HtrA Serine Peptidase 4 Proteins (HTRA4)

HTRA4 encodes a member of the HtrA family of proteases. Additionally we are shipping HtrA Serine Peptidase 4 Antibodies (41) and HtrA Serine Peptidase 4 Kits (9) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
HTRA4 203100 P83105
HTRA4 330723 A2RT60
Rat HTRA4 HTRA4 306564 D3ZKF5
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Top HtrA Serine Peptidase 4 Proteins at antibodies-online.com

Showing 6 out of 8 products:

Catalog No. Origin Source Conjugate Images Quantity Delivery Price Details
Insect Cells Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg 60 Days
$9,626.73
Details
Insect Cells Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg 60 Days
$9,626.73
Details
Insect Cells Human His tag   5 μg 6 to 7 Days
$482.70
Details
Escherichia coli (E. coli) Human His tag   5 μg 6 to 7 Days
$457.84
Details
Wheat germ Human GST tag 2 μg 11 to 12 Days
$338.33
Details
Escherichia coli (E. coli) Human Un-conjugated   1 mg 11 to 18 Days
$1,762.47
Details

HTRA4 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , ,
,
Mouse (Murine)

Top referenced HtrA Serine Peptidase 4 Proteins

  1. Human HTRA4 Protein expressed in Insect Cells - ABIN807967 : Singh, Zhao, Chen, Wang, Li, Kaituu-Lino, Tong, Nie: Human HtrA4 Expression Is Restricted to the Placenta, Is Significantly Up-Regulated in Early-Onset Preeclampsia, and High Levels of HtrA4 Cause Endothelial Dysfunction. in The Journal of clinical endocrinology and metabolism 2015 (PubMed)

More Proteins for HtrA Serine Peptidase 4 (HTRA4) Interaction Partners

Human HtrA Serine Peptidase 4 (HTRA4) interaction partners

  1. The HtrA1-PDZ and HtrA4-PDZ as well as HtrA2-PDZ and HtrA3-PDZ respond similarly to different halogen substitutions of peptide; -Br substitution at R2-position and -I substitution at R4-position are most effective in improving peptide selectivity for HtrA1-PDZ/HtrA4-PDZ and HtrA2-PDZ/HtrA3-PDZ, respectively; -F substitution would not address substantial effect on peptide selectivity for all the 4 domains

  2. the aberrant expression of HTRA1 or HTRA4 may be involved in the onset of preeclampsia, and increased HTRA1 or HTRA4 expression may affect trophoblast functions.

  3. GATA3 knockdown elevated HtrA4 expression in BeWo and JEG-3 trophoblast cell lines and enhanced the invasion activities of both lines. This study uncovered a new GATA3 function in placenta as a negative regulator of GCM1 activity and trophoblastic invasion.

  4. HtrA4 represents a novel placenta-specific serine protease that is altered specifically in early-onset preeclampsia with potential causal roles in endothelial dysfunction and disease development.

  5. Conditioned media from these two cell lines after decidualization treatment suppress HtrA4-expressing JAR cell invasion in an HtrA1- or HtrA3-dependent manner.

  6. Data suggest that increased HtrA4 (and HtrA1) in placenta tissues may be involved in onset of pre-eclampsia; elevated level of HtrA4 (but not HtrA1) in sera has potential as biomarker for pre-eclampsia.

  7. study reveals a novel function of GCM1 and HtrA4 in regulation of trophoblast invasion and that abnormal HrtA4 expression may contribute to shallow trophoblast invasion in preeclampsia

  8. FLJ90724 or HTRA4 is a member of the HtrA family of proteases

Mouse (Murine) HtrA Serine Peptidase 4 (HTRA4) interaction partners

  1. mice, featuring a conditional null allele of HtrA4, may provide a valuable tool to investigate the role of HtrA4 in development and pathogenesis of coronary heart disease and preeclampsia.

HtrA Serine Peptidase 4 (HTRA4) Protein Profile

Protein Summary

This gene encodes a member of the HtrA family of proteases. The encoded protein contains a putative signal peptide, an insulin growth factor binding domain, a Kazal protease inhibitor domain, a conserved trypsin domain and a PDZ domain. Based on studies on other related family members, this enzyme may function as a secreted oligomeric chaperone protease to degrade misfolded secretory proteins. Other human HtrA proteins have been implicated in arthritis, tumor suppression, unfolded stress response, apoptosis, and aging.

Gene names and symbols associated with HTRA4

  • HtrA serine peptidase 4 (HTRA4)
  • HtrA serine peptidase 4 (Htra4)
  • B430206E18Rik protein
  • RGD1306242 protein

Protein level used designations for HTRA4

HtrA serine peptidase 4 , probable serine protease HTRA4-like , high-temperature requirement factor A4 , probable serine protease HTRA4 , serine protease HTRA4 , serine protease HTR4

GENE ID SPECIES
472743 Pan troglodytes
475580 Canis lupus familiaris
700875 Macaca mulatta
100156083 Sus scrofa
100392979 Callithrix jacchus
100605000 Nomascus leucogenys
203100 Homo sapiens
514946 Bos taurus
330723 Mus musculus
306564 Rattus norvegicus
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