anti-Heat Shock Factor Protein 1 (HSF1) Antibodies

The product of HSF1 is a heat-shock transcription factor. Additionally we are shipping HSF1 Kits (59) and HSF1 Proteins (15) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
HSF1 15499 P38532
HSF1 3297 Q00613
HSF1 79245  
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Top anti-HSF1 Antibodies at antibodies-online.com

Showing 10 out of 595 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Cow Rat Un-conjugated ELISA, GS, ICC, IF, IHC, IP, WB HSF1 (10H8), HeLa cells mitosis 100 μg Log in to see 3 to 4 Days
$365.30
Details
Human Rabbit Un-conjugated ICC, IF, WB Immunocytochemistry/Immunofluorescence analysis using Rabbit Anti-HSF1 Polyclonal Antibody . Tissue: Heat Shocked HeLa Cells. Species: Human. Fixation: 2% Formaldehyde for 20 min at RT. Primary Antibody: Rabbit Anti-HSF1 Polyclonal Antibody  at 1:100 for 12 hours at 4°C. Secondary Antibody: R-PE Goat Anti-Rabbit (yellow) at 1:200 for 2 hours at RT. Counterstain: DAPI (blue) nuclear stain at 1:40000 for 2 hours at RT. Localization: Cytoplasm. Nucleus. Magnification: 100x. (A) DAPI (blue) nuclear stain. (B) Anti-HSF1 Antibody. (C) Composite. Heat Shocked at 42°C for 1h. Immunocytochemistry/Immunofluorescence analysis using Rabbit Anti-HSF1 Polyclonal Antibody . Tissue: Heat Shocked HeLa Cells. Species: Human. Fixation: 2% Formaldehyde for 20 min at RT. Primary Antibody: Rabbit Anti-HSF1 Polyclonal Antibody  at 1:100 for 12 hours at 4°C. Secondary Antibody: FITC Goat Anti-Rabbit (green) at 1:200 for 2 hours at RT. Counterstain: DAPI (blue) nuclear stain at 1:40000 for 2 hours at RT. Localization: Cytoplasm. Nucleus. Magnification: 20x. (A) DAPI (blue) nuclear stain. (B) Anti-HSF1 Antibody. (C) Composite. Heat Shocked at 42°C for 1h. 100 μg Log in to see 3 to 4 Days
$426.40
Details
Cow Rabbit Un-conjugated WB WB Suggested Anti-HSF1 Antibody Titration:  0.06125ug/ml  ELISA Titer:  1:62500  Positive Control:  SP2/0 cell lysate 100 μL Log in to see 2 to 3 Days
$289.00
Details
Human Rabbit Un-conjugated ICC, IHC (fro), IHC (p), WB Anti-HSF1 antibody, IHC(P) IHC(P): Human Mammary Cancer Tissue Anti-HSF1 antibody, Western blotting Lane 1: HELA Cell Lysate Lane 2: 293T Cell Lysate Lane 3: RAJI Cell Lysate Lane 4: A549 Cell Lysate Lane 5: MCF-7 Cell Lysate 100 μg Log in to see 4 to 6 Days
$280.00
Details
Cow Rat Un-conjugated ELISA, GS, ICC, IF, IHC, IP, WB Immunocytochemistry/Immunofluorescence analysis using Rat Anti-HSF1 Monoclonal Antibody, Clone 4B4 . Tissue: Heat Shocked HeLa Cells. Species: Human. Fixation: 2% Formaldehyde for 20 min at RT. Primary Antibody: Rat Anti-HSF1 Monoclonal Antibody  at 1:100 for 12 hours at 4°C. Secondary Antibody: R-PE Goat Anti-Rat (yellow) at 1:200 for 2 hours at RT. Counterstain: DAPI (blue) nuclear stain at 1:40000 for 2 hours at RT. Localization: Cytoplasm. Localizes to the nucleus upon activation. Magnification: 100x. (A) DAPI (blue) nuclear stain. (B) Anti-HSF1 Antibody. (C) Composite. Heat Shocked at 42°C for 1h. Immunohistochemistry analysis using Rat Anti-HSF1 Monoclonal Antibody, Clone 4B4 . Tissue: Breast carcinoma. Species: Human. Fixation: 10% Formalin Solution for 20 hours at RT. Primary Antibody: Rat Anti-HSF1 Monoclonal Antibody  at 1:2000 for 40 min. Secondary Antibody: Dako labeled Polymer HRP Anti-rat IgG, DAB Chromogen (brown) (Dako Envision+ System) for 30 min at RT. Counterstain: Mayer's Hematoxylin (purple/blue) nuclear stain for 1 minute at RT. Localization: Nuclear. Magnification: 100X. Courtesy of: Dr. Sandro Santagata, Harvard Medical School. 100 μg Log in to see 3 to 4 Days
