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HMBS Products

(Hydroxymethylbilane Synthase (HMBS))

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This gene encodes a member of the hydroxymethylbilane synthase superfamily. The encoded protein is the third enzyme of the heme biosynthetic pathway and catalyzes the head to tail condensation of four porphobilinogen molecules into the linear hydroxymethylbilane. Mutations in this gene are associated with the autosomal dominant disease acute intermittent porphyria. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008].

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Featured HMBS Categories

HMBS Antibodies

High quality antibodies with extensive validation data.

HMBS ELISA Kits

Reliable ELISA kits for a wide range of species.

HMBS Proteins

Proteins for various applications incl. WB, ELISA, IF etc.

Recommended HMBS Antibodies

Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Application WB, ELISA, IHC, IF
Validations
  • (4)
Cat. No. ABIN7163904
Quantity 100 μg
Datasheet Datasheet
Reactivity Human
Application WB, IF
Validations
  • (1)
  • (2)
Cat. No. ABIN516532
Quantity 100 μg
Datasheet Datasheet
Reactivity Human
Application WB, ELISA
Validations
  • (3)
Cat. No. ABIN516533
Quantity 100 μg
Datasheet Datasheet

Recommended HMBS ELISA Kits

Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Analytical Method Quantitative Sandwich ELISA
Validations
  • (1)
Cat. No. ABIN6956629
Quantity 96 tests
Datasheet Datasheet
Reactivity Human
Analytical Method Quantitative Sandwich ELISA
Validations
Cat. No. ABIN5592154
Quantity 96 tests
Datasheet Datasheet
Reactivity Mouse
Analytical Method Quantitative Sandwich ELISA
Validations
Cat. No. ABIN6204971
Quantity 96 tests
Datasheet Datasheet

Recommended HMBS Proteins

Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Source Escherichia coli (E. coli)
Validations
  • (1)
Cat. No. ABIN7123381
Quantity 50 μg
Datasheet Datasheet
Reactivity Human
Source Wheat germ
Validations
  • (1)
Cat. No. ABIN1306784
Quantity 10 μg
Datasheet Datasheet
Reactivity Human
Source Human Cells
Validations
Cat. No. ABIN4370798
Quantity 50 μg
Datasheet Datasheet

Latest Publications for our HMBS products

Jiang, Berraondo, Jericó, Guey, Sampedro, Frassetto, Benenato, Burke, Santamaría, Alegre, Pejenaute, Kalariya, Butcher, Park, Zhu, Sabnis, Kumarasinghe, Salerno, Kenney, Lukacs, Ávila, Martini et al.: "Systemic messenger RNA as an etiological treatment for acute intermittent porphyria. ..." in: Nature medicine, Vol. 24, Issue 12, pp. 1899-1909, (2018) (PubMed).

Anand, Wilson, Hasan, Maytin: "Vitamin D3 enhances the apoptotic response of epithelial tumors to aminolevulinate-based photodynamic therapy." in: Cancer research, Vol. 71, Issue 18, pp. 6040-50, (2011) (PubMed).

Kuo, Lee, Chuang, Huang: "Acute intermittent porphyria with peripheral neuropathy: a follow-up study after hematin treatment." in: Journal of the neurological sciences, Vol. 260, Issue 1-2, pp. 231-5, (2007) (PubMed).

Synonyms and alternative names related to HMBS

hydroxymethylbilane synthase (HMBS), hydroxymethylbilane synthase (Hmbs), hydroxymethylbilane synthase (hmbs), hydroxymethylbilane synthase S homeolog (hmbs.2.S), hydroxymethylbilane synthase L homeolog (hmbs.L), hydroxymethylbilane synthase (CNC02250), hydroxymethylbilane synthase (predicted) (hem3), hydroxymethylbilane synthase (hemC), Hydroxymethylbilane synthase (Trad_0335), hydroxymethylbilane synthase (Plabr_2100), hydroxymethylbilane synthase (Sgly_3113), hydroxymethylbilane synthase (SMLT_RS19660), hydroxymethylbilane synthase (PMI_RS16580), hydroxymethylbilane synthase a (hmbsa), hydroxymethylbilane synthase, b (hmbsb), DDBDRAFT_0186148, DDBDRAFT_0231417, DDB_0186148, DDB_0231417, hemC, Hmbs, hmbs, hmbsl, id:ibd5004, im:7140060, NV50236, PBG-D, pbg-d, PBGD, pbgd, PORC, SPAC806.01, T25658, UPS, ups, Ups, URO-S, Uros1, zgc:64128, zgc:110690

Protein level used designations for HMBS

  • porphobilinogen deaminase
  • porphyria, acute; Chester type
  • pre-uroporphyrinogen synthase
  • uroporphyrinogen I synthase
  • uroporphyrinogen I synthetase
  • alternative name: porphobilinogen deaminase
  • hydroxymethylbilane synthase
  • Hydroxymethylbilane synthase
  • PBG-D
  • porphobilinogen deaminase-like
  • hydroxymethylbilane synthase, b
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