Hydroxymethylbilane Synthase (HMBS) ELISA Kits

HMBS encodes a member of the hydroxymethylbilane synthase superfamily. Additionally we are shipping Hydroxymethylbilane Synthase Antibodies (85) and Hydroxymethylbilane Synthase Proteins (12) and many more products for this protein.

list all ELISA KIts Gene Name GeneID UniProt
HMBS 3145 P08397
HMBS 25709  
HMBS 15288 P22907
How to order from antibodies-online
  • +1 877 302 8632
  • +1 888 205 9894 (toll-free)
  • Order online
  • orders@antibodies-online.com

Top Hydroxymethylbilane Synthase ELISA Kits at antibodies-online.com

Showing 4 out of 9 products:

Catalog No. Reactivity Sensitivity Range Images Quantity Supplier Delivery Price Details
Human 0.26 ng/mL 0.78 ng/mL - 50 ng/mL 96 Tests Log in to see 13 to 16 Days
  96 Tests Log in to see 15 to 18 Days
  96 Tests Log in to see 15 to 18 Days
  96 Tests Log in to see 15 to 18 Days

More ELISA Kits for Hydroxymethylbilane Synthase Interaction Partners

Human Hydroxymethylbilane Synthase (HMBS) interaction partners

  1. After a diagnostic odyssey, his urine porphobilinogen was found to be significantly elevated and genetic testing showed a previously unreported consensus splice-site mutation IVS4-1G>A in the HMBS gene confirming the diagnosis of Acute Intermittent Porphyria (AIP (show AIP ELISA Kits))

  2. The authors describe the biochemical characterisation of expressed HMBS mutants in a black South African population. This reveals insight into the mechanism of catalytic activity loss, which may inspire investigation into individualised therapy based on the molecular lesion identified.

  3. ALAS1 (show ALAS1 ELISA Kits) mRNA and activity were elevated approximately ~3- and 5-fold, and HMB synthase activity was approximately half-normal (~42%)

  4. in the hepatic cancer tissue of two acute porphyria patients, somatic second-hit mutations result in nearly complete inactivation of PPOX (show OX ELISA Kits) and HMBS

  5. study of hydroxymethylbilane synthase mutations and polymorphisms in Brazilian families with acute intermittent porphyria

  6. Letter/Case Report: R173W mutation of HMBS gene can cause rhabdomyolysis in patients with variant acute intermittent porphyria.

  7. we report a novel PBGD missense mutation.

  8. Novel porphobilinogen deaminase gene mutations have been described in Polish patients with non-erythroid acute intermittent porphyria.

  9. Conformational stability and activity of hydroxymethylbilane synthase (HMSB) and the acute intermittent porphyria K132N and V215E HMSB mutations.

  10. Dense geographic aggregation with one identical haplotype strongly suggests a remote founder phenomenon for these Venezuelan acute intermittent porphyria families, carrying an unreported but most frequent HMBS mutation.

Mouse (Murine) Hydroxymethylbilane Synthase (HMBS) interaction partners

  1. PBGD-deficient mice showed a different response to fasting as measured by altered carbohydrate metabolism in the liver and modified glucose consumption in the brain cortex. Glucose homeostasis in fasted PBGD-deficient mice was efficiently normalized after restoration of PBGD gene expression in the liver.

  2. Porphobilinogen deaminase over-expression in hepatocytes, albeit in a low proportion, reduced precursor accumulation, which is the hallmark of acute porphyric attacks.

  3. PBGD-deficient mice were characterized biochemically during phenobarbital induction of heme synthesis and enzyme replacement.

Arabidopsis thaliana Hydroxymethylbilane Synthase (HMBS) interaction partners

  1. The interactions observed between the two pyrrole rings of the HEMC dipyrromethane cofactor and the active-site residues are highly specific and are most likely to represent the catalytically relevant binding mode.

  2. Porphobilinogen deaminase deficiency alters vegetative and reproductive development and causes lesions in Arabidopsis.

  3. Crystallization and preliminary X-ray characterization of the tetrapyrrole-biosynthetic enzyme porphobilinogen deaminase from Arabidopsis thaliana. [porphobilinogen deaminase]

Hydroxymethylbilane Synthase (HMBS) Antigen Profile

Antigen Summary

This gene encodes a member of the hydroxymethylbilane synthase superfamily. The encoded protein is the third enzyme of the heme biosynthetic pathway and catalyzes the head to tail condensation of four porphobilinogen molecules into the linear hydroxymethylbilane. Mutations in this gene are associated with the autosomal dominant disease acute intermittent porphyria. Alternatively spliced transcript variants encoding different isoforms have been described.