$453.70
Details
Human Rabbit HRP ICC, IF, WB Immunocytochemistry/Immunofluorescence analysis using Rabbit Anti-HSF1 Polyclonal Antibody . Tissue: Heat Shocked HeLa Cells. Species: Human. Fixation: 2% Formaldehyde for 20 min at RT. Primary Antibody: Rabbit Anti-HSF1 Polyclonal Antibody  at 1:100 for 12 hours at 4°C. Secondary Antibody: R-PE Goat Anti-Rabbit (yellow) at 1:200 for 2 hours at RT. Counterstain: DAPI (blue) nuclear stain at 1:40000 for 2 hours at RT. Localization: Cytoplasm. Nucleus. Magnification: 100x. (A) DAPI (blue) nuclear stain. (B) Anti-HSF1 Antibody. (C) Composite. Heat Shocked at 42°C for 1h. Immunocytochemistry/Immunofluorescence analysis using Rabbit Anti-HSF1 Polyclonal Antibody . Tissue: Heat Shocked HeLa Cells. Species: Human. Fixation: 2% Formaldehyde for 20 min at RT. Primary Antibody: Rabbit Anti-HSF1 Polyclonal Antibody  at 1:100 for 12 hours at 4°C. Secondary Antibody: FITC Goat Anti-Rabbit (green) at 1:200 for 2 hours at RT. Counterstain: DAPI (blue) nuclear stain at 1:40000 for 2 hours at RT. Localization: Cytoplasm. Nucleus. Magnification: 20x. (A) DAPI (blue) nuclear stain. (B) Anti-HSF1 Antibody. (C) Composite. Heat Shocked at 42°C for 1h. 100 μg Log in to see 3 to 4 Days
$471.90
Details
Human Rabbit FITC ICC, IF, WB Immunocytochemistry/Immunofluorescence analysis using Rabbit Anti-HSF1 Polyclonal Antibody . Tissue: Heat Shocked HeLa Cells. Species: Human. Fixation: 2% Formaldehyde for 20 min at RT. Primary Antibody: Rabbit Anti-HSF1 Polyclonal Antibody  at 1:100 for 12 hours at 4°C. Secondary Antibody: R-PE Goat Anti-Rabbit (yellow) at 1:200 for 2 hours at RT. Counterstain: DAPI (blue) nuclear stain at 1:40000 for 2 hours at RT. Localization: Cytoplasm. Nucleus. Magnification: 100x. (A) DAPI (blue) nuclear stain. (B) Anti-HSF1 Antibody. (C) Composite. Heat Shocked at 42°C for 1h. Immunocytochemistry/Immunofluorescence analysis using Rabbit Anti-HSF1 Polyclonal Antibody . Tissue: Heat Shocked HeLa Cells. Species: Human. Fixation: 2% Formaldehyde for 20 min at RT. Primary Antibody: Rabbit Anti-HSF1 Polyclonal Antibody  at 1:100 for 12 hours at 4°C. Secondary Antibody: FITC Goat Anti-Rabbit (green) at 1:200 for 2 hours at RT. Counterstain: DAPI (blue) nuclear stain at 1:40000 for 2 hours at RT. Localization: Cytoplasm. Nucleus. Magnification: 20x. (A) DAPI (blue) nuclear stain. (B) Anti-HSF1 Antibody. (C) Composite. Heat Shocked at 42°C for 1h. 100 μg Log in to see 3 to 4 Days
$477.10
Details
