anti-Holliday Junction Recognition Protein (HJURP) Antibodies

Centromeric protein that plays a central role in the incorporation and maintenance of histone H3-like variant CENPA at centromeres. Additionally we are shipping HJURP Kits (3) and HJURP Proteins (3) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
HJURP 381280 Q6PG16
HJURP 55355 Q8NCD3
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Top anti-HJURP Antibodies at antibodies-online.com

Showing 10 out of 37 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Human Rabbit Un-conjugated ELISA, WB Western blot analysis of HJURP using COLO205 whole cell lysates 100 μL Log in to see 11 to 12 Days
$390.77
Details
Human Rabbit Un-conjugated FACS, IHC (p), WB Western blot analysis in Jurkat cell line lysates (35ug/lane). HJURP Antibody immunohistochemistry analysis in formalin fixed and paraffin embedded human thyroid tissue followed by peroxidase conjugation of the secondary antibody and DAB staining. 400 μL Log in to see 2 to 3 Days
$515.63
Details
Human Rabbit Un-conjugated ELISA, WB   100 μL Log in to see 11 to 13 Days
$335.04
Details
Human Rabbit Un-conjugated IF, IHC (p), WB Western blot analysis of Lane 1: RT-4, Lane 2: U-251 MG, Lane 3: Human Plasma, Lane 4: Liver, Lane 5: Tonsil with HJURP polyclonal antibody  at 1:250-1:500 dilution. Immunofluorescent staining of human cell line A-431 with HJURP polyclonal antibody  at 1-4 ug/mL dilution shows positivity in nucleus, nucleoli. 100 μL Log in to see 11 to 12 Days
$577.33
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Human Rabbit Un-conjugated FACS, IHC, ELISA, WB   200 μL Log in to see 11 to 16 Days
$658.43
Details
Human Rabbit Alkaline Phosphatase (AP) FACS, IHC, ELISA, WB   200 μL Log in to see 11 to 14 Days
$1,101.83
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Human Rabbit HRP FACS, IHC, ELISA, WB   200 μL Log in to see 11 to 14 Days
$1,101.83
Details
Human Rabbit APC FACS, IHC, ELISA, WB   200 μL Log in to see 11 to 14 Days
$1,101.83
Details
Human Rabbit FITC FACS, IHC, ELISA, WB   200 μL Log in to see 11 to 14 Days
$1,101.83
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Human Rabbit PE FACS, IHC, ELISA, WB   200 μL Log in to see 11 to 14 Days
$1,101.83
Details

Top referenced anti-HJURP Antibodies

  1. Human Polyclonal HJURP Primary Antibody for ICC, IF - ABIN4318544 : Shuaib, Ouararhni, Dimitrov, Hamiche: HJURP binds CENP-A via a highly conserved N-terminal domain and mediates its deposition at centromeres. in Proceedings of the National Academy of Sciences of the United States of America 2010 (PubMed)
    Show all 3 Pubmed References

More Antibodies against HJURP Interaction Partners

Mouse (Murine) Holliday Junction Recognition Protein (HJURP) interaction partners

  1. Study showed major differences in gene copy number in natural populations. CWC22, SFI1, and HJURP are highly conserved genes with the most copy-number variation. They all exhibit population-specific expansion patterns, perhaps for local adaptations.

Human Holliday Junction Recognition Protein (HJURP) interaction partners

  1. these data define a novel molecular mechanism underlying the assembly of CENP-T onto the centromere by a temporally regulated HJURP-CENP-T interaction.

  2. H3.3 chaperones HIRA and DAXX promote ectopic CENP-A deposition.

  3. HJURP expression was higher in HCC tissues than in para-tumor tissues. Moreover, ectopic HJURP expression facilitated the proliferation of HCC cells, whereas the depletion of HJURP resulted in decreased cell growth in vitro and in vivo. Furthermore, the effects of HJURP silencing were reversed by p21 knockdown.

