anti-Homeobox C8 (HOXC8) Antibodies

Human Homeobox C8 (HOXC8) interaction partners

1. Results show that HOXC8 is consistently downregulated in stem/progenitor cells of all breast molecular subtypes, thus representing a putative tumor suppressor candidate. Also, downregulated expression of HOXC8 is associated with DNA methylation at the gene promoter and expression of miR196 family members. Taken together, study establishes HOXC8 as a suppressor of stemness and transformation in the mammary gland lineage.

2. Owing to the overexpression of Homeobox C8 (HOXC8), findings implied that HOXC8 is involved in the progression of epithelial ovarian cancer (EOC) and could be a potential therapeutical approach of EOC.

3. High expression of HOXC8 is associated with laryngeal squamous cell carcinoma.

4. HOXC8 knockdown led to inhibition of tumor cell proliferation and migration in vitro by inhibiting MMP-9 expression and tumor growth in vivo. The results strongly suggest that HOXC8 is involved in the tumorigenesis of osteosarcoma and might serve as a novel predictor for patients' outcome.

5. embigin is regulated by HOXC8 and its loss plays an important role in the progression of breast tumors

6. Ectopic expression of HoxC8 inhibits nasopharyngeal carcinoma cell growth in vitro and in vivo, modulates glycolysis and regulates the expression of tricarboxylic acid (TCA) cycle-related genes.

7. Upregulated HOXC8 expression was associated with oxaliplatin resistance in hepatocellular carcinoma.

8. miR-196a was over-expressed in cervical cancer cells, while an absence of HOXC8 expression was observed.

9. HOXC8 promotes breast tumorigenesis by transcriptionally facilitating cadherin-11 expression.

10. HOXC8 can be used as a prognostic marker in esophageal squamous cell carcinoma

11. HOXC8 expression is inversely related to pancreatic ductal adenocarcinoma progression and metastasis.

12. a complex role for HOXC8 in prostate cancer, promoting invasiveness while inhibiting AR-mediated gene induction at androgen response element-regulated genes associated with differentiated function of the prostate

13. Ratio of microRNA to HOXC8 mRNA may be an indicator of the metastatic capability of breast tumors.

14. overexpression associated with loss of tumor differentiation in human prostate cancer; may play role in acquisition of invasive/metastatic phenotype

15. Androgen-independent cell line DU145 cells lack PLZF gene expression, resulting in the upregulation of Pbx1 and HoxC8 expression. The Pbx1-HoxC8 heterocomplex may lead to androgen-independent growth in prostate cancer.

Mouse (Murine) Homeobox C8 (HOXC8) interaction partners

1. In presence of these inducing agents, lipid accumulation as well as expression of HoxA1, HoxA5, HoxC4 &HoxC8 markedly enhanced. Irrespective of presence or absence of T3, insulin down regulates HoxA10. T3 results in over expression of HoxA5, HoxC4 and HoxC8 genes, whereas insulin up regulates expression of only HoxC8

2. Hoxc8 initiates an ectopic mammary program by regulating Fgf10 and Tbx3 expression and Wnt/beta-catenin signaling

3. Cdx1 regulation on HoxC8 expression and suggest the possibility that the temporal changes in Cdx activity levels during gastrulation, combined with differential DNA binding affinity, might play a role in the establishment of Hox sequential activation.

4. Hoxc8 downregulates Mgl1 tumor suppressor gene expression and reduces its concomitant function on cell adhesion.

5. Data provide the basis for future studies in pathogenesis of cartilage defects in Hoxc8- and Hoxd4-transgenic mice.

6. Hoxc8, when over-expressed in C3H10T1/2 or C2C12 cells, suppressed basal Smad6 promoter activity and its mRNA expression

7. Hoxc8 regulation is essential for osteoblast differentiation.

8. Pcna is a direct downstream target of Hoxc8.

9. interaction with smad1 stimulates bone development

10. remodeling of Hox regulatory elements in different species has played a significant role in generating morphological diversity

11. In mice, Hoxc8 has a role in the formation of the vertebrae and ribs and may be involved in the differentiation of the kidney.

12. OPN is a direct transcriptional target of Hoxc8

13. Raldh2L-/- phenotype relies in part on the deregulation of Hoxc8, which in turn regulates the RA receptor RARbeta

14. the genes described here should aid in the understanding of global regulatory networks of Hox genes and to provide valuable insight into the molecular basis of Hoxc8 in development and carcinogenesis

15. Precise temporal expression of Hoxc8 is important for determining the correct identity of the vertebral column in early embryos.

16. These studies document a functional role for Ap2delta in recruiting histone methyltransferases to specific gene targets, such as Hoxc8.

17. These results indicate that the 16 amino acid third helix is the key element responsible for the membrane transduction activity of Hoxc8 proteins.

18. Our results provide evidence for a role for Hoxc8 in controlling cell cycle progression

Xenopus laevis Homeobox C8 (HOXC8) interaction partners

1. Cdx1 binds directly these responsive elements during embryogenesis, as part of the mechanism for the timely activation of HoxC8 expression.

Zebrafish Homeobox C8 (HOXC8) interaction partners

1. Remodeling of Hox regulatory elements in different species has played a significant role in generating morphological diversity.