anti-Hepatitis A Virus Cellular Receptor 1 (HAVCR1) Antibodies

The protein encoded by HAVCR1 is a membrane receptor for both human hepatitis A virus (HHAV) and TIMD4. Additionally we are shipping HAVCR1 Kits (114) and HAVCR1 Proteins (45) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
HAVCR1 26762 Q96D42
HAVCR1 286934 O54947
HAVCR1 171283 Q5QNS5
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Top anti-HAVCR1 Antibodies at

Showing 10 out of 276 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Human Rabbit Un-conjugated ICC, IHC (p), WB 100 μg Log in to see 4 to 6 Days
Human Rabbit Un-conjugated WB WB Suggested Anti-HAVCR1 Antibody Titration: 0.2-1 ug/ml ELISA Titer: 1:12500 Positive Control: Human Muscle 100 μL Log in to see 2 to 3 Days
Human Rabbit Un-conjugated WB 100 μg Log in to see 4 to 6 Days
Rat Rabbit Un-conjugated IHC (fro), IHC (p), WB Anti-TIM 1 antibody, Western blotting Lane 1: SMMC Cell Lysate Lane 2: HELA Cell Lysate Lane 3: PANC Cell Lysate Lane 4: MM231 Cell Lysate Lane 5: MM453 Cell Lysate Anti-TIM 1 antibody, IHC(P) IHC(P): Rat Testis Tissue 100 μg Log in to see 4 to 6 Days
Human Mouse Un-conjugated CyTOF, FACS, IHC, WB Detection of Human TIM-1/KIM-1/HAVCR by Western Blot. Western blot shows lysates of human CD4+ cells treated (+) with 5 ug/mL of Hamster Anti-Mouse CD3 epsilon Monoclonal Antibody. This experiment was conducted under reducing conditions. Detection of TIM-1/KIM-1/HAVCR in Th2-stimulated Human PBMCs by Flow Cytometry. (A) Unstimulated and (B) Th2-stimulated human PBMCs were stained with Mouse Anti-Human TIM-1/KIM-1/HAVCR Monoclonal Antibody. 100 μg Log in to see 8 to 9 Days
Human Rabbit Un-conjugated WB HAVCR1 Antibody (N-term) (ABIN657951) western blot analysis in K562 cell line lysates (35 µg/lane). This demonstrates the HAVCR1 antibody detected the HAVCR1 protein (arrow). 400 μL Log in to see 10 to 11 Days
Human Goat Un-conjugated ELISA, WB   100 μg Log in to see 6 to 7 Days
Human Rabbit Un-conjugated IHC, IHC (p), WB Human Testis (formalin-fixed, paraffin-embedded) stained with HAVCR1 antibody ABIN292372 at 2.5-5 ug/ml followed by biotinylated goat anti-rabbit IgG secondary antibody ABIN481713, alkaline phosphatase-streptavidin and chromogen. Anti-TIM-1 antibody IHC of human testis. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml. 50 μg Log in to see 11 to 14 Days
Human Rabbit Un-conjugated ELISA, ICC, IF, IHC, IHC (p), WB   0.1 mg Log in to see 8 to 11 Days
Human Rabbit Un-conjugated WB 0.1 mg Log in to see 6 to 8 Days

Top referenced anti-HAVCR1 Antibodies

  1. Human Polyclonal HAVCR1 Primary Antibody for ELISA, ICC - ABIN4359752 : Lim, Chan, Lai, Tang, Chow, Lam, Leung: Distinct role of matrix metalloproteinase-3 in kidney injury molecule-1 shedding by kidney proximal tubular epithelial cells. in The international journal of biochemistry & cell biology 2012 (PubMed)
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  2. Human Monoclonal HAVCR1 Primary Antibody for CyTOF, FACS - ABIN4899579 : Ivie, Fennessey, Sheng, Rubin, McClain: Gene-trap mutagenesis identifies mammalian genes contributing to intoxication by Clostridium perfringens ε-toxin. in PLoS ONE 2011 (PubMed)
    Show all 4 Pubmed References

