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The enzyme encoded by HAGH is classified as a thiolesterase and is responsible for the hydrolysis of S-lactoyl-glutathione to reduced glutathione and D-lactate.
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Human Monoclonal HAGH Primary Antibody for WB - ABIN1882252
Antognelli, Baldracchini, Talesa, Costantini, Zucchi, Mearini: Overexpression of glyoxalase system enzymes in human kidney tumor. in Cancer journal (Sudbury, Mass.) 2006
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Glo2, together with Glo1 (show GLO1 Antibodies), represents a novel mechanism in prostate cancer progression as part of a pathway driven by PTEN/PI3K (show PIK3CA Antibodies)/AKT (show AKT1 Antibodies)/mTOR (show FRAP1 Antibodies) signaling.
This article reports for the first time a possible additional role of Glo2 that, after interacting with a target protein, is able to promote S-glutathionylation.
Studies indicate that the most extensively investigated The most extensively investigated glyoxalase enzymes are glyoxalase I (show GLO1 Antibodies) and glyoxalase II (Glo1 (show GLO1 Antibodies) and Glo2).
This study suggested that HAGH, rs11859266 and rs3743852 showed significant associations with schizophrenia in males at allelic and genotype levels.
No association between genetic variants of the HAGH gene and autism spectrum disorder was found.
hydroxyacylglutathione hydrolase (HAGH) gene encodes both cytosolic and mitochondrial forms of glyoxalase II
Overexpression of glyoxalase II is associated with kidney tumor
Data show that the GLX2 gene, which encodes glyoxalase II enzyme, is up-regulated by p63 (show RPE65 Antibodies) and p73 (show TP73 Antibodies).
In androgen-dependent prostate cancer cells, testosterone upregulates GLO2 mRNA levels. In androgen-independent prostate cancer cells, it downregulates GLO2 mRNA.
Human glyoxalase II contains an Fe(II)Zn(II) center but is active as a mononuclear Zn(II) enzyme
The enzyme encoded by this gene is classified as a thiolesterase and is responsible for the hydrolysis of S-lactoyl-glutathione to reduced glutathione and D-lactate. Two transcript variants encoding different isoforms have been found for this gene.
, glyoxylase II
, glx II
, glyoxalase II
, glyoxylase 2
, hydroxyacylglutathione hydrolase, mitochondrial
, round spermatid protein RSP29
, hydroxyacylglutathione hydroxylase
, Germ cell-specific protein
, Glx II
, Glyoxalase II