anti-Hyaluronan and Proteoglycan Link Protein 1 (HAPLN1) Antibodies

Stabilizes the aggregates of proteoglycan monomers with hyaluronic acid in the extracellular cartilage matrix.. Additionally we are shipping HAPLN1 Proteins (11) and and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
HAPLN1 1404 P10915
HAPLN1 12950 Q9QUP5
HAPLN1 29331  
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Top anti-HAPLN1 Antibodies at antibodies-online.com

Showing 10 out of 68 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Cow Rabbit Un-conjugated WB WB Suggested Anti-HAPLN1 Antibody Titration:  0.2-1 ug/ml  ELISA Titer:  1:62500  Positive Control:  NCI-H226 cell lysate HAPLN1 is strongly supported by BioGPS gene expression data to be expressed in Human NCI-H226 cells WB Suggested Anti-HAPLN1  Antibody Titration: 0.2-1 µg/mL ELISA Titer: 1:.2500  Positive Control: NCI-H226 cell lysate  HAPLN1 is strongly supported by BioGPS gene expression data to be expressed in Human NCI-H226 cells 100 μL Log in to see 2 to 3 Days
$319.00
Details
Human Rabbit Un-conjugated FACS, IHC (p), WB HAPLN1 Antibody (N-term) (ABIN653748) western blot analysis in MCF-7,Jurkat,HepG2 cell line lysates (35 µg/lane).This demonstrates the HAPLN1 antibody detected the HAPLN1 protein (arrow). HAPLN1 Antibody (N-term) (ABIN653748) IHC analysis in formalin fixed and paraffin embedded prostate carcinoma followed by peroxidase conjugation of the secondary antibody and DAB staining. This data demonstrates the use of the HAPLN1 Antibody (N-term)for immunohistochemistry. 400 μL Log in to see 10 to 11 Days
$385.00
Details
Bat Rabbit Un-conjugated WB 50 μg Log in to see 11 to 14 Days
$551.83
Details
Human Rabbit Un-conjugated IHC, IHC (p), WB Immunohistochemistry-Paraffin: HAPLN1 Antibody [NBP1-85443] - Staining of human bronchus shows strong cytoplasmic positivity in cartilage. Western Blot: HAPLN1 Antibody [NBP1-85443] - Lane 1: Marker [kDa] 230, 130, 95, 72, 56, 36, 28, 17, 11.Lane 2: Human cell line RT-4 0.1 mL Log in to see 10 to 13 Days
$494.38
Details
Human Rabbit Un-conjugated ICC, IF, IHC, IHC (p), WB Immunocytochemistry/Immunofluorescence: HAPLN1 Antibody (SY02-17)  - Staining HAPLN1 in BT-20 cells (green). The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS. Immunocytochemistry/Immunofluorescence: HAPLN1 Antibody (SY02-17)  - Staining HAPLN1 in HUVEC cells (green). The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS. 100 μL Log in to see 34 Days
$375.73
Details
Human Rabbit Un-conjugated IF/ICC, IHC, WB Western blot analysis of extracts of various cell lines, using HAPLN1 antibody (ABIN5973979) at 1/1000 dilution. Immunohistochemistry of paraffin-embedded human liver cancer using HAPLN1 antibody (ABIN5973979) at dilution of 1/100 (40x lens). 100 μL Log in to see 11 to 16 Days
$426.40
Details
Human Rabbit Un-conjugated ELISA, ICC, IF, IHC, WB Western blot analysis of HAPLN1 using HepG2 whole cell lysates ABIN6274013 staining HepG2 by IF/ICC. The sample were fixed with PFA and permeabilized in 0.1% Triton X-100,then blocked in 10% serum for 45 minutes at 25°C. The primary antibody was diluted at 1/200 and incubated with the sample for 1 hour at 37°C. An Alexa Fluor 594 conjugated goat anti-rabbit IgG (H+L) Ab, diluted at 1/600, was used as the secondary antibody. 100 μL Log in to see 11 to 12 Days
$390.77
Details
Human Rabbit Un-conjugated IF, IHC, WB Western blot analysis of extracts of various cell lines, using HAPLN1 antibody. Immunohistochemistry of paraffin-embedded human liver cancer using HAPLN1 antibody. 200 μL Log in to see 12 to 14 Days
$438.90
Details
Human Rabbit Un-conjugated WB Western Blot: HAPLN1 Antibody [NBP1-59150] - NCI-H226 cell lysate, concentration 0.2-1 ug/ml. 100 μL Log in to see 8 to 11 Days
$488.73
Details
Human Rabbit Un-conjugated IHC, WB Western blot analysis of extracts of various cell lines, using HAPLN1 antibody. Immunohistochemistry of paraffin-embedded rat liver using HAPLN1 antibody at dilution of 1:100 (x40 lens). 100 μL Log in to see 11 to 13 Days
$366.77
Details

Top referenced anti-HAPLN1 Antibodies

  1. Human Polyclonal HAPLN1 Primary Antibody for FACS, IHC (p) - ABIN653748 : Wheeler, Metter, Tanaka, Absher, Higgins, Zahn, Wilhelmy, Davis, Singleton, Myers, Ferrucci, Kim: Sequential use of transcriptional profiling, expression quantitative trait mapping, and gene association implicates MMP20 in human kidney aging. in PLoS genetics 2009 (PubMed)
    Show all 3 Pubmed References

  2. Human Polyclonal HAPLN1 Primary Antibody for WB - ABIN4892110 : Eskici, Erdem-Ozdamar, Dayangac-Erden: The altered expression of perineuronal net elements during neural differentiation. in Cellular & molecular biology letters 2018 (PubMed)

More Antibodies against HAPLN1 Interaction Partners

Zebrafish Hyaluronan and Proteoglycan Link Protein 1 (HAPLN1) interaction partners

  1. Hapln1a-ECM stabilizes the secreted growth factor Semaphorin3d (Sema3d), which has been independently shown to mediate Cx43 dependent phenotypes during regeneration.

