, Yan, Wang, Liu, Deng, Lai, Zhou, Zhang, Lin, Chen: ?-Asarone prevents autophagy and synaptic loss by reducing ROCK expression in asenescence-accelerated prone 8 mice. in Brain research 2014
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Human Monoclonal GAP43 Primary Antibody for IF, WB - ABIN968792
Chapman, Estep, Storm: Palmitylation of neuromodulin (GAP-43) is not required for phosphorylation by protein kinase C. in The Journal of biological chemistry 1993
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Human Monoclonal GAP43 Primary Antibody for IF, WB - ABIN968793
Cimler, Andreasen, Andreasen, Storm: P-57 is a neural specific calmodulin-binding protein. in The Journal of biological chemistry 1985
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Human Monoclonal GAP43 Primary Antibody for IHC (fro), IHC (p) - ABIN3043645
Nie, Deng, Yang, Liu, Zhang, Wen: Axonal regeneration and remyelination evaluation of chitosan/gelatin-based nerve guide combined with transforming growth factor-?1 and Schwann cells. in Cell biochemistry and biophysics 2014
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Chicken Monoclonal GAP43 Primary Antibody for IHC, IHC (fro) - ABIN448371
Murakami, Ito, Hagiwara, Kobayashi, Hoshikawa, Takagi, Kojima, Tamiya-Koizumi, Sobue, Ichihara, Suzuki, Banno, Nozawa, Murate: Sphingosine kinase 1/S1P pathway involvement in the GDNF-induced GAP43 transcription. in Journal of cellular biochemistry 2011
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Cat (Feline) Polyclonal GAP43 Primary Antibody for IHC (fro), IF - ABIN2473748
Boldt, Kling, Moosdorf, Hempelmann: Enoximone treatment of impaired myocardial function during cardiac surgery: combined effects with epinephrine. in Journal of cardiothoracic anesthesia 1992
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The expression pattern of the regeneration-associated protein GAP-43 suggested a lower regenerative capacity in nigral dopaminergic neurons of Parkinson disease patients.
Findings show high level of both YKL-40 (show CHI3L1 Antibodies) and GAP-43 in CSF (show CSF2 Antibodies) of older women with suicidal ideation which suggest that a disrupted synaptic glial functioning and inflammation may be related to the aetiology of suicidal ideation in older adults.
associations of neuromodulin and neurogranin (show NRGN Antibodies) to Alzheimer's disease
Copy-number variations are enriched for GAP43 and other neurodevelopmental genes in children with developmental coordination disorder.
Downregulation of GAP43 promotes gliomas.
The peripheral neuropathies lead to an initial increase in GAP-43 gene expression as a potential mechanism of regeneration, which is not sustained in neuropathies of long duration.
Results show that PKC (show PRRT2 Antibodies)-dependent phosphorylation of GAP43 plays a critical role in regulating postsynaptic gephyrin (show GPHN Antibodies) aggregation in developing GABAergic synapses.
increased expression of TH and GAP43 might be a molecular mechanism for left atrial myoelectricity remodeling of aging atrial fibrillation patients, which might be potential therapeutic targets of atrial fibrillation.
GAP43 is seemingly a highly sensitive marker for peripheral nerve sheath tumors
The results showed that the decreased GAP-43 levels induced by glutamate (show GRIN1 Antibodies) could be partially reversed by the presence of NRG-1beta
hnRNP (show HNRNPH2 Antibodies)-Q1-mediated repression of Gap-43 mRNA translation provides an additional mechanism for regulating GAP-43 expression and function and may be critical for neuronal development.
The GASP (show GPRASP1 Antibodies)-43 is involves in the orientation of cell division by interacting with Galphai.
Trimethyltin decreased synaptophysin (show SYP Antibodies) but not GAP-43 expression in the mouse hippocampus.
Antiretroviral drugs may recruit the HuD (show ELAVL4 Antibodies)-GAP43 pathway, potentially contributing to a response to the antiretroviral neuronal toxicity.
KSRP (show KHSRP Antibodies) modulation of GAP-43 mRNA stability restricts axonal outgrowth in embryonic hippocampal neurons.
these findings suggest that GAP-43 is dynamically involved in early postnatal and adult hippocampal neurogenesis and synaptic connectivity, possibly contributing to the GAP-43+/- behavioral phenotype.
In this review, GAP-43 in vivo knockdown in olivary neurons leads to the atrophy of their climbing fibers and a reduction in the ability to sprout toward surrounding denervated Purkinje cells.
GAP-43 is required to sustain synaptic stability and promote the initiation of axonal regrowth
In vitro results indicated that GAP43 is indeed expressed in both myoblasts and differentiating myotubes, and its cellular localization changes dramatically during maturation.
Initial emergence of hollows in the somatosensory cortex is no different between GAP43 heterozygous mice and nonheterozygous littermate controls; however, the emergence of sides and septa (show SEPT2 Antibodies) is delayed by 2 days.
these results and GAP43 structural features, support an involvement of the protein in the dynamic intracellular Ca2 (show CA2 Antibodies)+ homeostasis, a common conserved role among the different species.
The results implicate the GAP43 pathway as part of an F-actin based mechanism that both stabilizes new synapses and initiates new branches near effective synapses.
The present data strongly suggest that phospho-GAP43 plays an active role in both the early and late stages of optic nerve regeneration in fish.
Both the synthetic N-terminal peptide GAP-43(1-40) and the brain-derived fragment GAP-43-3 preserved the ability to oligomerize under the action of acidic phospholipids and SDS (show SDS Antibodies).
These results indicated the interaction of GAP-43 and Galpha(o (show GNAO1 Antibodies)) could accelerate conversion of depalmitoylated Galpha(o (show GNAO1 Antibodies)) but not palmitoylated Galpha(o (show GNAO1 Antibodies)) from oligomers to monomers, so as to increase the GTPgammaS binding activity of Galpha(o (show GNAO1 Antibodies)).
The protein encoded by this gene has been termed a 'growth' or 'plasticity' protein because it is expressed at high levels in neuronal growth cones during development and axonal regeneration. This protein is considered a crucial component of an effective regenerative response in the nervous system. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.
axonal membrane protein GAP-43
, calmodulin-binding protein P-57
, growth-associated protein 43
, nerve growth-related peptide GAP43
, neural phosphoprotein B-50
, neuron growth-associated protein 43
, protein F1
, brain abundant, membrane attached signal protein 2
, growth accentuating protein 43
, growth associated protein 43 b
, growth associated protein 43 a
, Axonal membrane protein GAP-43
, growth-associated polypeptide