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GREB1 is an estrogen-responsive gene that is an early response gene in the estrogen receptor-regulated pathway.
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A significant association between GREB1L variants and BKA.
greb1 mutation reduces pituitary hormone (show CGA Antibodies) expression and causes significant growth defects.
Whole exome sequence analysis of two families with renal agenesis identified a single candidate gene, GREB1L. Data implicates GREB1L as a coactivator for RARs (show RARS Antibodies).
Which were rescued by wild-type human GREB1L mRNA.
the GREB1 region on chromosome 2p25.1 and the GREB1 gene may play a role in endometriosis risk
GREB1 is a critical mediator of both the estrogen-stimulated proliferation of breast cancer cells and the androgen-stimulated proliferation of prostate cancer cells
The expression of Greb1 was up-regulated in mouse tumors treated with E2 and was overexpressed in human ovarian cancers relative to human ovarian surface epithelium, suggesting a role for GREB1 in human ovarian tumor progression.
RAD54B and GREB1 gene polymorphisms may not be associated with PCOS in the Han Chinese population.
GREB1 is one of the central estrogen-specific ER cofactors, where it functions to mediate interactions between the ER and additional proteins.
GREB1 alpha mRNA/protein expression levels were increased in ectopic tissue in peritoneal endometriosis.
in ER-positive breast cancer cells, LRH-1 (show NR5A2 Antibodies) promotes cell proliferation by enhancing ERalpha (show ESR1 Antibodies) mediated transcription of target genes such as GREB-1
This gene is an estrogen-responsive gene that is an early response gene in the estrogen receptor-regulated pathway. It is thought to play an important role in hormone-responsive tissues and cancer. Three alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.
, gene regulated by estrogen in breast cancer
, gene regulated in breast cancer 1 protein