Hemoglobin, alpha 2 Proteins (HBa2)

The human alpha globin gene cluster located on chromosome 16 spans about 30 kb and includes seven loci: 5'- zeta - pseudozeta - mu - pseudoalpha-1 - alpha-2 - alpha-1 - theta - 3'. Additionally we are shipping HBa2 Antibodies (18) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
HBa2 3040 P69905
Rat HBa2 HBa2 360504 P01946
HBa2    
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Top HBa2 Proteins at antibodies-online.com

Showing 6 out of 8 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Wheat germ Human GST tag 10 μg Log in to see 11 to 12 Days
$325.44
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Escherichia coli (E. coli) Human His tag 100 μg Log in to see 15 to 19 Days
$400.00
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Yeast Xenopus laevis His tag   1 mg Log in to see 60 to 71 Days
$2,302.67
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Yeast Aythya fuligula His tag   1 mg Log in to see 60 to 71 Days
$2,302.67
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Yeast Triturus His tag   1 mg Log in to see 60 to 71 Days
$2,302.67
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Yeast Human Un-conjugated   100 μg Log in to see 11 to 16 Days
$341.12
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HBa2 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , ,
,
Aythya fuligula

More Proteins for Hemoglobin, alpha 2 (HBa2) Interaction Partners

Human Hemoglobin, alpha 2 (HBa2) interaction partners

  1. Chinese family with delta-thalassemia (delta-thal) was found, in which the daughter is homozygous for delta-thal (HBD: c.-127T>C) with complete deficiency of Hb A2 and the mother is a heterozygote with low level of Hb A2

  2. father carried the rare nondeletional Hb Adana mutation [alpha59(E8)Gly-->Asp, HBA2: c.179G>A] on the alpha2-globin gene

  3. Changes in HbA2 and HbF in alpha thalassemia carriers with KLF1 mutation.

  4. A single genetic origin is responsible for the spread and high prevalence of the alpha(0)-thalassemia (SEA deletion) in Southeast Asian populations and allow the monitoring of possible maternal contamination at prenatal diagnosis of this important genetic disorder.

  5. In this study, a novel promoter mutation of -72 (T-->A) within the conserved CCAAT box of beta-globin gene has been identified in heterozygous state. The proband and his two relatives carrying the same mutation showed almost normal mean corpuscular volume (MCV) and mean corpuscular hemoglobin (MCH) level and slightly elevated HbA2.

  6. In this paper, the experimental results of resonance Raman, terahertz time-domain, and 1H nuclear magnetic resonance spectroscopy for the Hb M are described in detail. The heterogeneity of alpha subunits, which has been observed previously, is reconfirmed, and its implications for the dynamical structure of the alpha2beta2 tetramer and the regulation of O2 affinity are discussed.

  7. This study presents comparison of two neutron structures of hemoglobins, human deoxyhemoglobin (T state) and equine cyanomethemoglobin (R state) and offers a direct observation of histidine residues that are likely to contribute to the Bohr effect.

  8. Carriers of Hb Nanning are asymptomatic and could be missed by screening based on MCV and MCH cutoffs of <80.0 fL and <27.0 pg, respectively. Both carriers of the mutation in the study have MCV and MCH values that are 2 standard deviations (SDs) below normal, as would be predicted for an alpha+-thal.

  9. Data indicate that binding of hemoblobin (Hb) to glycoprotein1balpha (GP1balpha) induced platelet activation plays a crucial role in thrombus formation on immobilized von Willebrand factor (VWF) or type I collagen under shear stresses.

  10. Hb Adana mutation was preferentially present in the alpha2-globin genes in Malays compared to the other ethnicities in Malaysia.

  11. 14 alpha thalassemia mutations were found among 95 Turkish patients. Most were gene deletions. A new alpha 2 initiation codon mutation was discovered.

  12. The hematological and molecular data of 35 patients with Hb H disease and the genotypes of alpha-gene mutations of 78 screened individuals were used to identify the genotypes of Hb H disease and genotype-phenotype correlations. the most common genotypes were -alpha3.7/--20.5, -alpha3.7/--26.5, and -alpha3.7/--17.5. Other small deletions, non-deleltional mutations, and combinations thereof in trans were associated with...