Gene names and symbols associated with HMBS

  • hydroxymethylbilane synthase (HMBS) antibody
  • hydroxymethylbilane synthase (Hmbs) antibody
  • hydroxymethylbilane synthase (hmbs) antibody
  • hydroxymethylbilane synthase S homeolog (hmbs.2.S) antibody
  • hydroxymethylbilane synthase L homeolog (hmbs.L) antibody
  • hydroxymethylbilane synthase (CNC02250) antibody
  • hydroxymethylbilane synthase (predicted) (hem3) antibody
  • hydroxymethylbilane synthase (hemC) antibody
  • Hydroxymethylbilane synthase (Trad_0335) antibody
  • hydroxymethylbilane synthase (Plabr_2100) antibody
  • hydroxymethylbilane synthase (Sgly_3113) antibody
  • hydroxymethylbilane synthase (HEMC) antibody
  • porphobilinogen deaminase (hemC) antibody
  • hemC (hemC) antibody
  • porphobilinogen deaminase (Franean1_6130) antibody
  • porphobilinogen deaminase (PBGD1) antibody
  • hydroxymethylbilane synthase (SMLT_RS19660) antibody
  • hydroxymethylbilane synthase (PMI_RS16580) antibody
  • Porphobilinogen deaminase (hemC) antibody
  • porphobilinogen deaminase (Arnit_2733) antibody
  • porphobilinogen deaminase (Ndas_4371) antibody
  • hydroxymethylbilane synthase a (hmbsa) antibody
  • CMS2841 antibody
  • DDBDRAFT_0186148 antibody
  • DDBDRAFT_0231417 antibody
  • DDB_0186148 antibody
  • DDB_0231417 antibody
  • F8L15.10 antibody
  • F8L15_10 antibody
  • hemC antibody
  • hmbs antibody
  • hydroxymethylbilane synthase antibody
  • NV50236 antibody
  • pbg-d antibody
  • pbgd antibody
  • popE antibody
  • PORC antibody
  • SPAC806.01 antibody
  • T25658 antibody
  • Ups antibody
  • URO-S antibody
  • Uros1 antibody
  • zgc:64128 antibody

Protein level used designations for HMBS

porphobilinogen deaminase , porphyria, acute; Chester type , pre-uroporphyrinogen synthase , uroporphyrinogen I synthase , uroporphyrinogen I synthetase , alternative name: porphobilinogen deaminase , hydroxymethylbilane synthase , Hydroxymethylbilane synthase , PBG-D , porphobilinogen deaminase-like , Porphobilinogen deaminase

3145 Homo sapiens
25709 Rattus norvegicus
419701 Gallus gallus
448096 Xenopus (Silurana) tropicalis
495094 Xenopus laevis
515614 Bos taurus
702943 Macaca mulatta
734761 Xenopus laevis
3256245 Cryptococcus neoformans var. neoformans JEC21
3361383 Schizosaccharomyces pombe 972h-
8250098 Micromonas sp. RCC299
8624733 Dictyostelium discoideum AX4
9279308 Truepera radiovictrix DSM 17093
9350137 Helicobacter pylori B8
100121374 Nasonia vitripennis
15288 Mus musculus
10239509 Planctomyces brasiliensis DSM 5305
10250332 Syntrophobotulus glycolicus DSM 8271
100446876 Pongo abelii
830724 Arabidopsis thaliana
887306 Mycobacterium tuberculosis H37Rv
904871 Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819
1064946 Tropheryma whipplei TW08/27
1176684 Yersinia pestis CO92
1794978 Rhodopirellula baltica SH 1
2650205 Corynebacterium diphtheriae NCTC 13129
2662220 Bordetella bronchiseptica RB50
2860702 Staphylococcus aureus subsp. aureus MRSA252
2863981 Staphylococcus aureus subsp. aureus MSSA476
2885596 Pectobacterium atrosepticum SCRI1043
3233359 Ehrlichia ruminantium str. Welgevonden
4714897 Yersinia enterocolitica subsp. enterocolitica 8081
5175406 Clavibacter michiganensis subsp. michiganensis NCPPB 382
5185175 Clostridium botulinum A str. ATCC 3502
5674451 Frankia sp. EAN1pec
5727029 Chlamydomonas reinhardtii
6158370 Clavibacter michiganensis subsp. sepedonicus
6395026 Stenotrophomonas maltophilia K279a
6801447 Proteus mirabilis HI4320
6932678 Burkholderia cenocepacia J2315
6988643 Aliivibrio salmonicida LFI1238
7707286 Gemmatimonas aurantiaca T-27
8951204 Erwinia amylovora ATCC 49946
8995997 Salinibacter ruber M8
9172929 Arcobacter nitrofigilis DSM 7299
9248246 Nocardiopsis dassonvillei subsp. dassonvillei DSM 43111
394129 Danio rerio
489373 Canis lupus familiaris
396581 Sus scrofa
100720802 Cavia porcellus
Selected quality suppliers for Hydroxymethylbilane Synthase (HMBS) ELISA Kits
Did you look for something else?