Use your antibodies-online credentials, if available.
No Products on your Comparison List.
Your basket is empty.
Find out more
Expression of HEXIM1 is induced by hexamethylene-bis-acetamide in vascular smooth muscle cells. Additionally we are shipping HEXIM1 Proteins (11) and HEXIM1 Kits (9) and many more products for this protein.
Showing 10 out of 137 products:
Human Polyclonal HEXIM1 Primary Antibody for WB - ABIN2801953
Ota, Suzuki, Nishikawa, Otsuki, Sugiyama, Irie, Wakamatsu, Hayashi, Sato, Nagai, Kimura, Makita, Sekine, Obayashi, Nishi, Shibahara, Tanaka, Ishii, Yamamoto, Saito, Kawai, Isono, Nakamura, Nagahari et al.: Complete sequencing and characterization of 21,243 full-length human cDNAs. ... in Nature genetics 2003
Show all 4 Pubmed References
Human Polyclonal HEXIM1 Primary Antibody for ELISA, WB - ABIN188667
Schulte, Czudnochowski, Barboric, Schönichen, Blazek, Peterlin, Geyer: Identification of a cyclin T-binding domain in Hexim1 and biochemical analysis of its binding competition with HIV-1 Tat. in The Journal of biological chemistry 2005
The 7SK RNA binds to Hexim1 and turns it into an inhibitor of the positive transcription elongation factor (show TSFM Antibodies) (P-TEFb (show CCNT1 Antibodies)). And in addition to its action on P-TEFb (show CCNT1 Antibodies), it plays a role in a variety of different mechanisms: it controls the stability of transcription factor components and assists binding of transcription factors to their targets.
We conclude that the degradation of NPM1 (show NPM1 Antibodies) and HEXIM1 through autophagy in certain AML (show RUNX1 Antibodies) subsets contributes to the activation of the BET pathway in these cells.
Identify a HEXIM1-containing ribonuclear protein complex composed also of DNA-PK, paraspeckle subunits, and the long non-coding RNA (lncRNA) NEAT1, which acts as a key nuclear regulator of DNA-mediated activation of innate immune response through the cGAS-STING pathway.
HMBA and derivative HMBA4a1 induce HEXIM1 activity, targeting several signaling pathways critical in tumorigenesis and metastasis.
HSP70 (show HSP70 Antibodies) activator shows similar activity as HMBA and 4a1 to induce HEXIM1 expression, suggesting that HMBA and 4a1 might be putative HSP70 (show HSP70 Antibodies) activators
Our results demonstrated that HEXIM1 exhibited the most consistent response to BET inhibitors in all of the settings examined, including tumors and surrogate tissues.
Suggest that greater tumor associated macrophage density, strong Hexim1 expression, strong SMAD2 (show SMAD2 Antibodies) expression, and mild SMAD7 (show SMAD7 Antibodies) expression play important roles in the progression of prostate adenocarcinoma.
Results show that HEXIM1 is a tumor suppressor in melanoma that responds to nucleotide stress by inhibiting transcription elongation of tumorigenic genes and stabilizing mRNA transcripts of other tumor suppressor genes.
Data indicate the binding of RNA-binding protein (show PTBP1 Antibodies) HEXIM with 7SKsnRNP complex comprising the non-coding RNA 7SK and proteins MePCE (show MEPCE Antibodies) and LARP7 (show LARP7 Antibodies).
PPM1G (show PPM1G Antibodies) phosphatase directly binds 7SK RNA and the kinase inhibitor Hexim1 once P-TEFb (show CCNT1 Antibodies) has been released from the 7SK snRNP (show LSM2 Antibodies).
The authors demonstrate that bovine hexamethylene bisacetamide-induced protein 1 (BHEXIM1) inhibits the bovine immunodeficiency virus-mediated BIV LTR transcription. In vivo and in vitro assays show direct binding of BHEXIM1 to the bovine cyclin T1 (show CCNT1 Antibodies).
Trypanosoma cruzi (T. cruzi) infected mice heterozygous for hexamethylene bis-acetamide inducible 1 (Hexim1) gene have compromised cardiac function, altered expression of both pro- and anti-inflammatory cytokines, and increased inflammation and fibrosis. The profound exacerbation of pathologic findings in the tissues of heart, lung, spleen, and intestines suggests a protective role for Hexim1 in T. cruzi infection.
Decreased Hexim-1 expression does not alter cholesterol metabolism in ApoE (show APOE Antibodies) null background after high fat diet. However, it promotes stable atherosclerotic plaque and decreased steatosis by promoting the anti-inflammatory TGFbeta (show TGFB1 Antibodies) pathway and blocking the expression of the inducible and pro-inflammatory expression of SOCS3 (show SOCS3 Antibodies) respectively.
Hexim1 selectively modulates leptin (show LEP Antibodies)-mediated signal transduction pathways in the hypothalamus.
conclude that HEXIM1 could prevent RV hypertrophy, at least in part, via suppression of myocardial angiogenesis through down-regulation of HIF-1alpha (show HIF1A Antibodies) and VEGF (show VEGFA Antibodies) in the myocardium under hypoxic condition
HEXIM1 re-expression results in the induction of angiogenesis that allows for the co-ordination of tissue growth and angiogenesis during physiological hypertrophy
re-expression of HEXIM1 in mammary epithelial cells resulted in inhibition of metastasis to the lung
a crucial role for the HEXIM1/P-TEFb (show CCNT1 Antibodies) pathway in the regulation of satellite cell-mediated muscle regeneration and identify HEXIM1 as a potential therapeutic target for degenerative muscular diseases.
Our findings underscore the critical role of CLP-1 (show CNNM1 Antibodies) in remodeling of the genetic response during hypertrophy and fibrosis.
these results show that the improvement in cardiac function in CLP-1 (show CNNM1 Antibodies)(+/-) mice after ischemia-reperfusion injury is achieved through the potentiation of redox signaling.
CLP-1 (show CNNM1 Antibodies) and the HAND transcription factors may be part of a genetic program critical to proper heart development, and their perturbation can lead to cardiomyopathy
Expression of this gene is induced by hexamethylene-bis-acetamide in vascular smooth muscle cells. This gene has no introns.
hexamethylene bis-acetamide inducible 1
, protein HEXIM1
, protein HEXIM1-like
, protein HEXIM
, cardiac lineage protein 1
, estrogen down-regulated gene 1 protein
, hexamethylene bis-acetamide-inducible protein 1
, hexamethylene bisacetamide-inducible protein
, hexamethylene-bis-acetamide-inducible transcript 1
, hexamthylene bis-acetamide inducible 1
, menage a quatre 1
, menage a quatre protein 1
, HMBA-inducible 1