  3. Human Polyclonal HAVCR1 Primary Antibody for WB - ABIN4359750 : Xu, Cheng, Wen, Oh, Mou, Shi, Xu, Li: Inverse association between T-cell immunoglobulin and mucin domain-1 and T-bet in a mouse model of allergic rhinitis. in The Laryngoscope 2007 (PubMed)
    Show all 2 Pubmed References

  4. Human Polyclonal HAVCR1 Primary Antibody for IHC (p), WB - ABIN541533 : Ichimura, Bonventre, Bailly, Wei, Hession, Cate, Sanicola: Kidney injury molecule-1 (KIM-1), a putative epithelial cell adhesion molecule containing a novel immunoglobulin domain, is up-regulated in renal cells after injury. in The Journal of biological chemistry 1998 (PubMed)
    Show all 3 Pubmed References

  5. Human Polyclonal HAVCR1 Primary Antibody for WB - ABIN541534 : Feigelstock, Thompson, Mattoo, Zhang, Kaplan: The human homolog of HAVcr-1 codes for a hepatitis A virus cellular receptor. in Journal of virology 1998 (PubMed)
    Show all 3 Pubmed References

  6. Human Polyclonal HAVCR1 Primary Antibody for WB - ABIN6670387 : Adeoye, Asenuga, Oyagbemi, Omobowale, Adedapo: The Protective Effect of the Ethanol Leaf Extract of Andrographis Paniculata on Cisplatin-Induced Acute Kidney Injury in Rats Through nrf2/KIM-1 Signalling Pathway. in Drug research 2018 (PubMed)

  7. Mouse (Murine) Polyclonal HAVCR1 Primary Antibody for ICC, IHC - ABIN1077715 : Schindler, Bondeva, Schindler, Claus, Franke, Wolf: Preconditioned suppression of prolyl-hydroxylases attenuates renal injury but increases mortality in septic murine models. in Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 2016 (PubMed)

More Antibodies against HAVCR1 Interaction Partners

Human Hepatitis A Virus Cellular Receptor 1 (HAVCR1) interaction partners

  1. We used the CRISPR/Cas9 system to knock-in reporter transgenes at the kidney injury molecule-1 (KIM-1) locus and isolated proximal tubule cell (HK-2) clones. PCR verified targeted knock-in of the luciferase and eGFP reporter at the KIM-1 locus. HK-2-KIM-1 reporter cells responded to various stimuli including hypoxia, cisplatin, and high glucose, indicative of upregulation of KIM-1 expression.

  2. The urinary KIM-1 increases rapidly upon the tubular injury, and its levels are associated with the degree of tubular injury, interstitial fibrosis, and inflammation in the injured kidney.

  3. In conclusion, these findings demonstrate that TIM-1 promotes Japanese encephalitis virus infection as an entry cofactor, and the polymorphism of TIM-1 is associated with Japanese encephalitis virus susceptibility to host cells.

  4. neither the inflammatory biomarker calprotectin, nor the tubular biomarkers NGAL and KIM-1, provide robust prognostic information on the loss of renal function in a heterogeneous CKD population. All of them, however, are candidate prognostic biomarkers in primarily inflammatory renal diseases.

  5. High KIM1 expression is associated with Clear Cell Renal Cell Carcinoma.

  6. Human oligodendrocytes undergo apoptosis when exposed to Sema4A and take up H-ferritin for meeting iron requirements and that these functions are mediated via the Tim-1 receptor. H-ferritin can block Sema4A-mediated cytotoxicity. Sema4A is detectable in the CSF of multiple sclerosis patients and HIV-seropositive persons and can induce oligodendrocyte cell death.

  7. Elevated plasma NT-proBNP and KIM-1 in patients with stage 5 chronic kidney disease (CKD5) undergoing maintenance hemodialysis (HD) and HF (+) (heart failure)CKD5-HD patients suggest that natriuretic peptides and KIM-1 may contribute to the pathogenesis of HF in CKD5-HD patients.

