Rules of RNA specificity of hnRNP A1 revealed by global and quantitative analysis of its affinity distribution have been described.
study showed that UVB induces alternative splicing of hdm2 by increasing the expression and the binding of hnRNP A1 to hdm2 full-length mRNA
The authors show by NMR spectroscopy that both RNA recognition motifs of hnRNP A1 can bind simultaneously to a single bipartite motif of the human intronic splicing silencer ISS-N1, which controls survival of motor neuron exon 7 splicing.
current knowledge of the involvement of hnRNPA1 in cancer, including its roles in regulating cell proliferation, invasiveness, metabolism, adaptation to stress and immortalization.
Case Report: inflammatory myofibroblastic tumor (IMT) of the urinary bladder with a novel HNRNPA1-ALK fusion.
EGF signaling upregulates an E3 ubiquitin (Ub) ligase adaptor, SPRY domain-containing SOCS box protein 1 (SPSB1), which recruits Elongin B/C-Cullin complexes to conjugate lysine 29-linked poly Ubiquitin chains onto hnRNP A1.
hnRNP A1 directly binds to the 5' untranslated region of the RON (show MST1R ELISA Kits) mRNA and activates its translation through G-quadruplex RNA secondary structures
We demonstrate that the wild-type sequence harbors an hnRNP A1 and hnRNP A2/B1 (show HNRNPA2B1 ELISA Kits)-binding exonic splicing silencer (ESS) overlapping the 5'splice site (5'ss) that prevents pseudoexon inclusion.we demonstrate that splice switching oligonucleotide (SSO) mediated blocking of the pseudoexon 3'ss and 5'ss effectively restores normal GLA splicing
The hnRNP A1 binding map can be used to identify potential targets for splice-switching oligonucleotides-based therapy.
Biophysical titrations reveal that the 5'-AUAGC-3' bulge undergoes a conformational change to assemble a functional hnRNP A1-human enterovirus 71 RNA complex.
Study demonstrated that hnRNPA1 plays a critical and irreplaceable role in embryonic muscle development by regulating the expression and alternative splicing of muscle-related genes.
hnRNPA1 is a critical regulator of vascular smooth muscle cell function and behavior in the context of neointima hyperplasia via miR (show MLXIP ELISA Kits)-124/IQGAP1 (show IQGAP1 ELISA Kits) regulatory axis.
PRMT5 regulates internal ribosome entry site-dependent translation via methylation of hnRNP A1.
Resveratrol causes a shift from the mesenchymal-specific forms of these factors to the respective epithelial forms and increases the expression of the RNA-binding proteins KHSRP (show KHSRP ELISA Kits) and hnRNPA1.
this study identified hnRNPA1, an RNA-binding protein and auxiliary splicing factor, as a substrate of TRAF6 (show TRAF6 ELISA Kits); TRAF6 (show TRAF6 ELISA Kits) ubiquitination of hnRNPA1 regulated alternative splicing of Arhgap1, which resulted in activation of the GTP-binding Rho family protein Cdc42 (show CDC42 ELISA Kits) and accounted for hematopoietic defects in TRAF6 (show TRAF6 ELISA Kits)-expressing hematopoietic stem/ progenitor cells
hnRNP A1 improves intestinal injury in anti-CD3 (show CD3E ELISA Kits) antibody-induced enteritis mice through the upregulation of TFF2 (show TFF2 ELISA Kits), which regulates apoptosis and enhances epithelial restoration
Relevant to biological processes anticipated for hnRNP A1 and HuR (show ELAVL1 ELISA Kits).
This study provides evidence that PCBP2 and hnRNP A1 bind to the 5' and 3' ends of the murine norovirus 1 viral RNA and contribute to RNA circularization, playing a role in the virus life cycle.
Heteronuclear ribonucleoprotein (show RBP31 ELISA Kits) A1 interacts with an element that overlaps the 5' splice site of Mag (show MAG ELISA Kits) exon 12.
MMP-3 (show MMP3 ELISA Kits)-triggered Rac1 splicing regulation is modulated by hnRNP A1
the swine HNRPA1 gene was moderately expressed in fat, spleen and kidney, weakly expressed in muscle and lung, and hardly expressed in small intestine, large intestine and liver.
This gene belongs to the A/B subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are RNA binding proteins and they complex with heterogeneous nuclear RNA (hnRNA). These proteins are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus, some seem to shuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. The protein encoded by this gene has two repeats of quasi-RRM domains that bind to RNAs. It is one of the most abundant core proteins of hnRNP complexes and it is localized to the nucleoplasm. This protein, along with other hnRNP proteins, is exported from the nucleus, probably bound to mRNA, and is immediately re-imported. Its M9 domain acts as both a nuclear localization and nuclear export signal. The encoded protein is involved in the packaging of pre-mRNA into hnRNP particles, transport of poly A+ mRNA from the nucleus to the cytoplasm, and may modulate splice site selection. It is also thought have a primary role in the formation of specific myometrial protein species in parturition. Multiple alternatively spliced transcript variants have been found for this gene but only two transcripts are fully described. These variants have multiple alternative transcription initiation sites and multiple polyA sites.
heterogeneous nuclear ribonucleoprotein A1 , hnRNP core protein A1 , helix-destabilizing protein , single-strand-binding protein , hormonally upregulated Neu-associated kinase , Heterogeneous nuclear ribonucleoprotein A1 , heterogeneous ribonuclear particle protein , hnRNP A1 , Putative heterogeneous nuclear ribonucleoprotein A1-like 3 , heterogeneous nuclear ribonucleoprotein A1B protein , heterogeneous nuclear ribonucleoprotein B2 protein , heterogeneous nuclear ribonucleoprotein core protein A1 , hnRNP A1-like 3 , hnRNP core protein A1-like 3 , nuclear ribonucleoprotein particle A1 protein , single-strand DNA-binding protein UP1 , single-strand RNA-binding protein , HDP-1 , helix destabilizing protein , topoisomerase-inhibitor suppressed , UP1 , unwinding protein 1 , HDP , hnRNP A1-gamma isoform , heterogeneous nuclear ribonucleoproteins A1 homolog
GENE ID | SPECIES |
---|---|
378453 | Danio rerio |
739306 | Pan troglodytes |
100101226 | Bombyx mori |
100195734 | Salmo salar |
380381 | Xenopus laevis |
496507 | Xenopus (Silurana) tropicalis |
3178 | Homo sapiens |
15382 | Mus musculus |
768103 | Sus scrofa |
505093 | Bos taurus |
29578 | Rattus norvegicus |
100359118 | Oryctolagus cuniculus |
100726972 | Cavia porcellus |
747284 | Pan troglodytes |
702977 | Macaca mulatta |
397751 | Xenopus laevis |