  13. Seven novel nondeletional alpha-thalassemia mutations localized on the alpha2-globin gene in the heterozygous state were identified

  14. Gene frequency for HBA2:c.301-24delGinsCTCGGCCC carriers among the Chinese population in Guangxi.

  15. Hemoglobin Constant Spring mutation in Southeast Asians with thalassemia.

  16. We report herein for the first time the description of HbA2' in the Tunisian population.

  17. In maturing RBC progenitors AHSP bind to free alpha-globin chains to increase the HbA production. (Review)

  18. Two mutations detected the -a(3,7) single gene deletion found in 75% of cases and the nongene deletion a2 IVS1 [-5nt] in the remaining samples

  19. Copy number variations in alpha-globin 2 gene is associated with increased levels of HbF with beta thalassemia.

  20. Described is a previously unreported HBA2 gene variant predicted to lead to an in-frame deletion of codons 13 and 14 of the a-globin chain.

Cow (Bovine) Hemoglobin, alpha 2 (HBa2) interaction partners

  1. both Ciprofloxacin and enrofloxacin could lead to the conformational and microenvironmental changes of bovine hemoglobin.

  2. Determination of a representative formal redox potentials of the Fe(II)/Fe(III) redox couple cyanhaemoglobin/cyanmethaemoglobin and the myoglobin/metmyoglobin , at pH=7 and related to the state in solution, was the objective of this work.

  3. Data indicate that on incubating hemoglobin with glyoxal for 0-20 days, advanced glycation end products (AGEs) were detected on day 20.

  4. Ultraviolet irradiation results in fluorescence enhancement of bovine hemoblobin in a dose-dependent manner.

  5. These results indicate that IsdX2 has all the features required to acquire heme from the host and transport heme to the bacterial cell wall.

  6. Residues 33-61a of hemoglobin alpha-chain from cattle tick gut exhibit nonconventional conformation for an antimicrobial peptide, bound to sodium dodecyl sulfate micelles. The peptide is able to disrupt the bacterial membrane of Micrococcus luteus A270.

  7. The acid-induced denaturation of Hb follows a highly symmetric mechanism.

Horse (Equine) Hemoglobin, alpha 2 (HBa2) interaction partners

  1. This study presents comparison of two neutron structures of hemoglobins, human deoxyhemoglobin (T state) and equine cyanomethemoglobin (R state) and offers a direct observation of histidine residues that are likely to contribute to the Bohr effect.

  2. cyanomethemoglobin is in the R state and preliminary room-temperature electron and neutron scattering density maps clearly show the protonation states of potential Bohr groups.

HBa2 Protein Profile

Protein Summary

The human alpha globin gene cluster located on chromosome 16 spans about 30 kb and includes seven loci: 5'- zeta - pseudozeta - mu - pseudoalpha-1 - alpha-2 - alpha-1 - theta - 3'. The alpha-2 (HBA2) and alpha-1 (HBA1) coding sequences are identical. These genes differ slightly over the 5' untranslated regions and the introns, but they differ significantly over the 3' untranslated regions. Two alpha chains plus two beta chains constitute HbA, which in normal adult life comprises about 97% of the total hemoglobin\; alpha chains combine with delta chains to constitute HbA-2, which with HbF (fetal hemoglobin) makes up the remaining 3% of adult hemoglobin. Alpha thalassemias result from deletions of each of the alpha genes as well as deletions of both HBA2 and HBA1\; some nondeletion alpha thalassemias have also been reported.

Gene names and symbols associated with Hemoglobin, alpha 2 Proteins (HBa2)

  • hemoglobin subunit alpha 2 (HBA2)
  • hemoglobin subunit alpha 2 L homeolog (hba2.L)
  • hemoglobin subunit mu (HBM)
  • hemoglobin, alpha 2 (HBA)
  • hemoglobin, alpha 2 (HBA2)
  • hemoglobin, alpha 2 (Hba2)
  • alpha globin protein
  • HBA2 protein
  • hba5 protein
  • HBH protein

Protein level used designations for Hemoglobin, alpha 2 Proteins (HBa2)

alpha globin , alpha-2 globin , alpha-globin , hemoglobin alpha chain , hemoglobin subunit alpha , alpha T5 (aa 1-142) , alpha-5-globin , alpha-T5 , hemoglobin alpha-5 chain , hemoglobin subunit alpha-5 , adult alpha D globin , hemoglobin alpha-D chain , hemoglobin subunit alpha-D , hemoglobin, alpha 2 , globin, alpha 2 , hemoglobin, subunit alpha 2 , 2-alpha globin , 2-alpha-1 globin , hemoglobin alpha 2 chain

GENE ID SPECIES
3040 Homo sapiens
379435 Xenopus laevis
416651 Gallus gallus
512439 Bos taurus
100036558 Equus caballus
360504 Rattus norvegicus
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