Human Rabbit Alkaline Phosphatase (AP) ICC, IF, WB Immunocytochemistry/Immunofluorescence analysis using Rabbit Anti-HSF1 Polyclonal Antibody . Tissue: Heat Shocked HeLa Cells. Species: Human. Fixation: 2% Formaldehyde for 20 min at RT. Primary Antibody: Rabbit Anti-HSF1 Polyclonal Antibody  at 1:100 for 12 hours at 4°C. Secondary Antibody: R-PE Goat Anti-Rabbit (yellow) at 1:200 for 2 hours at RT. Counterstain: DAPI (blue) nuclear stain at 1:40000 for 2 hours at RT. Localization: Cytoplasm. Nucleus. Magnification: 100x. (A) DAPI (blue) nuclear stain. (B) Anti-HSF1 Antibody. (C) Composite. Heat Shocked at 42°C for 1h. Immunocytochemistry/Immunofluorescence analysis using Rabbit Anti-HSF1 Polyclonal Antibody . Tissue: Heat Shocked HeLa Cells. Species: Human. Fixation: 2% Formaldehyde for 20 min at RT. Primary Antibody: Rabbit Anti-HSF1 Polyclonal Antibody  at 1:100 for 12 hours at 4°C. Secondary Antibody: FITC Goat Anti-Rabbit (green) at 1:200 for 2 hours at RT. Counterstain: DAPI (blue) nuclear stain at 1:40000 for 2 hours at RT. Localization: Cytoplasm. Nucleus. Magnification: 20x. (A) DAPI (blue) nuclear stain. (B) Anti-HSF1 Antibody. (C) Composite. Heat Shocked at 42°C for 1h. 100 μg Log in to see 3 to 4 Days
$479.70
Details
Human Rabbit Biotin ICC, IF, WB Immunocytochemistry/Immunofluorescence analysis using Rabbit Anti-HSF1 Polyclonal Antibody . Tissue: Heat Shocked HeLa Cells. Species: Human. Fixation: 2% Formaldehyde for 20 min at RT. Primary Antibody: Rabbit Anti-HSF1 Polyclonal Antibody  at 1:100 for 12 hours at 4°C. Secondary Antibody: R-PE Goat Anti-Rabbit (yellow) at 1:200 for 2 hours at RT. Counterstain: DAPI (blue) nuclear stain at 1:40000 for 2 hours at RT. Localization: Cytoplasm. Nucleus. Magnification: 100x. (A) DAPI (blue) nuclear stain. (B) Anti-HSF1 Antibody. (C) Composite. Heat Shocked at 42°C for 1h. Immunocytochemistry/Immunofluorescence analysis using Rabbit Anti-HSF1 Polyclonal Antibody . Tissue: Heat Shocked HeLa Cells. Species: Human. Fixation: 2% Formaldehyde for 20 min at RT. Primary Antibody: Rabbit Anti-HSF1 Polyclonal Antibody  at 1:100 for 12 hours at 4°C. Secondary Antibody: FITC Goat Anti-Rabbit (green) at 1:200 for 2 hours at RT. Counterstain: DAPI (blue) nuclear stain at 1:40000 for 2 hours at RT. Localization: Cytoplasm. Nucleus. Magnification: 20x. (A) DAPI (blue) nuclear stain. (B) Anti-HSF1 Antibody. (C) Composite. Heat Shocked at 42°C for 1h. 100 μg Log in to see 3 to 4 Days
$482.30
Details
Human Rabbit PE ICC, IF, WB Immunocytochemistry/Immunofluorescence analysis using Rabbit Anti-HSF1 Polyclonal Antibody . Tissue: Heat Shocked HeLa Cells. Species: Human. Fixation: 2% Formaldehyde for 20 min at RT. Primary Antibody: Rabbit Anti-HSF1 Polyclonal Antibody  at 1:100 for 12 hours at 4°C. Secondary Antibody: R-PE Goat Anti-Rabbit (yellow) at 1:200 for 2 hours at RT. Counterstain: DAPI (blue) nuclear stain at 1:40000 for 2 hours at RT. Localization: Cytoplasm. Nucleus. Magnification: 100x. (A) DAPI (blue) nuclear stain. (B) Anti-HSF1 Antibody. (C) Composite. Heat Shocked at 42°C for 1h. Immunocytochemistry/Immunofluorescence analysis using Rabbit Anti-HSF1 Polyclonal Antibody . Tissue: Heat Shocked HeLa Cells. Species: Human. Fixation: 2% Formaldehyde for 20 min at RT. Primary Antibody: Rabbit Anti-HSF1 Polyclonal Antibody  at 1:100 for 12 hours at 4°C. Secondary Antibody: FITC Goat Anti-Rabbit (green) at 1:200 for 2 hours at RT. Counterstain: DAPI (blue) nuclear stain at 1:40000 for 2 hours at RT. Localization: Cytoplasm. Nucleus. Magnification: 20x. (A) DAPI (blue) nuclear stain. (B) Anti-HSF1 Antibody. (C) Composite. Heat Shocked at 42°C for 1h. 100 μg Log in to see 3 to 4 Days
$483.60
Details