  8. These findings suggest that the TIMD4-HAVCR1 variants may be the genetic risk factors for coronary heart disease and ischemic strok

  9. These studies provide evidence that, in the absence of a functional alpha-dystroglycan, TIM-1 mediates the entry of Lassa virus pseudoviral particles through interactions of virions with the IgV PtdSer-binding pocket of TIM-1.

  10. total flavone of Desmodium styracifolium inhibited HK-2 cell apoptosis and autophagy by regulating KIM-1 via p38/MAPK pathway.

  11. Polymorphism +4259A>C in exon 3 of the TIM-3 gene is associated with susceptibility to multiple sclerosis but polymorphism -1637C>T in the promoter region of TIM-1 is not.

  12. High KIM1 expression is associated with decreased proximal tubular epithelial cell function.

  13. findings show that TIM1 is not an essential cellular receptor for hepatitis A virus entry into cultured cells

  14. Urinary excretion of KIM-1 correlates with blood lead levels better than other traditional renal injury biomarkers, including N-acetyl-beta-(D)-glucosaminidase, alpha1-microglobulin, and beta2-microglobulin.

  15. promising results were obtained for circulating KIM-1 prediction of renal outcomes in type 1 diabetes--{REVIEW}

  16. data show that in addition to the phospholipid-binding function of HAVCR1, the enhancement of HCV infection involves other determinants in the IgV domain of HAVCR1. These findings expand the repertoire of molecules that HCV uses for cell entry, adding to the already complex mechanism of HCV infection and pathogenesis.

  17. Review/Meta-analysis: suggest that TIM-1-416G[C single nucleotide polymorphism is associated with the risk of asthma for the Asian ethnicity in the codominant (G/G vs. G/C) and dominant (G/G vs. G/C + C/C) genetic models.

  18. Urinary NGAL is a good predictor of mortality in established pediatric acute kidney injury (AKI) of heterogeneous etiology and outperforms calprotectin and KIM-1. Urinary calprotectin and KIM-1 predict renal replacement therapy requirement in pediatric AKI.

  19. A panel consisting of IGFBP1, KIM1, GCLC and GSTM1 genes could be used in combination for early screening of CKDu, whereas these genes in addition with FN1, IGFBP3 and KLK1 could be used to monitor progression of CKDu. The regulation of these genes has to be studied on larger populations to validate their efficiency for further clinical use.

  20. Quantification of TIM-3 and KIM-1 mRNA expressions, along with KIM-1 protein measurements in urine and blood could be employed as promising tools for noninvasive diagnosis of allograft dysfunction.

Chimpanzee Hepatitis A Virus Cellular Receptor 1 (HAVCR1) interaction partners

  1. Data suggest that T-cell immunoglobulin domain and mucin domain containing protein 1 (TIM1) to be under positive natural selection in primates.

Rhesus Monkey Hepatitis A Virus Cellular Receptor 1 (HAVCR1) interaction partners

  1. Data suggest that T-cell immunoglobulin domain and mucin domain containing protein 1 (TIM1) to be under positive natural selection in primates.

Mouse (Murine) Hepatitis A Virus Cellular Receptor 1 (HAVCR1) interaction partners

  1. Our findings suggest a role for UMOD-dependent inhibition of KIM-1 expression and its apoptotic cell scavenging responses during chronic obstruction-associated tubular injury

  2. findings show that TIM1 is not required for hepatitis A virus (HAV) replication and pathogenesis in permissive strains of mice, although it may facilitate early stages of infection by binding phosphatidylserine on the quasi-enveloped HAV surface

  3. the interaction of TIM4TIM1 was found to promote Th2cell proliferation through enhancing SIRT1 expression in mice with nasal allergic rhinitis.

  4. findings provide evidence for the role of Tim-1 in the induction of a cytokine storm phenomenon and the pathogenesis of Ebola virus disease

  5. Cisplatin enhances kidney injury molecule-1 (Kim-1) gene expression in kidney S3 cells.

  6. By preventing ERK1/2 phosphorylation following renal injury, STAT3 phosphorylation is decreased, leading to less phosphorylated STAT3 within the nucleus, and subsequently less KIM-1 mRNA increases post injury

  7. Study used a previously described highly mobile membrane mimetic membrane in combination with a conventional lipid bilayer model to generate a membrane-bound configuration of Tim1 in silico, identified two possible states for a membrane-bound form of Tim1.

