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The human alpha globin gene cluster located on chromosome 16 spans about 30 kb and includes seven loci: 5'- zeta - pseudozeta - mu - pseudoalpha-1 - alpha-2 - alpha-1 - theta - 3'. Additionally we are shipping HBa2 Antibodies (16) and many more products for this protein.
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Changes in HbA2 and HbF in alpha thalassemia carriers with KLF1 (show KLF1 Proteins) mutation.
A single genetic origin is responsible for the spread and high prevalence of the alpha(0)-thalassemia (SEA (show Slc25a1 Proteins) deletion) in Southeast Asian populations and allow the monitoring of possible maternal contamination at prenatal diagnosis of this important genetic disorder.
In this study, a novel promoter mutation of -72 (T-->A) within the conserved CCAAT box of beta-globin (show HBB Proteins) gene has been identified in heterozygous state. The proband and his two relatives carrying the same mutation showed almost normal mean corpuscular volume (MCV) and mean corpuscular hemoglobin (show HBB Proteins) (MCH (show PMCH Proteins)) level and slightly elevated HbA2.
Carriers of Hb Nanning are asymptomatic and could be missed by screening based on MCV and MCH (show PMCH Proteins) cutoffs of <80.0 fL and <27.0 pg, respectively. Both carriers of the mutation in the study have MCV and MCH (show PMCH Proteins) values that are 2 standard deviations (SDs (show SDS Proteins)) below normal, as would be predicted for an alpha+-thal.
Data indicate that binding of hemoblobin (Hb) to glycoprotein1balpha (GP1balpha) induced platelet activation plays a crucial role in thrombus formation on immobilized von Willebrand factor (VWF (show VWF Proteins)) or type I collagen under shear stresses.
Hb Adana mutation was preferentially present in the alpha2-globin genes in Malays compared to the other ethnicities in Malaysia.
Seven novel nondeletional alpha-thalassemia mutations localized on the alpha2-globin gene in the heterozygous state were identified
Gene frequency for HBA2:c.301-24delGinsCTCGGCCC carriers among the Chinese population in Guangxi.
Hemoglobin Constant Spring mutation in Southeast Asians with thalassemia.
We report herein for the first time the description of HbA2' in the Tunisian population.
both Ciprofloxacin and enrofloxacin could lead to the conformational and microenvironmental changes of bovine hemoglobin.
Determination of a representative formal redox potentials of the Fe(II)/Fe(III) redox couple cyanhaemoglobin/cyanmethaemoglobin and the myoglobin (show MB Proteins)/metmyoglobin , at pH=7 and related to the state in solution, was the objective of this work.
Data indicate that on incubating hemoglobin with glyoxal for 0-20 days, advanced glycation end products (AGEs) were detected on day 20.
Residues 33-61a of hemoglobin alpha-chain (show HBA-A1 Proteins) from cattle tick gut (show GUSB Proteins) exhibit nonconventional conformation for an antimicrobial peptide (show CAMP Proteins), bound to sodium dodecyl sulfate micelles. The peptide is able to disrupt the bacterial membrane of Micrococcus luteus A270.
The human alpha globin gene cluster located on chromosome 16 spans about 30 kb and includes seven loci: 5'- zeta - pseudozeta - mu - pseudoalpha-1 - alpha-2 - alpha-1 - theta - 3'. The alpha-2 (HBA2) and alpha-1 (HBA1) coding sequences are identical. These genes differ slightly over the 5' untranslated regions and the introns, but they differ significantly over the 3' untranslated regions. Two alpha chains plus two beta chains constitute HbA, which in normal adult life comprises about 97% of the total hemoglobin\; alpha chains combine with delta chains to constitute HbA-2, which with HbF (fetal hemoglobin) makes up the remaining 3% of adult hemoglobin. Alpha thalassemias result from deletions of each of the alpha genes as well as deletions of both HBA2 and HBA1\; some nondeletion alpha thalassemias have also been reported.
, alpha-2 globin
, hemoglobin alpha chain
, hemoglobin subunit alpha
, alpha T5 (aa 1-142)
, hemoglobin alpha-5 chain
, hemoglobin subunit alpha-5
, adult alpha D globin
, hemoglobin alpha-D chain
, hemoglobin subunit alpha-D
, hemoglobin, alpha 2
, globin, alpha 2
, hemoglobin, subunit alpha 2
, 2-alpha globin
, 2-alpha-1 globin
, hemoglobin alpha 2 chain