Top referenced anti-HSF1 Antibodies

  1. Human HSF1 Primary Antibody for IHC - ABIN966305 : Rafiee, Theriot, Nelson, Heidemann, Kanaa, Horowitz, Rogaczewski, Johnson, Ali, Shaker, Binion: Human esophageal microvascular endothelial cells respond to acidic pH stress by PI3K/AKT and p38 MAPK-regulated induction of Hsp70 and Hsp27. in American journal of physiology. Cell physiology 2006 (PubMed)
    Show all 4 Pubmed References

  2. Human Polyclonal HSF1 Primary Antibody for IHC - ABIN966306 : Takaki, Fujimoto, Sugahara, Nakahari, Yonemura, Tanaka, Hayashida, Inouye, Takemoto, Yamashita, Nakai: Maintenance of olfactory neurogenesis requires HSF1, a major heat shock transcription factor in mice. in The Journal of biological chemistry 2006 (PubMed)
    Show all 4 Pubmed References

  3. Human Polyclonal HSF1 Primary Antibody for ELISA, WB - ABIN545265 : Wang, Grammatikakis, Siganou, Calderwood: Regulation of molecular chaperone gene transcription involves the serine phosphorylation, 14-3-3 epsilon binding, and cytoplasmic sequestration of heat shock factor 1. in Molecular and cellular biology 2003 (PubMed)
    Show all 3 Pubmed References

  4. Human Polyclonal HSF1 Primary Antibody for IHC - ABIN966307 : Jolly, Usson, Morimoto: Rapid and reversible relocalization of heat shock factor 1 within seconds to nuclear stress granules. in Proceedings of the National Academy of Sciences of the United States of America 1999 (PubMed)
    Show all 2 Pubmed References

  5. Human Polyclonal HSF1 Primary Antibody for ELISA, WB - ABIN561373 : Scott, Nogueira, Heffernan, van Doorn, Dhakal, Hanna, Min, Jaskelioff, Xiao, Wu, Cameron, Perry, Zeid, Feinberg, Kim, Vande Woude, Granter, Bosenberg, Chu, DePinho, Rimm, Chin: Proinvasion metastasis drivers in early-stage melanoma are oncogenes. in Cancer cell 2011 (PubMed)
    Show all 2 Pubmed References

  6. Human Polyclonal HSF1 Primary Antibody for IF (p), IHC (p) - ABIN703466 : Evert, Frau, Tomasi, Latte, Simile, Seddaiu, Zimmermann, Ladu, Staniscia, Brozzetti, Solinas, Dombrowski, Feo, Pascale, Calvisi: Deregulation of DNA-dependent protein kinase catalytic subunit contributes to human hepatocarcinogenesis development and has a putative prognostic value. in British journal of cancer 2013 (PubMed)