  8. Our data reveal a previously unknown role for Galpha12 in regulating efferocytosis and that renal tubular epithelial cells require KIM-1 to mediate this process.

  9. Urinary L-FABP, NGAL, Kim-1 and albumin levels increased during the acute phase of kidney injury and were significantly correlated with the degree of tubulointerstitial fibrosis during the chronic phase. These markers could detect higher risk of progression to CKD.

  10. Blockade of Tim-1 changes Th1/Th2 balance and reduces circulating regulatory T cells to enhance atherosclerosis in LDL receptor knockout mice.

  11. Our results suggest that KIM-1 is an endogenous protective mechanism against renal ischemia-reperfusion injury

  12. data suggest that TIM-1 signaling plays a direct role in Breg maintenance and induction both under physiological conditions (in response to ACs) and in response to therapy through TIM-1 ligation

  13. Deletion of the mucin domain impaired KIM-1-mediated phagocytic function, resulting in increased proinflammatory cytokine production, decreased antiinflammatory growth factor secretion by proximal epithelial cells, and an increase in tissue macrophages.

  14. Tim-1 is critical for maintaining self-tolerance by regulating IL-10 production in Bregs

  15. blood biomarker that specifically reflects acute and chronic kidney injury

  16. Tim-1 expression was lower in a herpes simplex virus-induced Behcet's disease (BD) mouse model compared to that in asymptomatic BD normal (BDN) mice.

  17. Tim-1-Fc protects cardiac grafts from chronic rejection by suppressing CD4 Th17 development and functionality.

  18. KIM-1 shedding is accelerated by worsening renal cellular injury, and excess soluble KIM-1 competitively inhibits efferocytosis.

  19. Endogenous Tim-1 promotes severe systemic autoimmunity and renal disease MRL-Fas(lpr) mice.

  20. a major P-selectin ligand with a role in T cell trafficking during inflammatory responses and the induction of autoimmune disease

HAVCR1 Antigen Profile

Protein Summary

The protein encoded by this gene is a membrane receptor for both human hepatitis A virus (HHAV) and TIMD4. The encoded protein may be involved in the moderation of asthma and allergic diseases. The reference genome represents an allele that retains a MTTVP amino acid segment that confers protection against atopy in HHAV seropositive individuals. Three transcript variants encoding the same protein have been found for this gene.

Gene names and symbols associated with HAVCR1

  • hepatitis A virus cellular receptor 1 (HAVCR1) antibody
  • hepatitis A virus cellular receptor 1 (Havcr1) antibody
  • hepatitis A virus cellular receptor 1 homolog (LOC100226241) antibody
  • AI503787 antibody
  • HAVCR antibody
  • HAVCR-1 antibody
  • HAVCR1 antibody
  • KIM-1 antibody
  • Kim1 antibody
  • LOC100226241 antibody
  • TIM antibody
  • TIM-1 antibody
  • Tim1 antibody
  • TIMD-1 antibody
  • Timd1 antibody

Protein level used designations for HAVCR1

T cell immunoglobin domain and mucin domain protein 1 , T-cell membrane protein 1 , kidney injury molecule 1 , HAVcr-1 , TIMD-1 , hepatitis A virus cellular receptor 1 homolog , t cell immunoglobulin and mucin domain-containing protein 1 , hepatitis A virus cellular receptor 1 , T-cell immunoglobulin and mucin domain containing 1 , t cell membrane protein 1 , T-cell immunoglobulin and mucin domain-containing protein 1

26762 Homo sapiens
286934 Rattus norvegicus
416249 Gallus gallus
462218 Pan troglodytes
612069 Canis lupus familiaris
614846 Bos taurus
715333 Macaca mulatta
100226241 Taeniopygia guttata
100303721 Sus scrofa
171283 Mus musculus
102141332 Macaca fascicularis
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