  2. Hapln1a has a critical role in connexin43-dependent growth and patterning in the regenerating fin skeleton

  3. The cloning and characterization of crtl1 and its expression during embryogenesis are reported.

Cow (Bovine) Hyaluronan and Proteoglycan Link Protein 1 (HAPLN1) interaction partners

  1. stimulates proteoglycan and types II and IX collagens in intervertebral disc cells - stimulates synthesis of matrix molecules

Human Hyaluronan and Proteoglycan Link Protein 1 (HAPLN1) interaction partners

  1. HAPLN1 is produced in bone marrow stromal cells from multiple myeloma patients and can activate bortezomib-resistant NF-kappaB.

  2. HAPLN1 reflects a signaling network leading to stemness, mesenchymal commitment and hepatocellular carcinoma progression

  3. CSGalNAcT-1 and Hapln-1 may play important roles in the pathogenesis of Kashin-Beck disease and osteoarthritis.

  4. HAPLN1 is overexpressed in metastatic melanoma and is secreted exclusively by the tumor cells

  5. Single-nucleotide polymorphism in the hyaluronan and proteoglycan link protein 1 (HAPLN1) gene is associated with spinal osteophyte formation and disc degeneration in Japanese women.

  6. An in vitro model of perineuronal nets has been developed demonstrating that cartilage link protein (along with hyaluronan synthase) are necessary for their formation.

  7. link protein may function as a stabilizer of the interaction between aggrecan and hyaluronan in cartilage and between versican and hyaluronan in many tissues

  8. SOX9 is a key regulator of CRTL1

  9. cLP and versican did not bind directly to each other in solution yet formed ternary complexes with hyaluronan

  10. Overexpression of HAPLN1 and its SP-IgV domain increases tumorigenic properties of mesothelioma. Thus, targeting the SP-IgV domain may be one of the therapeutic approaches in cancer treatment.

Mouse (Murine) Hyaluronan and Proteoglycan Link Protein 1 (HAPLN1) interaction partners

  1. Aggrecan, link protein and TN-R were identified to be essential for the neuroprotective properties of the perineuronal net.

  2. Mef2c regulates transcription of the extracellular matrix protein cartilage link protein 1 in the developing murine heart.

  3. our findings demonstrate that the formation of perineuronal nets triggered by neuronal Crtl1 synthesis is a key event in the diminuation of plasticity in the adult CNS

  4. there is a general and systemic function of link protein in the organization of extracellular matrix in a number of tissues, possibly interacting with other proteoglycans, such as versican, brevican, and neurocan

  5. Data suggest that the reported temporal co-expression of cartilage link protein and neurocan in developing brain implicates the possibility of a cooperative function of these molecules.

  6. reduced versican expression may contribute to a subset of the cardiac abnormalities observed in the Crtl1(-/-) mouse.

HAPLN1 Antigen Profile

Protein Summary

Stabilizes the aggregates of proteoglycan monomers with hyaluronic acid in the extracellular cartilage matrix.

Gene names and symbols associated with HAPLN1

  • hyaluronan and proteoglycan link protein 1 (HAPLN1) antibody
  • hyaluronan and proteoglycan link protein 1a (hapln1a) antibody
  • hyaluronan and proteoglycan link protein 1 (Hapln1) antibody
  • BB099155 antibody
  • CLP antibody
  • Crtl1 antibody
  • Crtl1l antibody
  • CTRL1 antibody
  • hapln1 antibody
  • LP antibody
  • LP-1 antibody
  • wu:fc26f11 antibody
  • wu:fc37g04 antibody
  • wu:fc50e12 antibody
  • wu:fc55h01 antibody

Protein level used designations for HAPLN1

hyaluronan and proteoglycan link protein 1 , cartilage linking protein 1 , fc26f11 , fc37g04 , fc50e12 , fc55h01 , hyaluronan proteoglycan link protein 1 , cartilage link protein , cartilage-link protein , cartilage-linking protein 1 , proteoglycan link protein , Cartilage link protein , cartilage link protein 1 , link protein , LP , link protein precursor (AA -15 to 339)

GENE ID SPECIES
461765 Pan troglodytes
488921 Canis lupus familiaris
493635 Danio rerio
712501 Macaca mulatta
100442758 Pongo abelii
100605865 Nomascus leucogenys
281717 Bos taurus
1404 Homo sapiens
12950 Mus musculus
29331 Rattus norvegicus
396475 Gallus gallus
100034208 Equus caballus
445513 Sus scrofa
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