  7. Human Polyclonal HSF1 Primary Antibody for IHC, ELISA - ABIN1532015 : Tamaru, Hattori, Ninomiya, Kawamura, Varès, Honda, Mishra, Wang, Benjamin, Sassone-Corsi, Ozawa, Takamatsu: ROS Stress Resets Circadian Clocks to Coordinate Pro-Survival Signals. in PLoS ONE 2013 (PubMed)

  8. Human Polyclonal HSF1 Primary Antibody for ICC, IHC (fro) - ABIN3044216 : Liao, Xue, Zhang, Feng, Liu, Zhang: Higher heat shock factor 1 expression in tumor stroma predicts poor prognosis in esophageal squamous cell carcinoma patients. in Journal of translational medicine 2016 (PubMed)

  9. Human Polyclonal HSF1 Primary Antibody for ICC, IF - ABIN2482061 : Asai, Kawashima, Katagiri, Takeuchi, Tohnai, Ohtsuka: Protective effect of a molecular chaperone inducer, paeoniflorin, on the HCl- and ethanol-triggered gastric mucosal injury. in Life sciences 2011 (PubMed)
    Show all 12 Pubmed References

  10. Human Polyclonal HSF1 Primary Antibody for IF (p), IHC (p) - ABIN703676 : Zhang, He, Lu, Bian, Yang, Fu, Wu, Li: HSF1 Relieves Amyloid-?-Induced Cardiomyocytes Apoptosis. in Cell biochemistry and biophysics 2015 (PubMed)

More Antibodies against HSF1 Interaction Partners

Caenorhabditis elegans (C. elegans) Heat Shock Factor Protein 1 (HSF1) interaction partners

  1. autophagy contributes to stress resistance and hormesis, and reveal a requirement for autophagy in HSF-1-regulated functions in the heat-shock response, proteostasis and ageing.

  2. Heat shock transcription factor HSF-1 (HSF-1) is required for the learned avoidance behavior of toward Pseudomonas aeruginosa strain PA14 .

  3. a critical role for autophagy in C. elegans stress resistance and hormesis, and reveal a requirement for autophagy in HSF-1 regulated functions in the heat-shock response, proteostasis, and aging.

  4. xyloketal derivatives bound to the DNA binding domain of HSF-1, promoted the conformation of HSF-1, thus strengthened the interaction between the HSF-1 and related DNA. ALA-67, ASN-74 and LYS-80 of binding region might be the key amino residues during the interaction.

  5. These functions of HPK-1/HSF-1 undergo rapid down-regulation once animals reach reproductive maturity. We show that HPK-1 fortifies proteostasis and extends longevity by an additional independent mechanism: induction of autophagy.

  6. Diminution in phenotypic variation for both gene expression and life span at 25 degrees C may be a consequence of low level hsf-1-dependent expression of HSP-16.2 and other chaperones at the higher temperature.

  7. We demonstrate that while DAF-16/FOXO is dispensable, the age-dependent suppression of cilia phenotypes in IFT mutants requires cell-autonomous functions of the HSF1 heat shock factor and the Hsp90 chaperone

  8. HSF-1 is a codeterminant of both alcohol and nicotine sensitivity in C. elegans and that this phenotype requires the small HSP, HSP-16.48. HSP-16.48 function in drug sensitivity is unrelated to a chaperone action during the heat shock stress response.

  9. Heat-stress-enhanced ascaroside production appears to be mediated at least in part by HSF-1, which seems to be important in adaptation strategies for coping with heat stress in this nematode.

  10. FUdR treatment can modulate the HSR and proteostasis, and should be used with caution when used to inhibit reproduction.

  11. Excitation of the AFD thermosensory neurons is sufficient to activate HSF1 in another cell, even in the absence of temperature increase. Excitation of the AFD thermosensory neurons enhances serotonin release.

  12. hsf-1 RNAi suppressed the restoration of thrashing reduced by heat stress. In contrast, hsf-1 knockdown cancelled prevention of movement reduction in a daf-2 mutant, but didn't suppress thrashing restoration in daf-2 mutant.

