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The protein encoded by HABP2 is an extracellular serine protease that binds hyaluronic acid and is involved in cell adhesion.
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Human Monoclonal HABP2 Primary Antibody for IP, ELISA - ABIN516334
Altmäe, Kallak, Fridén, Stavreus-Evers: Variation in hyaluronan-binding protein 2 (HABP2) promoter region is associated with unexplained female infertility. in Reproductive sciences (Thousand Oaks, Calif.) 2011
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Human Polyclonal HABP2 Primary Antibody for IHC, IHC (p) - ABIN4316533
Bachmann, Burté, Pramana, Conte, Brown, Orimadegun, Ajetunmobi, Afolabi, Akinkunmi, Omokhodion, Akinbami, Shokunbi, Kampf, Pawitan, Uhlén, Sodeinde, Schwenk, Wahlgren, Fernandez-Reyes, Nilsson: Affinity proteomics reveals elevated muscle proteins in plasma of children with cerebral malaria. in PLoS pathogens 2014
Regulation of gene expression by FSAP in vascular smooth muscle/endothelial cells accounts for its vasculo-regulatory properties.
The extent of CAC (show CA2 Antibodies) in women is positively associated with total FSAP, but negatively associated with the specific activity of FSAP suggesting that FSAP may play a role in the evolution of CVD in women.
Report peptide substrates used in determining substrate specificity of Factor VII activating protease.
Two of 20 probands from families with history of PTC (show F9 Antibodies) and breast carcinoma (BC) were evaluated by whole exome sequencing (WES) revealing HABP2 p.G534E.
No significant association was found between rs11196288 and early-onset ischemic stroke, large artery atherosclerotic stroke, or small vessel disease stroke. rs11196288 presented significant effect on late-onset SVD (show KCNJ13 Antibodies) stroke susceptibility in the older population.
study on a wide series of familial non-medullary thyroid cancers indicates that the HABP2(G534E) variant is frequent, but does not segregate with the disease
Letter: G534E variant in HABP2 is not associated with non-medullary thyroid cancer in the Spanish population.
Study showed that lower FSAP antigen plasma levels were associated with a higher chance of arterial recanalization after tissue plasminogen activator (show PLAT Antibodies) treatment, suggesting an involvement of FSAP in tissue plasminogen activator (show PLAT Antibodies)-induced clot (show TXNDC17 Antibodies) lysis. FSAP antigen determination might be useful in predicting tissue plasminogen activator (show PLAT Antibodies) response in stroke patients.
HABP2 polymorphisms are not associated with thyroid cancer.
the promoter activity, which could phenocopy changes in Habp2 mRNA in response to TGF-beta (show TGFB1 Antibodies), was found to be located in the 177-bp region upstream of the transcription start site, and this region did not contain any SMAD (show SMAD1 Antibodies) binding sites.
FSAP deficiency causes an increase in CCL2 (show CCL2 Antibodies) expression and CCL2 (show CCL2 Antibodies)-mediated infiltration of leukocytes into the injured vessel
Lack of endogenous FSAP impaired the formation of stable, occlusive thrombi in mice.
Results show that the lack of FSAP in mice worsens the outcome of stroke; in the absence of FSAP there was a stronger inflammatory response and lower cell survival due to insufficient activation of the PI3K/AKT (show AKT1 Antibodies) pathway
Lower FSAP expression is associated with enhanced liver fibrosis and inflammation in patients with chronic hepatic disorders and murine experimental liver injury.
Data indicate that FSAP mediates proteolytic cleavage and activation of bone morphogenetic protein-2 (BMP-2 (show BMP2 Antibodies)).
Hyaluronic acid binding protein 2 (HABP2) negatively regulates vascular integrity via activation of protease-activated receptor/RhoA (show RHOA Antibodies)/Rho kinase (show ROCK2 Antibodies) signaling. It represents a potential therapeutic target for syndromes of increased vascular permeability.
The protein encoded by this gene is an extracellular serine protease that binds hyaluronic acid and is involved in cell adhesion. The encoded protein is synthesized as a single chain, but then undergoes an autoproteolytic event to form the functional heterodimer. Further autoproteolysis leads to smaller, inactive peptides. This protease is known to cleave urinary plasminogen activator, coagulation factor VII, and the alpha and beta chains of fibrinogen, but not prothrombin, plasminogen, or the gamma chain of fibrinogen. Two transcript variants encoding different isoforms have been found for this gene.
hyaluronan binding protein 2
, hyaluronan-binding protein 2-like
, factor VII activating protein
, factor VII-activating protease
, factor seven-activating protease
, hepatocyte growth factor activator-like protein
, hyaluronan-binding protein 2
, hyaluronic acid binding protein 2
, plasma hyaluronan binding protein
, plasma hyaluronan-binding protein
, hyaduronic acid-binding protein 2