  4. Increased expression of HJURP was identified as an independent negative prognostic biomarker for patients with advanced serous ovarian cancer.

  5. during the CENP-A/H4 deposition process, the chaperone HJURP protects various substructures of the dimer, serving both as a folding and binding chaperone

  6. Functional p53 elicits a cell cycle arrest response, whereas, in p53-null transformed cells, the absence of arrest enables the loss of HJURP to induce severe aneuploidy and, ultimately, apoptotic cell death

  7. An increased occurrence of hepatocellular carcinoma was consistently associated with A/C or C/C genotypes of the non-synonymous SNP rs3771333 compared with the A/A genotype in both the Fusui and Haimen populations.

  8. Authors propose that this centromere expansion activity reflects the functional properties of HJURP, which uses this activity to contribute to the plastic establishment of a centromeric chromatin structure.

  9. 3 biomarkers in 44 patients with in situ breast cancers were evaluated: TG2 (transglutaminase 2), HJURP (Holliday junction recognition protein), and HIF-1alpha (hypoxia inducible factor-1 alpha).

  10. On the basis of our findings, we propose that HJURP serves a dual chaperone function in coordinating CenH3(CENP-A) and CENP-C recruitment.

  11. HJURP can discriminate favorable and unfavorable outcome within the luminal A subtype, outperforming the currently utilized proliferation marker Ki67, as an independent prognostic marker for luminal A patients.

  12. Phosphorylation state of HJURP controls its centromeric recruitment. HJURP binding to DNA promotes loading of CenH3CENP-A at centromeres.

  13. The study describes a novel function for human centromeric long non-coding RNAs in the recruitment of HJURP and CENP-A, implicating RNA-based chaperone targeting in histone variant assembly.

  14. The levels of the EDNRB, HJURP and p60/CAF-1 proteins were strongly associated with overall survival in high-grade gliomas patients (p<0.001, p<0.001 and p=0.002, respectively), whereas the one of PDLI4 was not (P=0.11).

  15. Mis18beta binds with and specifies the centromere localization of HJURP.

  16. HJURP has an important role in the maintenance of extremely proliferative cells of high-grade gliomas

  17. a mechanism whereby the CENP-A pre-nucleosomal complex achieves assembly of the octameric CENP-A nucleosome through the dimerization of the CENP-A chaperone HJURP.

  18. Downregulation of HJURP in young cells led to premature senescence. p53 knockdown, but not p16 knockdown, abolished senescence phenotypes caused by HJURP reduction.

  19. And-1 together with HJURP regulates the assembly of new CENP-A onto centromeres.

  20. stringent regulation of HJURP and SCM3 expression are critical for genome stability.

HJURP Antigen Profile

Protein Summary

Centromeric protein that plays a central role in the incorporation and maintenance of histone H3-like variant CENPA at centromeres. Acts as a specific chaperone for CENPA and is required for the incorporation of newly synthesized CENPA molecules into nucleosomes at replicated centromeres. Prevents CENPA-H4 tetramerization and prevents premature DNA binding by the CENPA-H4 tetramer. Directly binds Holliday junctions (By similarity).

Gene names and symbols associated with HJURP

  • Holliday junction recognition protein (Hjurp) antibody
  • Holliday junction recognition protein (HJURP) antibody
  • C330011F01Rik antibody
  • FAKTS antibody
  • Gm975 antibody
  • hFLEG1 antibody
  • Mfleg1 antibody
  • MGC66590 antibody
  • URLC9 antibody

Protein level used designations for HJURP

Holliday junction recognition protein , OTTMUSP00000022762 , OTTMUSP00000038458 , fetal liver expressing gene 1 protein homolog , 14-3-3-associated AKT substrate , fetal liver expressing gene 1 , fetal liver-expressing gene 1 protein , up-regulated in lung cancer 9

GENE ID SPECIES
381280 Mus musculus
55355 Homo sapiens
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