  13. we engaged C. elegans mutants and identified that the p38 MAPK signaling, insulin/IGF-1 signaling (IIS), and HSF-1 play pivotal roles in the WCESP-mediated host immune response

  14. HSF-1 has a prominent role in cytoskeletal integrity, ensuring cellular function during stress and aging. Overexpression of pat-10 increased actin filament stability, thermotolerance, and longevity, indicating that in addition to chaperone regulation, HSF-1 has a prominent role in cytoskeletal integrity, ensuring cellular function during stress and aging.

  15. HSF-1 represses the expression of daf-7 encoding a TGF-beta ligand, to induce young larvae to enter the dauer stage, a developmentally arrested, non-feeding, highly stress-resistant, long-lived larval form triggered by crowding and starvation.

  16. required for daf-2-insulin/IGF-1 receptor mutations to extend life-span

  17. downstream transcription factors, heat shock factor 1, and DAF-16 regulate opposing disaggregation and aggregation activities to promote cellular survival in response to constitutive toxic Abeta(1-42) aggregation

  18. Increased temperature results in the activation of a conserved pathway involving the heat-shock (HS) transcription factor (HSF)-1 that enhances immunity in the invertebrate Caenorhabditis elegans.

  19. HSF-1 has a role in enhancing immunity to bacteria in Caenorhabditis elegans [review]

Mouse (Murine) Heat Shock Factor Protein 1 (HSF1) interaction partners

  1. Variations in brain defects result from cellular mosaicism in the activation of Hsf1 heat shock signaling.

  2. Downregulation of miR-199b-5p induced differentiation of Bone-marrow mesenchymal stem cells toward cardiomyocyte-like cells partly via the HSF1/HSP70 signaling pathway.

  3. RIP140 is a co-repressor of HSF1, and it regulates neuronal stress response.

  4. The results collectively suggest that in the pressure overload heart failure model, HSF1 promoted formation of macrophages by inducing upregulation of HIF-1 expression, through which heart failure was ameliorated.

  5. These results provide new insight into HSF1 as a novel host factor for dengue virus infection through its role in facilitating autophagy-regulated viral replication in the brains.

  6. HSF1 activity is decreased in fibrotic hearts. HSF1 inhibits phosphorylation and nuclear distribution of Smad3 via direct binding to Smad3. Active Smad3 blocks the anti-fibrotic effect of HSF1.

  7. the expression level of NFATc2, miR-208b and miR-499 suggested that these responses were suppressed in HSF1-null mice

  8. identify 4 huntingtin-targeting miRNAs viz. miR-125b, miR-146a, miR-150 and miR-214 as candidate miRNAs responsible for observed inhibitory effect of HSF1 on huntingtin expression.

  9. HSF1 plays an important role in the occurrence of UVR-B-induced cataracts, possibly via regulation of HSPs such as HSP25.

  10. Targeted deletion of HSF1 results in changes of locomotor function associated with changes in cerebellar calbindin protein levels. These findings suggest a role of HSF1 in regular Purkinje cell calcium homeostasis.

  11. this study shows that HSF1 overexpression protects against TDP-43 pathology by upregulation of chaperones, especially HSP70, rather than enhancing autophagy

  12. Acetylation of the protein triggers TDP-43 pathology in cultured cells and mouse skeletal muscle, which can be cleared through an HSF1-dependent chaperone mechanism that disaggregates the protein.

  13. These findings provide insight into the role of HSF1 in Leydig cell steroidogenesis, suggesting that it maintains cholesterol transport by recovering StAR under chronic heat stress.

  14. In mammalian cell lines, only heat shock-induced but not basal expression of chaperones is dependent on the mammalian Hsf1 homolog.

  15. Upregulating HSF1 relieves the tau toxicity in N2a-TauRD DeltaK280 by reducing CHOP and increasing HSP70 a5 (BiP/GRP78). Our work reveals how the bidirectional crosstalk between the two stress response systems promotes early tau pathology and identifies HSF1 being one likely key player in both systems.

  16. HSF1 translationally augments the proteotoxic stress response.

  17. HSF1 as a central regulator of cellular bioenergetics.

  18. have demonstrated that the levels of HSF1 and heat shock proteins are significantly reduced in affected neuronal tissues from a TDP-43 transgenic mouse model of amyotrophic lateral sclerosis and patients with sporadic amyotrophic lateral sclerosis.

  19. HSF-1 ablation not only eliminates heat shock response, but it also transcriptionally up-regulates CYP7A1 and MDR1/P-gp axis in WD-diet fed HSF-1(-/-)/LDLr(-/-) mice to reduce atherosclerosis.

  20. Role of HSF1 in heart failure.HSF1 up-regulation of AC6.

Human Heat Shock Factor Protein 1 (HSF1) interaction partners

  1. HSF1 may be closely associated with the proliferation and motility of gastric cancer cells and poor prognosis of patients with gastric cancer. Accordingly, HSF1 could serve as a prognostic marker for gastric cancer.

  2. HSF1 positively regulates the transcription of latent HIV

  3. A strong reduction in heat shock transcription factor 1 (HSF1) levels was evident in Huntington's Disease (HD).

  4. Variations in brain defects result from cellular mosaicism in the activation of Hsf1 heat shock signaling.

  5. Studies indicate that heat shock factor 1 (HSF1) acts in diverse stress-induced cellular processes and molecular mechanisms.

  6. In response to DNA damage, activated and auto-poly-ADP-ribosylated PARP1 dissociates from HSF1-PARP13, and redistributes to DNA lesions and DNA damage-inducible gene loci.

  7. Overexpressed HSF1 triggers pre-mRNA 3' processing in cancers.

  8. High HSF1 expression in tumor tissues may be a prognostic biomarker in patients with intrahepatic cholangiocarcinoma.

  9. Studies suggest that heat shock factor 1 (HSF1) serves to integrate diverse biological and pathological responses [Review].

  10. The single nucleotide polymorphism rs78202224 (G>T) was significantly associated with increased risk of breast cancer.

  11. results thus contribute to the knowledge of the regulatory mechanism of HSF1 in down-regulating ArgBP2, providing new insight into the HSF1&MORC2-PRC2-ArgBP2 signaling pathway and a better understanding of their functions in gastric cancer cells.

  12. These findings indicate that activation of HSF1 at Ser326 residue and transcription of HSP27 is related to the maintenance of gynecological CSCs/CICs.

  13. Results show that HSF1 is a key transcription factor for inducing the expression of DNAJB8 and SOX2 and that cellular stress induces cancer stem-like cells through the expression of DNAJB8 by activation of HSF1 .

  14. The mRNA expression levels of heat shock transcription factor 1 (HSF1) in estrogen receptor (ER)-positive breast cancer are associated with both shorter relapse-free and overall survival.

  15. Our study provides evidence that HSF1 functions as a novel oncogene in pancreatic tumors and is implicated as a target for the diagnosis and treatment of pancreatic cancer.

  16. In normal ovarian tissues, HSF1 was barely detected, whereas, high expression of HSF1 was found in malignant epithelial ovarian cancer (EOC) tissues, including serous, mucinous, endometrioid, and clear cell EOC tissues.

  17. Our findings show that miR-487a, mediated by heat shock factor 1, promotes proliferation and metastasis of Hepatocellular carcinoma (HCC) by PIK3R1 and SPRED2 binding, respectively. Our study provides a rationale for developing miR-487a as a potential prognostic marker or a potential therapeutic target against HCC.

  18. HSF1 activity is decreased in fibrotic hearts. HSF1 inhibits phosphorylation and nuclear distribution of Smad3 via direct binding to Smad3. Active Smad3 blocks the anti-fibrotic effect of HSF1.

  19. Results suggest for targeting heat shock factor 1 (HSF1)activation in combination with bortezomib to enhance multiple myeloma treatment efficacy.

  20. MD simulation of high-resolution X-ray structures reveals post-translational modification dependent conformational changes in HSF-DNA interaction.

Cow (Bovine) Heat Shock Factor Protein 1 (HSF1) interaction partners

  1. The association between the HSF 1 expression and antioxidative activity through correlation analysis was found to be non-significant, though enzymatic activity appeared to behave in a similar fashion in both breeds at 5% level of significance, thus ruling out the role of HSF1 expression level on the activity of enzymes involved in oxidative stress in vitro in zebu and crossbred cattle.

  2. As the 4693-T mutation caused the disruption of microRNA target binding (resulting in the relief of the transcriptional repression), the HSF1 gene is useful in dairy cattle thermal tolerant breeding.

Chlamydomonas reinhardtii (C. reinhardtii) Heat Shock Factor Protein 1 (HSF1) interaction partners

  1. HSF1 is a key trans-acting factor for counteracting transgene promoter silencing in Chlamydomonas.

  2. Data show that activated HSF1 and CRR1 transcription factors mediate the acetylation of histones H3/4, nucleosome eviction, remodeling of the H3K4 mono- and dimethylation marks, and transcription initiation/elongation.

  3. data suggest that HSF1 is a key regulator of the stress response in Chlamydomonas

Rabbit Heat Shock Factor Protein 1 (HSF1) interaction partners

  1. Data suggest that myocardial HSF1 and HSP70 (70 kDa heat-shock protein) can be up-regulated by dietary factors (here, antioxidant taurine as a dietary supplement administered to counteract effects of atherogenic diet).

Pig (Porcine) Heat Shock Factor Protein 1 (HSF1) interaction partners

  1. The results indicate that Heat shock protein 70 (Hsp70) mediates distinct stress-related functions in different tissues during transportation. Heat shock factor-1 (HSF-1) levels were reduced at 1 and 4 h only in the hearts of transported pigs.

Zebrafish Heat Shock Factor Protein 1 (HSF1) interaction partners

  1. The transcriptional up-regulation of unc45b, hsp90aa1.1 and smyd1b is specific to zebrafish mutants with myosin folding defects, and is not triggered in other zebrafish myopathy models

  2. data suggest that HSF1 is involved in regulating constitutive lens specific expression of hsp70 in the embryonic zebrafish

HSF1 Antigen Profile

Protein Summary

The product of this gene is a heat-shock transcription factor. Transcription of heat-shock genes is rapidly induced after temperature stress. Hsp90, by itself and/or associated with multichaperone complexes, is a major repressor of this gene.

Gene names and symbols associated with HSF1

  • heat shock factor (hsf1) antibody
  • Heat Shock Factor (hsf-1) antibody
  • heat shock factor 1 (Hsf1) antibody
  • heat shock transcription factor 1 (HSF1) antibody
  • heat shock transcription factor 1 (Hsf1) antibody
  • heat shock transcription factor 1 (hsf1) antibody
  • heat shock transcription factor 1 S homeolog (hsf1.S) antibody
  • AA960185 antibody
  • HSF antibody
  • HSF1 antibody
  • hsf1a antibody
  • hsf1b antibody
  • HSF1c antibody
  • hstf1 antibody
  • xhsf1 antibody
  • zHSF1a antibody
  • zHSF1b antibody

Protein level used designations for HSF1

heat shock factor protein , HSTF , heat shock transcription factor , Heat Shock Factor family member (hsf-1) , HSF 1 , HSTF 1 , heat shock factor protein 1 , heat shock transcription factor 1

GENE ID SPECIES
399268 Xenopus laevis
173078 Caenorhabditis elegans
15499 Mus musculus
3297 Homo sapiens
506235 Bos taurus
79245 Rattus norvegicus
5720002 Chlamydomonas reinhardtii
100350887 Oryctolagus cuniculus
101787582 Cavia porcellus
475124 Canis lupus familiaris
100511321 Sus scrofa
420362 Gallus gallus
58123 Danio rerio
779172 Xenopus laevis
Selected quality suppliers for anti-HSF1 (HSF1) Antibodies
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